ID A0A1D9P5Q3_9FIRM Unreviewed; 552 AA.
AC A0A1D9P5Q3;
DT 15-FEB-2017, integrated into UniProtKB/TrEMBL.
DT 15-FEB-2017, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE RecName: Full=DNA polymerase III subunit gamma/tau {ECO:0000256|RuleBase:RU364063};
DE EC=2.7.7.7 {ECO:0000256|RuleBase:RU364063};
GN Name=dnaX {ECO:0000256|RuleBase:RU364063};
GN ORFNames=bhn_II070 {ECO:0000313|EMBL:AOZ97869.1};
OS Butyrivibrio hungatei.
OG Plasmid pnp144 {ECO:0000313|Proteomes:UP000179284}.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Lachnospiraceae;
OC Butyrivibrio.
OX NCBI_TaxID=185008 {ECO:0000313|EMBL:AOZ97869.1, ECO:0000313|Proteomes:UP000179284};
RN [1] {ECO:0000313|Proteomes:UP000179284}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MB2003 {ECO:0000313|Proteomes:UP000179284};
RC PLASMID=Plasmid pnp144 {ECO:0000313|Proteomes:UP000179284};
RA Palevich N., Kelly W.J., Leahy S.C., Altermann E., Rakonjac J.,
RA Attwood G.T.;
RT "The complete genome sequence of the rumen bacterium Butyrivibrio hungatei
RT MB2003.";
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: DNA polymerase III is a complex, multichain enzyme
CC responsible for most of the replicative synthesis in bacteria. This DNA
CC polymerase also exhibits 3' to 5' exonuclease activity.
CC {ECO:0000256|RuleBase:RU364063}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC ChEBI:CHEBI:173112; EC=2.7.7.7;
CC Evidence={ECO:0000256|ARBA:ARBA00024632,
CC ECO:0000256|RuleBase:RU364063};
CC -!- SUBUNIT: DNA polymerase III contains a core (composed of alpha, epsilon
CC and theta chains) that associates with a tau subunit. This core
CC dimerizes to form the POLIII' complex. PolIII' associates with the
CC gamma complex (composed of gamma, delta, delta', psi and chi chains)
CC and with the beta chain to form the complete DNA polymerase III
CC complex. {ECO:0000256|RuleBase:RU364063}.
CC -!- SIMILARITY: Belongs to the DnaX/STICHEL family.
CC {ECO:0000256|RuleBase:RU364063}.
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DR EMBL; CP017832; AOZ97869.1; -; Genomic_DNA.
DR RefSeq; WP_071177628.1; NZ_CP017832.1.
DR AlphaFoldDB; A0A1D9P5Q3; -.
DR KEGG; bhu:bhn_II070; -.
DR OrthoDB; 9810148at2; -.
DR Proteomes; UP000179284; Plasmid pnp144.
DR GO; GO:0009360; C:DNA polymerase III complex; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR CDD; cd00009; AAA; 1.
DR Gene3D; 1.10.8.60; -; 1.
DR Gene3D; 1.20.272.10; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR008921; DNA_pol3_clamp-load_cplx_C.
DR InterPro; IPR022754; DNA_pol_III_gamma-3.
DR InterPro; IPR012763; DNA_pol_III_sug/sutau_N.
DR InterPro; IPR027417; P-loop_NTPase.
DR NCBIfam; TIGR02397; dnaX_nterm; 1.
DR PANTHER; PTHR11669:SF0; PROTEIN STICHEL; 1.
DR PANTHER; PTHR11669; REPLICATION FACTOR C / DNA POLYMERASE III GAMMA-TAU SUBUNIT; 1.
DR Pfam; PF13177; DNA_pol3_delta2; 1.
DR Pfam; PF12169; DNA_pol3_gamma3; 1.
DR SMART; SM00382; AAA; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF48019; post-AAA+ oligomerization domain-like; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|RuleBase:RU364063};
KW DNA replication {ECO:0000256|RuleBase:RU364063};
KW DNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022932,
KW ECO:0000256|RuleBase:RU364063};
KW Nucleotide-binding {ECO:0000256|RuleBase:RU364063};
KW Nucleotidyltransferase {ECO:0000256|RuleBase:RU364063};
KW Plasmid {ECO:0000313|EMBL:AOZ97869.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000179284};
KW Transferase {ECO:0000256|RuleBase:RU364063}.
FT DOMAIN 34..174
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
SQ SEQUENCE 552 AA; 59893 MW; 623780EB19AB897C CRC64;
MSLYNELRPK SLSEVQGQDT IKAQLKGMFL SKKVPNAMLF NGPRGTGKTT VARIVARTLN
CESGGMEPCG ECQQCKDILN GSSLDVIELD AASNNKVEDV RGIIEKAQYI SSSNYKVFIL
DEVHMFSQGA WNALLKLIEE PPKNVVFIMC TTEEHKVPKT IISRARRFNF ETISLDVISD
YLMQVCNEHG KAYDVDAIRL IAAASDGGMR DALSILEPFY DDDCITTSVV TETLGITPEK
AIFDLLFSIE KGDVASAISV VRDAVTKGKN LQVMLKSIIN TLTDALFVMT GASVETLVNT
DSYRELLLSY VEKVDVDSIL KLSKSLSDVY GVLAKVPDSE FLIETALIRA VNDMASQISL
KEIERRVSDL EKGVSSMPVD VKPVDVQVDN VVNIATKEVS SNDTNEEPAD GFAPISESDE
LPFVLDEIPD ELPIDGDLSV AAVSEMQVNE PVPQSVSESV VDVPSDSSTA VAATSNTIPD
ELLSHLPAGT KVLGEAISST VETPCESDSE DTNVVNDLAG EVKEEAEETA MFKADEEIPA
FGFANSFSGW LQ
//
