ID A0A1D8GG09_9CLOT Unreviewed; 289 AA.
AC A0A1D8GG09;
DT 18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT 18-JAN-2017, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE RecName: Full=High-affinity heme uptake system protein IsdE {ECO:0000256|ARBA:ARBA00015862};
DE AltName: Full=Iron-regulated surface determinant protein E {ECO:0000256|ARBA:ARBA00031463};
DE AltName: Full=Staphylococcal iron-regulated protein F {ECO:0000256|ARBA:ARBA00031148};
GN ORFNames=Gferi_09815 {ECO:0000313|EMBL:AOT69847.1};
OS Geosporobacter ferrireducens.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Clostridiaceae;
OC Geosporobacter.
OX NCBI_TaxID=1424294 {ECO:0000313|EMBL:AOT69847.1, ECO:0000313|Proteomes:UP000095743};
RN [1] {ECO:0000313|EMBL:AOT69847.1, ECO:0000313|Proteomes:UP000095743}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=IRF9 {ECO:0000313|EMBL:AOT69847.1,
RC ECO:0000313|Proteomes:UP000095743};
RA Kim S.-J.;
RT "Genomic analysis reveals versatility of anaerobic energy metabolism of
RT Geosporobacter ferrireducens IRF9 of phylum Firmicutes.";
RL Submitted (SEP-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=heme b; Xref=ChEBI:CHEBI:60344;
CC Evidence={ECO:0000256|ARBA:ARBA00001970};
CC -!- SIMILARITY: Belongs to the bacterial solute-binding protein 8 family.
CC {ECO:0000256|ARBA:ARBA00008814}.
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DR EMBL; CP017269; AOT69847.1; -; Genomic_DNA.
DR RefSeq; WP_069975956.1; NZ_CP017269.1.
DR AlphaFoldDB; A0A1D8GG09; -.
DR STRING; 1424294.Gferi_09815; -.
DR KEGG; gfe:Gferi_09815; -.
DR OrthoDB; 66025at2; -.
DR Proteomes; UP000095743; Chromosome.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0020037; F:heme binding; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0015886; P:heme transport; IEA:InterPro.
DR Gene3D; 3.40.50.1980; Nitrogenase molybdenum iron protein domain; 2.
DR InterPro; IPR019957; ABC_transptr_haem-bd_IsdE.
DR InterPro; IPR002491; ABC_transptr_periplasmic_BD.
DR NCBIfam; TIGR03659; IsdE; 1.
DR PANTHER; PTHR30535:SF36; HIGH-AFFINITY HEME UPTAKE SYSTEM PROTEIN ISDE; 1.
DR PANTHER; PTHR30535; VITAMIN B12-BINDING PROTEIN; 1.
DR Pfam; PF01497; Peripla_BP_2; 1.
DR SUPFAM; SSF53807; Helical backbone' metal receptor; 1.
DR PROSITE; PS50983; FE_B12_PBP; 1.
DR PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Heme {ECO:0000256|ARBA:ARBA00022617}; Iron {ECO:0000256|ARBA:ARBA00023004};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000095743};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..21
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 22..289
FT /note="High-affinity heme uptake system protein IsdE"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5038397706"
FT DOMAIN 35..289
FT /note="Fe/B12 periplasmic-binding"
FT /evidence="ECO:0000259|PROSITE:PS50983"
SQ SEQUENCE 289 AA; 32455 MW; 85BB2DFC8F5A0C9B CRC64;
MRKLITGLLC MSMILVSTGC AVRSSSENEN DPGIRIISTS AALCVILEKL DLDLVGVPET
AFQLPERYKD VTKVGLPMTP DLEIVKALNP TDVLTPNSLQ YDLKPQYESI GVPSTFVNLM
SLEGMFKSIE GLGKKYNRVP QAAALIEEYN RFMEDYHKKI EGKEKPRVLI LMGLPGTYMV
ATEKSYVGSL VRLAGGVNVF DSEEALLSVN TEALLQKDPD IILRTAHAMP EIVMESFEKE
FKENDIWKHF RAVQEGKVYN LSHEMFGMSA NLNYTEGLNY LQEILYEQE
//
