ID A0A1D8PTC8_CANAL Unreviewed; 1558 AA.
AC A0A1D8PTC8;
DT 18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT 18-JAN-2017, sequence version 1.
DT 27-MAR-2024, entry version 41.
DE SubName: Full=Ras family guanine nucleotide exchange factor {ECO:0000313|EMBL:AOW31386.1};
GN Name=BUD5 {ECO:0000313|CGD:CAL0000195920,
GN ECO:0000313|EMBL:AOW31386.1};
GN OrderedLocusNames=CAALFM_CR06910WA {ECO:0000313|EMBL:AOW31386.1},
GN orf19.9401 {ECO:0000313|CGD:CAL0000195920};
OS Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX NCBI_TaxID=237561 {ECO:0000313|EMBL:AOW31386.1, ECO:0000313|Proteomes:UP000000559};
RN [1] {ECO:0000313|EMBL:AOW31386.1, ECO:0000313|Proteomes:UP000000559}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SC5314 / ATCC MYA-2876 {ECO:0000313|Proteomes:UP000000559};
RX PubMed=15123810; DOI=10.1073/pnas.0401648101;
RA Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B.,
RA Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W.,
RA Scherer S.;
RT "The diploid genome sequence of Candida albicans.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004).
RN [2] {ECO:0000313|EMBL:AOW31386.1, ECO:0000313|Proteomes:UP000000559}
RP GENOME REANNOTATION.
RC STRAIN=SC5314 / ATCC MYA-2876 {ECO:0000313|Proteomes:UP000000559};
RX PubMed=17419877; DOI=.1186/gb-2007-8-4-r52;
RA van het Hoog M., Rast T.J., Martchenko M., Grindle S., Dignard D.,
RA Hogues H., Cuomo C., Berriman M., Scherer S., Magee B.B., Whiteway M.,
RA Chibana H., Nantel A., Magee P.T.;
RT "Assembly of the Candida albicans genome into sixteen supercontigs aligned
RT on the eight chromosomes.";
RL Genome Biol. 8:RESEARCH52.1-RESEARCH52.12(2007).
RN [3] {ECO:0000313|EMBL:AOW31386.1, ECO:0000313|Proteomes:UP000000559}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SC5314 / ATCC MYA-2876 {ECO:0000313|Proteomes:UP000000559};
RX PubMed=24025428; DOI=.1186/gb-2013-14-9-r97;
RA Muzzey D., Schwartz K., Weissman J.S., Sherlock G.;
RT "Assembly of a phased diploid Candida albicans genome facilitates allele-
RT specific measurements and provides a simple model for repeat and indel
RT structure.";
RL Genome Biol. 14:RESEARCH97.1-RESEARCH97.14(2013).
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DR EMBL; CP017630; AOW31386.1; -; Genomic_DNA.
DR RefSeq; XP_711071.2; XM_705979.2.
DR AlphaFoldDB; A0A1D8PTC8; -.
DR STRING; 237561.A0A1D8PTC8; -.
DR EnsemblFungi; CR_06910W_A-T; CR_06910W_A-T-p1; CR_06910W_A.
DR GeneID; 3647315; -.
DR KEGG; cal:CAALFM_CR06910WA; -.
DR CGD; CAL0000195920; BUD5.
DR VEuPathDB; FungiDB:CR_06910W_A; -.
DR eggNOG; KOG3417; Eukaryota.
DR InParanoid; A0A1D8PTC8; -.
DR OrthoDB; 68574at2759; -.
DR Proteomes; UP000000559; Chromosome R.
DR GO; GO:0001411; C:hyphal tip; IDA:CGD.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IBA:GO_Central.
DR GO; GO:0030447; P:filamentous growth; IEA:UniProt.
DR GO; GO:0007265; P:Ras protein signal transduction; IBA:GO_Central.
DR CDD; cd00155; RasGEF; 1.
DR CDD; cd06224; REM; 1.
DR Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 1.
DR InterPro; IPR008937; Ras-like_GEF.
DR InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR InterPro; IPR001895; RASGEF_cat_dom.
DR InterPro; IPR036964; RASGEF_cat_dom_sf.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR23113:SF354; BUD SITE SELECTION PROTEIN 5; 1.
DR PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR Pfam; PF00617; RasGEF; 1.
DR Pfam; PF00618; RasGEF_N; 1.
DR SMART; SM00147; RasGEF; 1.
DR SMART; SM00229; RasGEFN; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF48366; Ras GEF; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS50009; RASGEF_CAT; 1.
DR PROSITE; PS50212; RASGEF_NTER; 1.
DR PROSITE; PS50002; SH3; 1.
PE 4: Predicted;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW ECO:0000256|PROSITE-ProRule:PRU00168};
KW Reference proteome {ECO:0000313|Proteomes:UP000000559};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 460..528
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 994..1119
FT /note="N-terminal Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50212"
FT DOMAIN 1275..1520
FT /note="Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50009"
FT REGION 1..115
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 135..165
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 177..207
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 326..387
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 436..458
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 885..904
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 960..981
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1179..1205
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..32
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 55..95
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 143..165
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 177..192
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 326..342
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 343..357
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 358..384
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 886..904
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1558 AA; 176760 MW; 55E2E123CAE54457 CRC64;
MFQQPNYSDP GKHISTSSSV YPDSNSASPE SSPRIPGAFE QIIIPRHKEN PFRTNKPIEQ
QQQQQQQQQQ QQQQQQQQQQ QQQQQQQQQQ HQQHQEHQAN GHDEEQNRMP TEGSNQTFQS
YMTARSGAYS FEEEDYENEV AGHQDQQSEN GSIYSQNQEP QLRNAPSFSS INESIFHNSS
KNTTLDTTEN DETPLIDSSE RYPDETPIVD DNGFLHEINH GEKDIIASEP IDSNEPTSLL
PKQNLSKKFK RVSVALQNTR TSGESYNFRY VFQNNVDQAN RTATQDNTAP KLERKSTYYR
KLQEKKLQSS QEQQGTEVEN MVISNDQHSE ASSISTRASS THTDTSGRDD EQDDNLVKKN
STNSSSNFVF SNNNLPSSYN LGGSKVNDDI PIRKDLIREN KAQVQQDAID RERLQMYNNS
TAMSEEGGLN IVYKDANTTS DDTYSKPPSP TKSEEKEDNL SDFFIRALHS FDSSTLQSKS
DASICLSFEK NDIAFLHTID ESGWGEVTLL ETLQTGWIPM NYFSLVVTSS DDEEDEDDSY
EDNDDDDSNK IPNNHYLKPL LHACGQFLSN PLSHKDRRNK YTFSIRVINS IRDGVRLLLQ
QTDCLSRSNE LVTKRPIVRK SRKSLLADWY NLMVKANEFK GTSNYNKIEI LTLMVYQVSR
KAVSFLEIWS AESKEIITRD HTGKKLYDDL NDCPLLKTPP LAKQRITEIH GVLFSYLGLI
IGRLDLIEHN QIGCDMLETL AHQIILLLRE LLFVSRTGSE YSKDKPRELD SSLDGLLSLV
SDLVASVKNL VVRTVNETEE DRIHKFGGPQ LNGARDYYYT PEGGELLQIA SRMVKAISVT
VASIRKLLEV TGDFKLSSER SYPDYSKMRI EPQEFIKKCS QGITKPKDMP IQQPNGATST
SNSGGIKAYK ANRYSMIRAG KTGDLGLTEN GVNYLQSLNN ENGNGNNVVD ELDGSSPFTS
SAPEFKPFTS EGGNESNNDA NINANINNEL SVDSNGNLLG GSFKGLVYTL TNEDSPPEYF
FVSTFFICFR SFSTGIDLIE ELITRFQVGY VSNDINIDLK LKKRRKLVAK SIQLWMESYW
NHEADYNLLT TLINFFNEGM SDYLPLDAIR LIDIGARLSS RPLVENRSRR IKDTKQLVNR
SITNAAKLPR KTGSILGDEI NRYSMIDSYS LSKINSTSSS NSTTSSSGHS ASLPMPLGPT
STSKTSLLTS SQLETIEKVN LTYRAILGNS WCSQKYINSI KYIPLDLSVL MPNFYIICDQ
SWVLSNYRPN LLDFNGLEIA KQLTLLESYI FCSIKPDELL NQNYTTKRAH LKLAPNVRLS
LLFTNCLSGY VIESILQPNI TIKLRISMVK IWLKIAISCL YLRNFNSLAA IITALESHLI
TRISSIWIKL EDKYTELYDY LSSIIHPEKN YRVYRNKLRN FLNSPMGLET PPIPIVPYFS
LFLQDLTFIN DGNPNYRKAN TFLNQKLINI DKYLKITRII ADIECLQISY LDDPNIVGNG
DGNSLMENGD DKPNYTINPV APLQELILLE LWKICQLNKT EEDRAWKLSC KIQPRDVS
//