ID A0A1D8G0P1_9ACTN Unreviewed; 424 AA.
AC A0A1D8G0P1;
DT 18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT 18-JAN-2017, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE RecName: Full=L-lysine N6-monooxygenase MbtG {ECO:0000256|ARBA:ARBA00016406};
DE EC=1.14.13.59 {ECO:0000256|ARBA:ARBA00013076};
DE AltName: Full=Lysine 6-N-hydroxylase {ECO:0000256|ARBA:ARBA00032738};
DE AltName: Full=Lysine N6-hydroxylase {ECO:0000256|ARBA:ARBA00032493};
DE AltName: Full=Lysine-N-oxygenase {ECO:0000256|ARBA:ARBA00029939};
DE AltName: Full=Mycobactin synthase protein G {ECO:0000256|ARBA:ARBA00031158};
GN Name=iucD_1 {ECO:0000313|EMBL:AOT59010.1};
GN ORFNames=A4G23_01835 {ECO:0000313|EMBL:AOT59010.1};
OS Streptomyces rubrolavendulae.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=285473 {ECO:0000313|EMBL:AOT59010.1, ECO:0000313|Proteomes:UP000095349};
RN [1] {ECO:0000313|EMBL:AOT59010.1, ECO:0000313|Proteomes:UP000095349}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MJM4426 {ECO:0000313|EMBL:AOT59010.1,
RC ECO:0000313|Proteomes:UP000095349};
RA Kim J.-G.;
RT "Streptomyces rubrolavendulae MJM4426 Genome sequencing and assembly.";
RL Submitted (SEP-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=L-lysine + NADPH + O2 = H2O + N(6)-hydroxy-L-lysine + NADP(+);
CC Xref=Rhea:RHEA:23228, ChEBI:CHEBI:15377, ChEBI:CHEBI:15379,
CC ChEBI:CHEBI:32551, ChEBI:CHEBI:57783, ChEBI:CHEBI:57820,
CC ChEBI:CHEBI:58349; EC=1.14.13.59;
CC Evidence={ECO:0000256|ARBA:ARBA00000168};
CC -!- COFACTOR:
CC Name=FAD; Xref=ChEBI:CHEBI:57692;
CC Evidence={ECO:0000256|ARBA:ARBA00001974};
CC -!- PATHWAY: Siderophore biosynthesis. {ECO:0000256|ARBA:ARBA00004924}.
CC -!- SIMILARITY: Belongs to the lysine N(6)-hydroxylase/L-ornithine N(5)-
CC oxygenase family. {ECO:0000256|ARBA:ARBA00007588}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CP017316; AOT59010.1; -; Genomic_DNA.
DR RefSeq; WP_069976496.1; NZ_CP017316.1.
DR AlphaFoldDB; A0A1D8G0P1; -.
DR STRING; 285473.A4G23_01835; -.
DR KEGG; srn:A4G23_01835; -.
DR PATRIC; fig|285473.5.peg.1911; -.
DR OrthoDB; 7527071at2; -.
DR Proteomes; UP000095349; Chromosome.
DR GO; GO:0047091; F:L-lysine 6-monooxygenase (NADPH) activity; IEA:UniProtKB-EC.
DR GO; GO:0044249; P:cellular biosynthetic process; IEA:UniProt.
DR GO; GO:1901566; P:organonitrogen compound biosynthetic process; IEA:UniProt.
DR Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 1.
DR InterPro; IPR036188; FAD/NAD-bd_sf.
DR InterPro; IPR025700; Lys/Orn_oxygenase.
DR PANTHER; PTHR42802:SF1; L-ORNITHINE N(5)-MONOOXYGENASE; 1.
DR PANTHER; PTHR42802; MONOOXYGENASE; 1.
DR Pfam; PF13434; Lys_Orn_oxgnase; 1.
DR SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 1.
PE 3: Inferred from homology;
KW Monooxygenase {ECO:0000313|EMBL:AOT59010.1};
KW Oxidoreductase {ECO:0000313|EMBL:AOT59010.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000095349}.
SQ SEQUENCE 424 AA; 48027 MW; 2E52B6B70FD95AB9 CRC64;
MSTPLDLIGI GLGPFNLGLA CLTEPIEELD GLFLESKPDF EWHSGMFLEG AHLQTPFMSD
LVTLADPTSP YSFLNYLKEK GRLYSFYIRE NFYPLRAEYN DYCRWAAAKL GNVRFSTTVT
RVEYDEAEGV YAVHTDGGET YRARHLVLGT GTPPYVPEPC RDLGGDVLHN SRYMTSRDAL
KAKKSITVVG SGQSAAEIYF DLLSEIDVHG YRLNWVTRSP RFFPLEYTKL TLEMTSPEYV
DYFHALPEET RYRLETAQKG LFKGINGDLI DAIFDLLYQK SVETGGPVPT RLLTNSALES
ASYDEETGTY TLGLRQEEQG REFELHTEGL VLATGYKYRV PEFLEPVRDR LKWDGHGRFD
IARNYSVDVT GRGVFLQNAG VHAHSVTSPD LGMGPYRNSY IIRELLGTEY YPVEKSIAFQ
EFTV
//
