ID A0A1D9P789_9FLAO Unreviewed; 436 AA.
AC A0A1D9P789;
DT 15-FEB-2017, integrated into UniProtKB/TrEMBL.
DT 15-FEB-2017, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE RecName: Full=Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex {ECO:0000256|RuleBase:RU003423};
DE EC=2.3.1.- {ECO:0000256|RuleBase:RU003423};
GN ORFNames=BIW12_01305 {ECO:0000313|EMBL:AOZ98184.1};
OS Flavobacterium commune.
OC Bacteria; Bacteroidota; Flavobacteriia; Flavobacteriales;
OC Flavobacteriaceae; Flavobacterium.
OX NCBI_TaxID=1306519 {ECO:0000313|EMBL:AOZ98184.1, ECO:0000313|Proteomes:UP000178198};
RN [1] {ECO:0000313|EMBL:AOZ98184.1, ECO:0000313|Proteomes:UP000178198}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PK15 {ECO:0000313|EMBL:AOZ98184.1,
RC ECO:0000313|Proteomes:UP000178198};
RA Ekwe A., Kim S.B.;
RT "Complete Genome Sequence of Flavobacterium sp. PK15.";
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=(R)-lipoate; Xref=ChEBI:CHEBI:83088;
CC Evidence={ECO:0000256|ARBA:ARBA00001938,
CC ECO:0000256|RuleBase:RU003423};
CC -!- SIMILARITY: Belongs to the 2-oxoacid dehydrogenase family.
CC {ECO:0000256|ARBA:ARBA00007317, ECO:0000256|RuleBase:RU003423}.
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DR EMBL; CP017774; AOZ98184.1; -; Genomic_DNA.
DR RefSeq; WP_071183456.1; NZ_CP017774.1.
DR AlphaFoldDB; A0A1D9P789; -.
DR STRING; 1306519.BIW12_01305; -.
DR KEGG; fcm:BIW12_01305; -.
DR OrthoDB; 9805770at2; -.
DR Proteomes; UP000178198; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProt.
DR GO; GO:0016746; F:acyltransferase activity; IEA:UniProtKB-KW.
DR CDD; cd06849; lipoyl_domain; 1.
DR Gene3D; 2.40.50.100; -; 1.
DR Gene3D; 3.30.559.10; Chloramphenicol acetyltransferase-like domain; 1.
DR Gene3D; 4.10.320.10; E3-binding domain; 1.
DR InterPro; IPR003016; 2-oxoA_DH_lipoyl-BS.
DR InterPro; IPR001078; 2-oxoacid_DH_actylTfrase.
DR InterPro; IPR000089; Biotin_lipoyl.
DR InterPro; IPR023213; CAT-like_dom_sf.
DR InterPro; IPR036625; E3-bd_dom_sf.
DR InterPro; IPR004167; PSBD.
DR InterPro; IPR011053; Single_hybrid_motif.
DR PANTHER; PTHR43178; DIHYDROLIPOAMIDE ACETYLTRANSFERASE COMPONENT OF PYRUVATE DEHYDROGENASE COMPLEX; 1.
DR PANTHER; PTHR43178:SF5; LIPOAMIDE ACYLTRANSFERASE COMPONENT OF BRANCHED-CHAIN ALPHA-KETO ACID DEHYDROGENASE COMPLEX, MITOCHONDRIAL; 1.
DR Pfam; PF00198; 2-oxoacid_dh; 1.
DR Pfam; PF00364; Biotin_lipoyl; 1.
DR Pfam; PF02817; E3_binding; 1.
DR SUPFAM; SSF52777; CoA-dependent acyltransferases; 1.
DR SUPFAM; SSF47005; Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex; 1.
DR SUPFAM; SSF51230; Single hybrid motif; 1.
DR PROSITE; PS50968; BIOTINYL_LIPOYL; 1.
DR PROSITE; PS00189; LIPOYL; 1.
DR PROSITE; PS51826; PSBD; 1.
PE 3: Inferred from homology;
KW Acyltransferase {ECO:0000256|RuleBase:RU003423};
KW Lipoyl {ECO:0000256|ARBA:ARBA00022823, ECO:0000256|RuleBase:RU003423};
KW Reference proteome {ECO:0000313|Proteomes:UP000178198};
KW Transferase {ECO:0000256|RuleBase:RU003423}.
FT DOMAIN 3..78
FT /note="Lipoyl-binding"
FT /evidence="ECO:0000259|PROSITE:PS50968"
FT DOMAIN 127..167
FT /note="Peripheral subunit-binding (PSBD)"
FT /evidence="ECO:0000259|PROSITE:PS51826"
SQ SEQUENCE 436 AA; 47556 MW; 1841442A502C7A6F CRC64;
MARFELKLPR MGESVAEATI TNWLKQVGDK IEADEAVLEV ATDKVDSEVP SEVSGVLIEQ
LFSKDDLVEV GQTIAIIETE GEEAVVEVEI EETIAPEIIE EVTKTIEIAK ETVATPVTIT
NSGSEKFFSP LVKNIAAAEG IGMEELEKIP GTGSEGRVTK NDILEYLKNR TNAPQVEAAK
EVVEVVEAVS SKSVAPVSVS GGDEIIEMDR MRKLIAGYMI SSQQTSAHVY SFIEVDMTNI
VKWREKHKNE FEKREGEKLT FTPIFMEAVA KALKDYPGMN ISVDGDYIIK KKNINLGMAA
ALPNGNLIVP VIKNADQLNL VGMAKAVNDL GNRAKLGKLK PDETKGGTYT VTNVGSFGSI
FGTPILNQPE VGILALGAIR KVPAVIETPE GDFIGIRQKM FLTHGYDHRI IDGALGGMFV
KRVAEYLENF DITRTI
//
