ID A0A1D9P8J4_9FLAO Unreviewed; 337 AA.
AC A0A1D9P8J4;
DT 15-FEB-2017, integrated into UniProtKB/TrEMBL.
DT 15-FEB-2017, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE RecName: Full=UDP-glucose 4-epimerase {ECO:0000256|ARBA:ARBA00018569, ECO:0000256|RuleBase:RU366046};
DE EC=5.1.3.2 {ECO:0000256|ARBA:ARBA00013189, ECO:0000256|RuleBase:RU366046};
GN ORFNames=BIW12_05315 {ECO:0000313|EMBL:AOZ98901.1};
OS Flavobacterium commune.
OC Bacteria; Bacteroidota; Flavobacteriia; Flavobacteriales;
OC Flavobacteriaceae; Flavobacterium.
OX NCBI_TaxID=1306519 {ECO:0000313|EMBL:AOZ98901.1, ECO:0000313|Proteomes:UP000178198};
RN [1] {ECO:0000313|EMBL:AOZ98901.1, ECO:0000313|Proteomes:UP000178198}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PK15 {ECO:0000313|EMBL:AOZ98901.1,
RC ECO:0000313|Proteomes:UP000178198};
RA Ekwe A., Kim S.B.;
RT "Complete Genome Sequence of Flavobacterium sp. PK15.";
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=UDP-alpha-D-glucose = UDP-alpha-D-galactose;
CC Xref=Rhea:RHEA:22168, ChEBI:CHEBI:58885, ChEBI:CHEBI:66914;
CC EC=5.1.3.2; Evidence={ECO:0000256|ARBA:ARBA00000083,
CC ECO:0000256|RuleBase:RU366046};
CC -!- COFACTOR:
CC Name=NAD(+); Xref=ChEBI:CHEBI:57540;
CC Evidence={ECO:0000256|ARBA:ARBA00001911,
CC ECO:0000256|RuleBase:RU366046};
CC -!- PATHWAY: Carbohydrate metabolism; galactose metabolism.
CC {ECO:0000256|ARBA:ARBA00004947, ECO:0000256|RuleBase:RU366046}.
CC -!- SUBUNIT: Homodimer. {ECO:0000256|RuleBase:RU366046}.
CC -!- SIMILARITY: Belongs to the NAD(P)-dependent epimerase/dehydratase
CC family. {ECO:0000256|ARBA:ARBA00007637, ECO:0000256|RuleBase:RU366046}.
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DR EMBL; CP017774; AOZ98901.1; -; Genomic_DNA.
DR RefSeq; WP_071184147.1; NZ_CP017774.1.
DR AlphaFoldDB; A0A1D9P8J4; -.
DR STRING; 1306519.BIW12_05315; -.
DR KEGG; fcm:BIW12_05315; -.
DR OrthoDB; 9801785at2; -.
DR UniPathway; UPA00214; -.
DR Proteomes; UP000178198; Chromosome.
DR GO; GO:0003978; F:UDP-glucose 4-epimerase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006012; P:galactose metabolic process; IEA:UniProtKB-UniPathway.
DR CDD; cd05247; UDP_G4E_1_SDR_e; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR Gene3D; 3.90.25.10; UDP-galactose 4-epimerase, domain 1; 1.
DR InterPro; IPR016040; NAD(P)-bd_dom.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR005886; UDP_G4E.
DR NCBIfam; TIGR01179; galE; 1.
DR PANTHER; PTHR43725; UDP-GLUCOSE 4-EPIMERASE; 1.
DR PANTHER; PTHR43725:SF51; UDP-GLUCOSE 4-EPIMERASE; 1.
DR Pfam; PF16363; GDP_Man_Dehyd; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 3: Inferred from homology;
KW Carbohydrate metabolism {ECO:0000256|RuleBase:RU366046};
KW Isomerase {ECO:0000256|RuleBase:RU366046};
KW NAD {ECO:0000256|RuleBase:RU366046};
KW Reference proteome {ECO:0000313|Proteomes:UP000178198}.
FT DOMAIN 4..326
FT /note="NAD(P)-binding"
FT /evidence="ECO:0000259|Pfam:PF16363"
SQ SEQUENCE 337 AA; 37148 MW; 03D332985ABAA7F6 CRC64;
MKILVTGGLG FIGSHTVVEL QNEGFEVVVI DNLSNSSEDV LKGIEAITGK KPLFEKLDLR
EKSVVQDFFK RHSDVNGVIH FAASKAVGES VGNPLLYYEN NINSLVYLLQ ELEKKESANF
IFSSSCTVYG QAETMPINED SAIQPAMSPY GNTKQIGEEI ITDVAKVSGI NAVLLRYFNP
IGAHPSVEIG ELPIGVPQNL VPFITQTGIG LRKELMVYGN DYPTPDGTCI RDYIHVVDLA
KAHVIALQRL LNKKNEEKVE TFNLGTGVGS SVLEVINAFE KVSGKKLAYQ IVDRREGDVT
LAYANTDKAN KVLGWKTQLS LEQAMESAWK WEQKIRS
//
