ID A0A1D8AXK6_9BACT Unreviewed; 573 AA.
AC A0A1D8AXK6;
DT 18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT 18-JAN-2017, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE RecName: Full=inorganic diphosphatase {ECO:0000256|ARBA:ARBA00012146};
DE EC=3.6.1.1 {ECO:0000256|ARBA:ARBA00012146};
DE AltName: Full=Pyrophosphate phospho-hydrolase {ECO:0000256|ARBA:ARBA00032535};
GN ORFNames=Verru16b_02709 {ECO:0000313|EMBL:AOS45625.1};
OS Lacunisphaera limnophila.
OC Bacteria; Verrucomicrobiota; Opitutae; Opitutales; Opitutaceae;
OC Lacunisphaera.
OX NCBI_TaxID=1838286 {ECO:0000313|EMBL:AOS45625.1, ECO:0000313|Proteomes:UP000095228};
RN [1] {ECO:0000313|EMBL:AOS45625.1, ECO:0000313|Proteomes:UP000095228}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=IG16b {ECO:0000313|EMBL:AOS45625.1,
RC ECO:0000313|Proteomes:UP000095228};
RA Rast P., Gloeckner I., Jogler M., Boedeker C., Jeske O., Wiegand S.,
RA Reinhardt R., Schumann P., Rohde M., Spring S., Gloeckner F.O., Jogler C.;
RT "Three novel species with peptidoglycan cell walls form the new genus
RT Lacunisphaera gen. nov. in the family Opitutaceae of the verrucomicrobial
RT subdivision 4.";
RL Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=diphosphate + H2O = H(+) + 2 phosphate; Xref=Rhea:RHEA:24576,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:33019,
CC ChEBI:CHEBI:43474; EC=3.6.1.1;
CC Evidence={ECO:0000256|ARBA:ARBA00000926};
CC -!- COFACTOR:
CC Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC Evidence={ECO:0000256|ARBA:ARBA00001936};
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DR EMBL; CP016094; AOS45625.1; -; Genomic_DNA.
DR RefSeq; WP_069962752.1; NZ_CP016094.1.
DR AlphaFoldDB; A0A1D8AXK6; -.
DR STRING; 1838286.Verru16b_02709; -.
DR KEGG; obg:Verru16b_02709; -.
DR PATRIC; fig|1838286.3.peg.2723; -.
DR OrthoDB; 9766150at2; -.
DR Proteomes; UP000095228; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR GO; GO:0004427; F:inorganic diphosphate phosphatase activity; IEA:UniProtKB-EC.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR Gene3D; 3.10.580.10; CBS-domain; 1.
DR Gene3D; 3.10.310.20; DHHA2 domain; 1.
DR Gene3D; 3.40.1390.20; HprK N-terminal domain-like; 1.
DR Gene3D; 3.90.1640.10; inorganic pyrophosphatase (n-terminal core); 2.
DR InterPro; IPR000644; CBS_dom.
DR InterPro; IPR046342; CBS_dom_sf.
DR InterPro; IPR001667; DDH_dom.
DR InterPro; IPR038763; DHH_sf.
DR InterPro; IPR004097; DHHA2.
DR InterPro; IPR038222; DHHA2_dom_sf.
DR InterPro; IPR010766; DRTGG.
DR InterPro; IPR028979; Ser_kin/Pase_Hpr-like_N_sf.
DR PANTHER; PTHR12112; BNIP - RELATED; 1.
DR PANTHER; PTHR12112:SF22; MANGANESE-DEPENDENT INORGANIC PYROPHOSPHATASE; 1.
DR Pfam; PF00571; CBS; 2.
DR Pfam; PF01368; DHH; 1.
DR Pfam; PF02833; DHHA2; 1.
DR Pfam; PF07085; DRTGG; 1.
DR SMART; SM00116; CBS; 2.
DR SMART; SM01131; DHHA2; 1.
DR SUPFAM; SSF54631; CBS-domain pair; 1.
DR SUPFAM; SSF64182; DHH phosphoesterases; 1.
DR SUPFAM; SSF75138; HprK N-terminal domain-like; 1.
DR PROSITE; PS51371; CBS; 2.
PE 4: Predicted;
KW CBS domain {ECO:0000256|PROSITE-ProRule:PRU00703};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000313|EMBL:AOS45625.1};
KW Manganese {ECO:0000256|ARBA:ARBA00023211};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000095228}.
FT DOMAIN 76..132
FT /note="CBS"
FT /evidence="ECO:0000259|PROSITE:PS51371"
FT DOMAIN 260..317
FT /note="CBS"
FT /evidence="ECO:0000259|PROSITE:PS51371"
SQ SEQUENCE 573 AA; 62924 MW; 72A86B51FB0E2BB2 CRC64;
MVPAHPIYVI GHRNPDADSI CSAIAYAAFK EARGESGYVA ARCGNSNARI DAILERFHTP
LPLYLSDVSP RVRDLMTVNP YSVTLGATCA EALRMIDRHR LNVLPVVTAD NRATGTLTLA
QLGHFFIPRL DEPRAMRLVR TSLARIVESL QATVLNLVDG DRLEELFVRI GAMDISTFWS
ISEKDGIPAD QSIIIVGDRA DIQRRAIELG IRALIVSGNF PVDPAITSLA RERGVSILVS
AQDTATTGWF VRTASTIEQL TERNFASLNP DARITDIRKR FGQNAPHAMM VTSEDHTLLG
ILTKSDLLKP VPTRLVLVDH NELTQAVPGA DEVTITEILD HHRLGPMTTP QPILFVNEPV
GSTCTIVADQ FRRHGLTPTA DLAGIMMSGL ISDTLLLQSP TSTSKDADVL NWLQAHAGIK
AEELARLIFS SGSVILGNPA DKVVRSDFKV YEEEEVRFAV SQVEELGFDN FWQHAKPLAV
ALAELRATER LAFAVLLITD INTQNSLMLV KGDADFIHRI SYSQVEQDEV FDLPGVVSRK
KQLIPYLTDL LKAMHSEGVV PSNRGLTGSP FIR
//
