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Database: UniProt
Entry: A0A1D8PIH2_CANAL
LinkDB: A0A1D8PIH2_CANAL
Original site: A0A1D8PIH2_CANAL 
ID   A0A1D8PIH2_CANAL        Unreviewed;       514 AA.
AC   A0A1D8PIH2;
DT   18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT   18-JAN-2017, sequence version 1.
DT   16-JAN-2019, entry version 12.
DE   SubName: Full=Purine-cytosine permease {ECO:0000313|EMBL:AOW27973.1};
GN   Name=FCY21 {ECO:0000313|CGD:CAL0000195436,
GN   ECO:0000313|EMBL:AOW27973.1};
GN   OrderedLocusNames=orf19.1357 {ECO:0000313|CGD:CAL0000195436};
GN   ORFNames=CAALFM_C209950WA {ECO:0000313|EMBL:AOW27973.1};
OS   Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina;
OC   Saccharomycetes; Saccharomycetales; Debaryomycetaceae;
OC   Candida/Lodderomyces clade; Candida.
OX   NCBI_TaxID=237561 {ECO:0000313|EMBL:AOW27973.1, ECO:0000313|Proteomes:UP000000559};
RN   [1] {ECO:0000313|EMBL:AOW27973.1, ECO:0000313|Proteomes:UP000000559}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SC5314 / ATCC MYA-2876 {ECO:0000313|Proteomes:UP000000559};
RX   PubMed=15123810; DOI=10.1073/pnas.0401648101;
RA   Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S.,
RA   Magee B.B., Newport G., Thorstenson Y.R., Agabian N., Magee P.T.,
RA   Davis R.W., Scherer S.;
RT   "The diploid genome sequence of Candida albicans.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004).
RN   [2] {ECO:0000313|EMBL:AOW27973.1, ECO:0000313|Proteomes:UP000000559}
RP   GENOME REANNOTATION.
RC   STRAIN=SC5314 / ATCC MYA-2876 {ECO:0000313|Proteomes:UP000000559};
RX   PubMed=17419877; DOI=10.1186/gb-2007-8-4-r52;
RA   van het Hoog M., Rast T.J., Martchenko M., Grindle S., Dignard D.,
RA   Hogues H., Cuomo C., Berriman M., Scherer S., Magee B.B., Whiteway M.,
RA   Chibana H., Nantel A., Magee P.T.;
RT   "Assembly of the Candida albicans genome into sixteen supercontigs
RT   aligned on the eight chromosomes.";
RL   Genome Biol. 8:RESEARCH52.1-RESEARCH52.12(2007).
RN   [3] {ECO:0000313|EMBL:AOW27973.1, ECO:0000313|Proteomes:UP000000559}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SC5314 / ATCC MYA-2876 {ECO:0000313|Proteomes:UP000000559};
RX   PubMed=24025428; DOI=10.1186/gb-2013-14-9-r97;
RA   Muzzey D., Schwartz K., Weissman J.S., Sherlock G.;
RT   "Assembly of a phased diploid Candida albicans genome facilitates
RT   allele-specific measurements and provides a simple model for repeat
RT   and indel structure.";
RL   Genome Biol. 14:RESEARCH97.1-RESEARCH97.14(2013).
CC   -!- SIMILARITY: Belongs to the purine-cytosine permease (2.A.39)
CC       family. {ECO:0000256|PIRNR:PIRNR002744}.
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DR   EMBL; CP017624; AOW27973.1; -; Genomic_DNA.
DR   RefSeq; XP_714531.2; XM_709438.2.
DR   GeneID; 3643822; -.
DR   KEGG; cal:CAALFM_C209950WA; -.
DR   CGD; CAL0000195436; FCY21.
DR   OMA; ASWQIAF; -.
DR   OrthoDB; 488201at2759; -.
DR   Proteomes; UP000000559; Chromosome 2.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0015238; F:drug transmembrane transporter activity; IMP:CGD.
DR   GO; GO:0015205; F:nucleobase transmembrane transporter activity; IDA:CGD.
DR   GO; GO:0035690; P:cellular response to drug; IMP:CGD.
DR   GO; GO:0015856; P:cytosine transport; IDA:CGD.
DR   GO; GO:0015893; P:drug transport; IMP:CGD.
DR   GO; GO:0006863; P:purine nucleobase transport; IDA:CGD.
DR   Gene3D; 1.10.4160.10; -; 1.
DR   InterPro; IPR001248; Pur-cyt_permease.
DR   InterPro; IPR026030; Pur-cyt_permease_Fcy2/21/22.
DR   InterPro; IPR038271; Pur-cyt_permease_sf.
DR   PANTHER; PTHR31806; PTHR31806; 1.
DR   Pfam; PF02133; Transp_cyt_pur; 1.
DR   PIRSF; PIRSF002744; Pur-cyt_permease; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000000559};
KW   Membrane {ECO:0000256|PIRNR:PIRNR002744, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000559};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|PIRNR:PIRNR002744}.
FT   TRANSMEM     79    102       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    108    133       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    145    163       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    183    204       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    211    229       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    249    271       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    283    309       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    338    357       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    378    398       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    410    429       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    450    469       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    489    508       Helical. {ECO:0000256|SAM:Phobius}.
SQ   SEQUENCE   514 AA;  56496 MW;  D91957FD129269B0 CRC64;
     MSSDPEKNLG MPEKTSVNSY DSMDPSSSSS GADAEIETTK LNFIDRWAHK LNAETKGIEL
     VTDEEKTDTS FWNLATMWLS ANLVIATFSL GALGITVFGL AFGQAVLVII FFSILGGFPV
     AFFSCFGSAL GLRQMLLSKF LIGDLTTRLF AAINVVACVG WGAVNTMSSA QLLHIVNNGT
     LPPWAGCLII VVCTVLVTFF GYHVIHAYEK WAWIPNLIIF IIIIVRFAMT NKFTSKSFEG
     GETTAGNVLS FGGTVFGFAT GWTTYSSDYV VYHPRNTNSW KIFFSIFFGL LTPLMFTLIL
     GAACATGIAG DPEWTRLYKE DSVGGLVYAI LVHDSLHGFG QFCCVVLALS TVANNVPNMY
     SMALSAQTVW AGFRKIPRVA WTIAGNGATL AICIPAYYKF EAVMENFMNL ISYYLSIYES
     IMFASHFIWN SGRFDGYDYE RWNDKEAYPV GYAGVFGFAC GVAGVVLGMN QTWYSGVIGR
     RIGEFGGDIG FELAIGFAFI GFNVARYFEK KYIR
//
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