ID A0A1D9GZI1_9BURK Unreviewed; 360 AA.
AC A0A1D9GZI1;
DT 15-FEB-2017, integrated into UniProtKB/TrEMBL.
DT 15-FEB-2017, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE RecName: Full=Lipopolysaccharide heptosyltransferase 1 {ECO:0000256|ARBA:ARBA00044190};
DE EC=2.4.99.23 {ECO:0000256|ARBA:ARBA00044041};
DE AltName: Full=ADP-heptose:lipopolysaccharide heptosyltransferase I {ECO:0000256|ARBA:ARBA00044330};
GN ORFNames=BKK79_15440 {ECO:0000313|EMBL:AOY93027.1};
OS Cupriavidus sp. USMAA2-4.
OC Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales;
OC Burkholderiaceae; Cupriavidus.
OX NCBI_TaxID=876364 {ECO:0000313|EMBL:AOY93027.1, ECO:0000313|Proteomes:UP000178101};
RN [1] {ECO:0000313|EMBL:AOY93027.1, ECO:0000313|Proteomes:UP000178101}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=USMAA2-4 {ECO:0000313|EMBL:AOY93027.1,
RC ECO:0000313|Proteomes:UP000178101};
RA Abdullah A.A.-A., Shafie N.A.H., Lau N.S.;
RT "Complete genome sequences of three Cupriavidus strains isolated from
RT various Malaysian environments.";
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ADP-L-glycero-beta-D-manno-heptose + an alpha-Kdo-(2->4)-
CC alpha-Kdo-(2->6)-lipid A = ADP + an L-alpha-D-Hep-(1->5)-[alpha-Kdo-
CC (2->4)]-alpha-Kdo-(2->6)-lipid A + H(+); Xref=Rhea:RHEA:74067,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:61506, ChEBI:CHEBI:176431,
CC ChEBI:CHEBI:193068, ChEBI:CHEBI:456216; EC=2.4.99.23;
CC Evidence={ECO:0000256|ARBA:ARBA00043802};
CC -!- PATHWAY: Bacterial outer membrane biogenesis; LPS core biosynthesis.
CC {ECO:0000256|ARBA:ARBA00004713}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane
CC {ECO:0000256|ARBA:ARBA00004515}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004515}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004515}. Membrane
CC {ECO:0000256|ARBA:ARBA00004287}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004287}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004287}.
CC -!- SIMILARITY: Belongs to the glycosyltransferase 9 family.
CC {ECO:0000256|ARBA:ARBA00043995}.
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DR EMBL; CP017748; AOY93027.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1D9GZI1; -.
DR STRING; 876364.BKK79_15440; -.
DR KEGG; cuu:BKK79_15440; -.
DR Proteomes; UP000178101; Chromosome 1.
DR GO; GO:0008920; F:lipopolysaccharide heptosyltransferase activity; IEA:InterPro.
DR GO; GO:0009244; P:lipopolysaccharide core region biosynthetic process; IEA:InterPro.
DR CDD; cd03789; GT9_LPS_heptosyltransferase; 1.
DR Gene3D; 3.40.50.2000; Glycogen Phosphorylase B; 2.
DR InterPro; IPR002201; Glyco_trans_9.
DR InterPro; IPR011908; LipoPS_heptosylTferase-I.
DR NCBIfam; TIGR02193; heptsyl_trn_I; 1.
DR PANTHER; PTHR30160:SF19; LIPOPOLYSACCHARIDE HEPTOSYLTRANSFERASE 1; 1.
DR PANTHER; PTHR30160; TETRAACYLDISACCHARIDE 4'-KINASE-RELATED; 1.
DR Pfam; PF01075; Glyco_transf_9; 1.
DR SUPFAM; SSF53756; UDP-Glycosyltransferase/glycogen phosphorylase; 1.
PE 3: Inferred from homology;
KW Cell inner membrane {ECO:0000256|ARBA:ARBA00022519};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Glycosyltransferase {ECO:0000256|ARBA:ARBA00022676};
KW Lipopolysaccharide biosynthesis {ECO:0000256|ARBA:ARBA00022985};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Reference proteome {ECO:0000313|Proteomes:UP000178101};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:AOY93027.1}.
SQ SEQUENCE 360 AA; 39674 MW; B52635EBAF72AD4E CRC64;
MRENSRSDMG HLPVPAADAV GGFPLPARPR ILIVKVSSLG DVVHNMPLVH DLRARWPGCE
IDWVVEEGYV DLVRLLPEVR RVIPFALRRW RKRFYQGGTW REVAALRAAL RESAYDAVIE
SQGLLKTAVV ARAARRRPGA PVIGLANATQ GSGYEPAARL FYTLDVRVPR QTHSVRRSRL
LGAALTGMAP PEPPRFFGPQ ARSLHVDDPH WAGLPARYAV CFHATAGARK RWPLASWHAL
GQRLRAEGLA VLLPWGNEAE RRVAEEIAAG VPQAQVLPRF SVMQGFGLIN RAEVVVGVDT
GLVHIAAALC RPTVEIYTAT WRWKTEGYWS DAVANVGDDG VVPTVDEVYE AARHVRGMTA
//
