ID A0A1D8PT90_CANAL Unreviewed; 258 AA.
AC A0A1D8PT90;
DT 18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT 18-JAN-2017, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE RecName: Full=Bax inhibitor 1 {ECO:0008006|Google:ProtNLM};
GN Name=YBH3 {ECO:0000313|CGD:CAL0000175245};
GN OrderedLocusNames=CAALFM_CR06560CA {ECO:0000313|EMBL:AOW31355.1},
GN orf19.916 {ECO:0000313|CGD:CAL0000175245};
OS Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX NCBI_TaxID=237561 {ECO:0000313|EMBL:AOW31355.1, ECO:0000313|Proteomes:UP000000559};
RN [1] {ECO:0000313|EMBL:AOW31355.1, ECO:0000313|Proteomes:UP000000559}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SC5314 / ATCC MYA-2876 {ECO:0000313|Proteomes:UP000000559};
RX PubMed=15123810; DOI=10.1073/pnas.0401648101;
RA Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B.,
RA Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W.,
RA Scherer S.;
RT "The diploid genome sequence of Candida albicans.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004).
RN [2] {ECO:0000313|EMBL:AOW31355.1, ECO:0000313|Proteomes:UP000000559}
RP GENOME REANNOTATION.
RC STRAIN=SC5314 / ATCC MYA-2876 {ECO:0000313|Proteomes:UP000000559};
RX PubMed=17419877; DOI=.1186/gb-2007-8-4-r52;
RA van het Hoog M., Rast T.J., Martchenko M., Grindle S., Dignard D.,
RA Hogues H., Cuomo C., Berriman M., Scherer S., Magee B.B., Whiteway M.,
RA Chibana H., Nantel A., Magee P.T.;
RT "Assembly of the Candida albicans genome into sixteen supercontigs aligned
RT on the eight chromosomes.";
RL Genome Biol. 8:RESEARCH52.1-RESEARCH52.12(2007).
RN [3] {ECO:0000313|EMBL:AOW31355.1, ECO:0000313|Proteomes:UP000000559}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SC5314 / ATCC MYA-2876 {ECO:0000313|Proteomes:UP000000559};
RX PubMed=24025428; DOI=.1186/gb-2013-14-9-r97;
RA Muzzey D., Schwartz K., Weissman J.S., Sherlock G.;
RT "Assembly of a phased diploid Candida albicans genome facilitates allele-
RT specific measurements and provides a simple model for repeat and indel
RT structure.";
RL Genome Biol. 14:RESEARCH97.1-RESEARCH97.14(2013).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the BI1 family. {ECO:0000256|RuleBase:RU004379}.
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DR EMBL; CP017630; AOW31355.1; -; Genomic_DNA.
DR RefSeq; XP_710035.2; XM_704943.2.
DR AlphaFoldDB; A0A1D8PT90; -.
DR SMR; A0A1D8PT90; -.
DR STRING; 237561.A0A1D8PT90; -.
DR EnsemblFungi; CR_06560C_A-T; CR_06560C_A-T-p1; CR_06560C_A.
DR GeneID; 3648367; -.
DR KEGG; cal:CAALFM_CR06560CA; -.
DR CGD; CAL0000175245; YBH3.
DR VEuPathDB; FungiDB:CR_06560C_A; -.
DR eggNOG; KOG2322; Eukaryota.
DR InParanoid; A0A1D8PT90; -.
DR OrthoDB; 944911at2759; -.
DR Proteomes; UP000000559; Chromosome R.
DR GO; GO:0005783; C:endoplasmic reticulum; IEA:EnsemblFungi.
DR GO; GO:0000324; C:fungal-type vacuole; IEA:EnsemblFungi.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR GO; GO:0005739; C:mitochondrion; IEA:EnsemblFungi.
DR GO; GO:0006915; P:apoptotic process; IEA:EnsemblFungi.
DR GO; GO:0019722; P:calcium-mediated signaling; IEA:EnsemblFungi.
DR GO; GO:0030968; P:endoplasmic reticulum unfolded protein response; IEA:EnsemblFungi.
DR GO; GO:0060258; P:negative regulation of filamentous growth; IMP:CGD.
DR GO; GO:0043065; P:positive regulation of apoptotic process; IMP:CGD.
DR CDD; cd10429; GAAP_like; 1.
DR InterPro; IPR006214; Bax_inhibitor_1-related.
DR PANTHER; PTHR23291; BAX INHIBITOR-RELATED; 1.
DR PANTHER; PTHR23291:SF129; GROWTH HORMONE-INDUCIBLE TRANSMEMBRANE PROTEIN-RELATED; 1.
DR Pfam; PF01027; Bax1-I; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU004379};
KW Reference proteome {ECO:0000313|Proteomes:UP000000559};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU004379};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU004379}.
FT TRANSMEM 55..73
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU004379"
FT TRANSMEM 85..106
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU004379"
FT TRANSMEM 112..133
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU004379"
FT TRANSMEM 140..160
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU004379"
FT TRANSMEM 166..189
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU004379"
FT TRANSMEM 201..218
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU004379"
FT TRANSMEM 230..252
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU004379"
FT REGION 1..23
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..16
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 258 AA; 29170 MW; 3B755E0A3F00D4ED CRC64;
MSSYTELPQS APPYSEGESG SPPRQFGDNI PDDFKYSVSV ASCELPLRQL FIRKVYSLLT
IQLMGSVIMG FIIRSSDSFK IWAMTNTWLL ILSFIGSIGF MIGAFFKARS YPINLILLGG
FTICESYTLG VACAFIESGI LIEAILLTLI IFIGLTIFAF QTKYDFISWQ GTVGMMLWGL
IGWGFVMMFI PHQQNSMMEN VYSFLGALIF SIYIIIDTQH IMKTLHLDDE IIGCISLYLD
IINLFLFILR ILNNNRDD
//
