ID A0A1D7YGR6_9ACTN Unreviewed; 984 AA.
AC A0A1D7YGR6;
DT 18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT 18-JAN-2017, sequence version 1.
DT 24-JAN-2024, entry version 25.
DE RecName: Full=beta-galactosidase {ECO:0000256|ARBA:ARBA00012756};
DE EC=3.2.1.23 {ECO:0000256|ARBA:ARBA00012756};
GN ORFNames=BFF78_28950 {ECO:0000313|EMBL:AOR34539.1};
OS Streptomyces fodineus.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1904616 {ECO:0000313|EMBL:AOR34539.1, ECO:0000313|Proteomes:UP000094960};
RN [1] {ECO:0000313|Proteomes:UP000094960}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=TW1S1 {ECO:0000313|Proteomes:UP000094960};
RA Kim M.-K., Kim S.B.;
RT "Streptomyces puniciscabiei strain:TW1S1 Genome sequencing and assembly.";
RL Submitted (SEP-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Hydrolysis of terminal non-reducing beta-D-galactose residues
CC in beta-D-galactosides.; EC=3.2.1.23;
CC Evidence={ECO:0000256|ARBA:ARBA00001412};
CC -!- SIMILARITY: Belongs to the glycosyl hydrolase 35 family.
CC {ECO:0000256|ARBA:ARBA00009809, ECO:0000256|RuleBase:RU003679}.
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DR EMBL; CP017248; AOR34539.1; -; Genomic_DNA.
DR RefSeq; WP_069781088.1; NZ_CP017248.1.
DR AlphaFoldDB; A0A1D7YGR6; -.
DR KEGG; spun:BFF78_28950; -.
DR Proteomes; UP000094960; Chromosome.
DR GO; GO:0004565; F:beta-galactosidase activity; IEA:UniProtKB-EC.
DR GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR Gene3D; 2.102.20.10; Beta-galactosidase, domain 2; 1.
DR Gene3D; 2.60.390.10; Beta-galactosidase, domain 3; 1.
DR Gene3D; 2.60.120.260; Galactose-binding domain-like; 2.
DR Gene3D; 3.20.20.80; Glycosidases; 1.
DR InterPro; IPR018954; Betagal_dom2.
DR InterPro; IPR037110; Betagal_dom2_sf.
DR InterPro; IPR025972; BetaGal_dom3.
DR InterPro; IPR036833; BetaGal_dom3_sf.
DR InterPro; IPR025300; BetaGal_jelly_roll_dom.
DR InterPro; IPR008979; Galactose-bd-like_sf.
DR InterPro; IPR031330; Gly_Hdrlase_35_cat.
DR InterPro; IPR001944; Glycoside_Hdrlase_35.
DR InterPro; IPR017853; Glycoside_hydrolase_SF.
DR InterPro; IPR006311; TAT_signal.
DR PANTHER; PTHR23421:SF165; BETA-GALACTOSIDASE; 1.
DR PANTHER; PTHR23421; BETA-GALACTOSIDASE RELATED; 1.
DR Pfam; PF13364; BetaGal_ABD2; 2.
DR Pfam; PF10435; BetaGal_dom2; 1.
DR Pfam; PF13363; BetaGal_dom3; 1.
DR Pfam; PF01301; Glyco_hydro_35; 1.
DR PRINTS; PR00742; GLHYDRLASE35.
DR SMART; SM01029; BetaGal_dom2; 1.
DR SUPFAM; SSF51445; (Trans)glycosidases; 1.
DR SUPFAM; SSF117100; Beta-galactosidase LacA, domain 3; 1.
DR SUPFAM; SSF49785; Galactose-binding domain-like; 2.
DR SUPFAM; SSF51011; Glycosyl hydrolase domain; 1.
DR PROSITE; PS51318; TAT; 1.
PE 3: Inferred from homology;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Glycosidase {ECO:0000256|ARBA:ARBA00023295};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Signal {ECO:0000256|ARBA:ARBA00022729}.
FT DOMAIN 405..576
FT /note="Beta-galactosidase"
FT /evidence="ECO:0000259|SMART:SM01029"
FT REGION 30..54
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 670..694
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 672..686
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 984 AA; 106893 MW; 76C88A0F099FAB7E CRC64;
MALSRRNFSA LAGSTALGLA LGGSDGPGAP SAYAARSVPT GPAPAPPSAD GERHTIGYDR
YSLLVDGRRL VVWSGEMHPF RLPSPSLWRD VLQKMRAHGY NAVSIYVAWN YHSPAPGRYD
FTGVRDLGLF LRMAAETGLY VILRPGPYIN AEVDGGGFPG WLTATKGTAR TDDPTYLGHV
DEWLTQVNRI ARRHLFTQGT GTILLYQIEN EYDAHPGDAT GRAYMSHLYK KVRADGIDVP
LFHNDKGRNG YWVPGSFGTG GERGGWLYGF DGYPSPSQTP PDWGKFGPGG AHGGAGASPS
TPGFVPEFGG GWFDPWGGAW FDGKGYAESR RTTDAAYERR FYLTNLANGL TLHNVYMTFG
GTSWGWLPAP VVYTSYDYGA AIDEARNVTE KITPMHELGH LLQRVPDFAK LDRAADVHAE
GLKVYHLTNP DTGAHVYVTR NDGTQAVTAD LPTAEGRLRV TVPGKDAKLF TTGLSLGRRT
LKYANVQPVM CLNAGRQDIA VFAGRPGEMA ELVLKCPVEP DVMRLDPEAA WVVDNDELHV
NAPLGLGGLT RVLVQKGETG TPLLLLFADD GTAARLFPYD TPSGTLLVYG PALLRHVELR
GSEVHLTGDV TQTTSVEVWG PRGIDTLVWN GRTLPTRVTM SGSLMTTGPL PAAPEVKLPE
LGGWRMRTEN PEVGPSFDDS HWKTADKKTS FSTTPVPDGR PVLFADDYGF HYGDVWYRGT
FTDTTGLEEV ALAYSTGTQG LLMAWLDGEP LGTHRMPVPD RNTTVRQGTW ADTAVFPIRA
ALRSPGRHVL SVLVRRMQHD QDGKGLDTHK AARGLTAATF KGASPKVRWR IQGAAAPDPV
RGPMNNGGLY GEREGWHLPG FRDHDWEKAT FPRAARYQGV TWYRTTFRLS VPADVDASIG
LTLQDDPYRA YRAQIFLNGW NLGQYINGVG PQHTFVLPNG ILRTRGTNTL ALAVLSELTT
LSGPGKVGLT LLGRASGGLP VTPV
//
