ID A0A1D9PBG4_9FLAO Unreviewed; 923 AA.
AC A0A1D9PBG4;
DT 15-FEB-2017, integrated into UniProtKB/TrEMBL.
DT 15-FEB-2017, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE SubName: Full=Aconitate hydratase {ECO:0000313|EMBL:AOZ99916.1};
GN ORFNames=BIW12_11035 {ECO:0000313|EMBL:AOZ99916.1};
OS Flavobacterium commune.
OC Bacteria; Bacteroidota; Flavobacteriia; Flavobacteriales;
OC Flavobacteriaceae; Flavobacterium.
OX NCBI_TaxID=1306519 {ECO:0000313|EMBL:AOZ99916.1, ECO:0000313|Proteomes:UP000178198};
RN [1] {ECO:0000313|EMBL:AOZ99916.1, ECO:0000313|Proteomes:UP000178198}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PK15 {ECO:0000313|EMBL:AOZ99916.1,
RC ECO:0000313|Proteomes:UP000178198};
RA Ekwe A., Kim S.B.;
RT "Complete Genome Sequence of Flavobacterium sp. PK15.";
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=(2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate = 2-methyl-cis-
CC aconitate + H2O; Xref=Rhea:RHEA:17941, ChEBI:CHEBI:15377,
CC ChEBI:CHEBI:57429, ChEBI:CHEBI:57872; EC=4.2.1.99;
CC Evidence={ECO:0000256|ARBA:ARBA00000118};
CC -!- SIMILARITY: Belongs to the aconitase/IPM isomerase family.
CC {ECO:0000256|ARBA:ARBA00007185}.
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DR EMBL; CP017774; AOZ99916.1; -; Genomic_DNA.
DR RefSeq; WP_071185157.1; NZ_CP017774.1.
DR AlphaFoldDB; A0A1D9PBG4; -.
DR STRING; 1306519.BIW12_11035; -.
DR KEGG; fcm:BIW12_11035; -.
DR OrthoDB; 9758061at2; -.
DR Proteomes; UP000178198; Chromosome.
DR GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
DR GO; GO:0003994; F:aconitate hydratase activity; IEA:UniProtKB-EC.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006099; P:tricarboxylic acid cycle; IEA:InterPro.
DR Gene3D; 3.40.1060.10; Aconitase, Domain 2; 1.
DR Gene3D; 3.30.499.10; Aconitase, domain 3; 2.
DR Gene3D; 3.20.19.10; Aconitase, domain 4; 1.
DR Gene3D; 1.25.40.310; Aconitate B, HEAT-like domain; 1.
DR InterPro; IPR015931; Acnase/IPM_dHydase_lsu_aba_1/3.
DR InterPro; IPR001030; Acoase/IPM_deHydtase_lsu_aba.
DR InterPro; IPR015928; Aconitase/3IPM_dehydase_swvl.
DR InterPro; IPR036008; Aconitase_4Fe-4S_dom.
DR InterPro; IPR015933; Aconitase_B_HEAT-like_dom.
DR InterPro; IPR036288; Aconitase_B_HEAT-like_dom_sf.
DR InterPro; IPR015929; Aconitase_B_swivel.
DR InterPro; IPR015932; Aconitase_dom2.
DR PANTHER; PTHR43160; ACONITATE HYDRATASE B; 1.
DR PANTHER; PTHR43160:SF4; ACONITATE HYDRATASE B; 1.
DR Pfam; PF00330; Aconitase; 1.
DR Pfam; PF06434; Aconitase_2_N; 1.
DR Pfam; PF11791; Aconitase_B_N; 1.
DR SUPFAM; SSF74778; Aconitase B, N-terminal domain; 1.
DR SUPFAM; SSF53732; Aconitase iron-sulfur domain; 1.
DR SUPFAM; SSF52016; LeuD/IlvD-like; 1.
PE 3: Inferred from homology;
KW 4Fe-4S {ECO:0000256|ARBA:ARBA00022485};
KW Iron {ECO:0000256|ARBA:ARBA00023004};
KW Iron-sulfur {ECO:0000256|ARBA:ARBA00023014};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000178198};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884}.
FT DOMAIN 6..162
FT /note="Aconitase B HEAT-like"
FT /evidence="ECO:0000259|Pfam:PF11791"
FT DOMAIN 176..405
FT /note="Aconitase B swivel"
FT /evidence="ECO:0000259|Pfam:PF06434"
FT DOMAIN 410..894
FT /note="Aconitase/3-isopropylmalate dehydratase large
FT subunit alpha/beta/alpha"
FT /evidence="ECO:0000259|Pfam:PF00330"
SQ SEQUENCE 923 AA; 100222 MW; 638D972C3E237F3D CRC64;
MNIYSDYIKE IEERKIQGLH PKPIDDAQLL SEIIAQIKDL DNANREDSLQ FFIYNTLPGT
TSAAGEKAKF LKEIILGESV VKEITPAFAF ELLSHMKGGA SIKVLLDLAL GNDAAIAKEA
ASVLKTQVYL YDADTSRLKE AFENGNAIAK EIIESYAKAE FFTKLPEVAE EIKVVTFIAG
EGDISTDLLS PGNQAHSRSD RELHGKCMIT PQAQEEIKAL QAQHPDKSVM LIAEKGTMGV
GSSRMSGVNN VALWTGKQAS PYIPFVNFAP IVGGTNGISP IFLTTVDVTG GIGLDLKNWV
KKVDAEGNVV RNESGEPILE QAYSVATGTV LTINTKTKKL YNGDQELIDI SRSFTPQKME
FIKAGGSYAI VFGKKLQTFA AKTLGIEAPA VFAPSKEISH EGQGLTAVEK IFNRNAVGTT
PGKVLHAGSD VRVEVNIVGS QDTTGLMTAQ ELESMAATVI SPIVDGAYQS GCHTASVWDK
KAQANIPKLM KFMNDFGLIT ARDPKGVYHS MTDVIHKVLN DITIDEWAII IGGDSHTRMS
KGVAFGADSG TVALALATGE ASMPIPESVK VTFKGEMKSY MDFRDVVHAT QAQMLKQFGG
ENVFQGRIIE VHIGTLTADQ AFTFTDWTAE MKAKASICIS EDETLIESLE IAKGRIQIMI
DKGMDNAKQV LKGLIAKADK RIAEIRSGEK PALTPDANAK YYAEVVVDLD VIAEPMIADP
DVNNADVSKR YTHDTIRPLS FYGGEKKVDL GFIGSCMVHK GDMKILAQML KNIEAQQGKV
EFQAPLVVAP PTYNIVDELK AEGDWEVLQK YSGFEFDDNA PKAAARTEYE NMLYLERPGC
NLCMGNQEKA AKGDTVMATS TRLFQGRVVE DTDTKKGESL LSSTPVVVLS TILGRTPTID
EYTAAVDGIN LTKFAPSHKQ LVK
//
