ID A0A1D8P8R2_9FLAO Unreviewed; 868 AA.
AC A0A1D8P8R2;
DT 18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT 18-JAN-2017, sequence version 1.
DT 24-JAN-2024, entry version 32.
DE RecName: Full=DNA mismatch repair protein MutS {ECO:0000256|HAMAP-Rule:MF_00096};
GN Name=mutS {ECO:0000256|HAMAP-Rule:MF_00096};
GN ORFNames=LPB138_09815 {ECO:0000313|EMBL:AOW20951.1};
OS Urechidicola croceus.
OC Bacteria; Bacteroidota; Flavobacteriia; Flavobacteriales;
OC Flavobacteriaceae; Urechidicola.
OX NCBI_TaxID=1850246 {ECO:0000313|EMBL:AOW20951.1, ECO:0000313|Proteomes:UP000176050};
RN [1] {ECO:0000313|EMBL:AOW20951.1, ECO:0000313|Proteomes:UP000176050}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=LPB0138 {ECO:0000313|EMBL:AOW20951.1,
RC ECO:0000313|Proteomes:UP000176050};
RA Kim E., Yi H.;
RT "Lutibacter sp. LPB0138, isolated from marine gastropod.";
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC It is possible that it carries out the mismatch recognition step. This
CC protein has a weak ATPase activity. {ECO:0000256|HAMAP-Rule:MF_00096}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC {ECO:0000256|ARBA:ARBA00006271, ECO:0000256|HAMAP-Rule:MF_00096,
CC ECO:0000256|RuleBase:RU003756}.
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DR EMBL; CP017478; AOW20951.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1D8P8R2; -.
DR STRING; 1850246.LPB138_09815; -.
DR KEGG; lul:LPB138_09815; -.
DR OrthoDB; 9802448at2; -.
DR Proteomes; UP000176050; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR CDD; cd03284; ABC_MutS1; 1.
DR Gene3D; 1.10.1420.10; -; 2.
DR Gene3D; 3.40.1170.10; DNA repair protein MutS, domain I; 1.
DR Gene3D; 3.30.420.110; MutS, connector domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR HAMAP; MF_00096; MutS; 1.
DR InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR InterPro; IPR036678; MutS_con_dom_sf.
DR InterPro; IPR045076; MutS_family.
DR InterPro; IPR027417; P-loop_NTPase.
DR NCBIfam; TIGR01070; mutS1; 1.
DR PANTHER; PTHR11361:SF34; DNA MISMATCH REPAIR PROTEIN MSH1, MITOCHONDRIAL; 1.
DR PANTHER; PTHR11361; DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER; 1.
DR Pfam; PF01624; MutS_I; 1.
DR Pfam; PF05188; MutS_II; 1.
DR Pfam; PF05192; MutS_III; 1.
DR Pfam; PF05190; MutS_IV; 1.
DR Pfam; PF00488; MutS_V; 1.
DR PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR SMART; SM00534; MUTSac; 1.
DR SMART; SM00533; MUTSd; 1.
DR SUPFAM; SSF55271; DNA repair protein MutS, domain I; 1.
DR SUPFAM; SSF53150; DNA repair protein MutS, domain II; 1.
DR SUPFAM; SSF48334; DNA repair protein MutS, domain III; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|HAMAP-
KW Rule:MF_00096}; Coiled coil {ECO:0000256|SAM:Coils};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|HAMAP-
KW Rule:MF_00096}; Reference proteome {ECO:0000313|Proteomes:UP000176050}.
FT DOMAIN 691..707
FT /note="DNA mismatch repair proteins mutS family"
FT /evidence="ECO:0000259|PROSITE:PS00486"
FT COILED 790..819
FT /evidence="ECO:0000256|SAM:Coils"
FT BINDING 617..624
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00096"
SQ SEQUENCE 868 AA; 97890 MW; F27D5D423EA04144 CRC64;
MAKAKKVTPL MKQYNSIKAK YPDAMLLFRV GDFYETFGDD AVKAAKILGI VLTKRGAGSE
TETALAGFPH HSMNTYLPKL VKAGCRVAIC DQLEDPKMTK TIVKRGVTEL VTPGVALNDE
VLQAKTNNFL AAIHFGKKLI GISFLDVSTG EYLAAQGNGE YIDKLLQNFN PSEVLVQKQY
KGKFLEVFGD RFNRFYLDDW VFQSDYANES LTNHFKIKSL KGFGIDELSE GIIAAGAVLY
YLSETQHNKL EHITSINRIA EDNYVWMDRF TIRNLELYYA NSPEAVTLLD VIDKTISPMG
GRLLKRWLAL PLKNAEQIKK RHEIVKYLID NDNFFETATY QINQISDIER LISKVATGKI
SPKEVVLLKD SLKAILPIKS SAEESDNSFL QHIGNELDDC KVLIEKITQT VNENAPVNIN
KGNAIAEGVS QELDDLRAIS TSGKEYLDNM LARETERTGI SSLKIAFNNV FGYYIEVRNT
HKDKVPEEWI RKQTLVSAER YITEELKEYE TKILGAEEKI GQLESQIFND LVTFLIKFIK
PVQKNAQLIA QIDCLCSFAK TAKDYNYVRP IIDESTDLEI KNGRHPVIEK QLPIGEEYIA
NDVVLNRNQQ QIIMITGPNM SGKSAILRQT ALIVLLAQMG SYVPAQNAKI GVIDKIFTRV
GASDNISMGE STFMVEMNET ASILNNLSER SLILLDEIGR GTSTYDGISI AWAIAEYIHE
HPTKAKTLFA THYHELNDMT ETFERVKNFN VSVKELKDNV IFLRKLVAGG SEHSFGIHVA
KLAGMPSTVI HRANKMLKKL EQSHSSEEIK DKLKQAQEEE DVQLSFFKLD DPLLENIKEE
ILTTNIDTLT PIEALMKLNE IKRMLTKK
//
