ID A0A1D8S295_9EURY Unreviewed; 303 AA.
AC A0A1D8S295; A0A1J1AAG7;
DT 18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT 18-JAN-2017, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=Peptidase S49 {ECO:0000313|EMBL:AOW79466.1};
GN ORFNames=HSR6_0251 {ECO:0000313|EMBL:APE94719.1}, HTSR_0264
GN {ECO:0000313|EMBL:AOW79466.1};
OS Halodesulfurarchaeum formicicum.
OC Archaea; Euryarchaeota; Stenosarchaea group; Halobacteria; Halobacteriales;
OC Halobacteriaceae; Halodesulfurarchaeum.
OX NCBI_TaxID=1873524 {ECO:0000313|EMBL:AOW79466.1, ECO:0000313|Proteomes:UP000185608};
RN [1] {ECO:0000313|EMBL:AOW79466.1, ECO:0000313|Proteomes:UP000185608}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=HTSR1 {ECO:0000313|EMBL:AOW79466.1,
RC ECO:0000313|Proteomes:UP000185608};
RA Sorokin D.Y., Kublanov I.V., Roman P., Sinninghe Damste J.S.,
RA Golyshin P.N., Rojo D., Ciordia S., Mena Md.C., Ferrer M., Smedile F.,
RA Messina E., La Cono V., Yakimov M.M.;
RT "Discovery of anaerobic lithoheterotrophic haloarchaeon capable of sulfur
RT respiration by hydrogen and formate.";
RL Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000186165}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=HSR6 {ECO:0000313|Proteomes:UP000186165};
RA Sorokin D.Y., Kublanov I.V., Roman P., Sinninghe Damste J.S.,
RA Golyshin P.N., Rojo D., Ciordia S., Mena Md.C., Ferrer M., Smedile F.,
RA Messina E., La Cono V., Yakimov M.M.;
RT "Discovery of first anaerobic lithoheterotrophic haloarchae widely
RT represented in hypersaline habitats.";
RL Submitted (AUG-2016) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:APE94719.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=HSR6 {ECO:0000313|EMBL:APE94719.1};
RX PubMed=28106880; DOI=10.1038/ismej.2016.203;
RA Sorokin D.Y., Messina E., Smedile F., Roman P., Damste J.S.S., Ciordia S.,
RA Mena M.C., Ferrer M., Golyshin P.N., Kublanov I.V., Samarov N.I.,
RA Toshchakov S.V., La Cono V., Yakimov M.M.;
RT "Discovery of anaerobic lithoheterotrophic haloarchaea, ubiquitous in
RT hypersaline habitats.";
RL ISME J. 11:1245-1260(2017).
CC -!- SIMILARITY: Belongs to the peptidase S49 family.
CC {ECO:0000256|ARBA:ARBA00008683}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CP016070; AOW79466.1; -; Genomic_DNA.
DR EMBL; CP016804; APE94719.1; -; Genomic_DNA.
DR RefSeq; WP_070364233.1; NZ_CP016804.1.
DR AlphaFoldDB; A0A1D8S295; -.
DR STRING; 1873524.HSR6_0251; -.
DR GeneID; 30416775; -.
DR KEGG; halh:HTSR_0264; -.
DR KEGG; hhsr:HSR6_0251; -.
DR PATRIC; fig|1855411.3.peg.260; -.
DR OrthoDB; 27099at2157; -.
DR Proteomes; UP000185608; Chromosome.
DR Proteomes; UP000186165; Chromosome.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0008236; F:serine-type peptidase activity; IEA:UniProtKB-KW.
DR GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR CDD; cd07023; S49_Sppa_N_C; 1.
DR InterPro; IPR029045; ClpP/crotonase-like_dom_sf.
DR InterPro; IPR002142; Peptidase_S49.
DR InterPro; IPR047272; S49_SppA_C.
DR PANTHER; PTHR42987; PEPTIDASE S49; 1.
DR PANTHER; PTHR42987:SF4; PROTEASE SLR0021-RELATED; 1.
DR Pfam; PF01343; Peptidase_S49; 2.
DR SUPFAM; SSF52096; ClpP/crotonase; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022670};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Protease {ECO:0000256|ARBA:ARBA00022670};
KW Reference proteome {ECO:0000313|Proteomes:UP000186165};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 12..31
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 101..149
FT /note="Peptidase S49"
FT /evidence="ECO:0000259|Pfam:PF01343"
FT DOMAIN 170..238
FT /note="Peptidase S49"
FT /evidence="ECO:0000259|Pfam:PF01343"
SQ SEQUENCE 303 AA; 31672 MW; F9DF22BFF66FEEB4 CRC64;
MSNRIDDFVR ELLSSYAVLA IIGILVGAIL IPPGLGAVAG ADGTVAVVTI DESITGATAD
TTAQELRDVR EDDSIDAVVL RVDSGGGAVT GSETQYRAVK RLAQEKPVVT SVRSMAASGA
YYTILPSDTI YAQPSSMVGH VGVIASYADS EGVPASMTSG PDKASGATID EYQAQLETLK
RSFVSTVMNE RGEEITLSRT EVAQAKIYTG AEAVENGYAD RIGGLETAIQ AAAEKADLGS
YETEHRDPVS ITDLLSLIGL ESGSTTPETL FHSPGVDRVR YLALWGTPAE IGTNSTEVTT
YAG
//
