ID A0A1E2VD44_9GAMM Unreviewed; 736 AA.
AC A0A1E2VD44;
DT 18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT 18-JAN-2017, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE RecName: Full=DNA 3'-5' helicase {ECO:0000256|ARBA:ARBA00034808};
DE EC=5.6.2.4 {ECO:0000256|ARBA:ARBA00034808};
DE AltName: Full=DNA 3'-5' helicase II {ECO:0000256|ARBA:ARBA00034923};
GN ORFNames=BFW38_16755 {ECO:0000313|EMBL:ODC04938.1};
OS Terasakiispira papahanaumokuakeensis.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Oceanospirillales;
OC Terasakiispira.
OX NCBI_TaxID=197479 {ECO:0000313|EMBL:ODC04938.1, ECO:0000313|Proteomes:UP000094291};
RN [1] {ECO:0000313|EMBL:ODC04938.1, ECO:0000313|Proteomes:UP000094291}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PH27A {ECO:0000313|EMBL:ODC04938.1,
RC ECO:0000313|Proteomes:UP000094291};
RA Seilhamer J.J.;
RL Submitted (AUG-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034618};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Couples ATP hydrolysis with the unwinding of duplex DNA by
CC translocating in the 3'-5' direction.; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034617};
CC -!- SIMILARITY: Belongs to the helicase family. UvrD subfamily.
CC {ECO:0000256|ARBA:ARBA00009922}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ODC04938.1}.
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DR EMBL; MDTQ01000001; ODC04938.1; -; Genomic_DNA.
DR RefSeq; WP_068999939.1; NZ_MDTQ01000001.1.
DR AlphaFoldDB; A0A1E2VD44; -.
DR STRING; 197479.BFW38_16755; -.
DR OrthoDB; 9806690at2; -.
DR Proteomes; UP000094291; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR CDD; cd17932; DEXQc_UvrD; 1.
DR CDD; cd18807; SF1_C_UvrD; 1.
DR Gene3D; 1.10.10.160; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR013986; DExx_box_DNA_helicase_dom_sf.
DR InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR014016; UvrD-like_ATP-bd.
DR PANTHER; PTHR11070:SF2; ATP-DEPENDENT DNA HELICASE SRS2; 1.
DR PANTHER; PTHR11070; UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER; 1.
DR Pfam; PF21196; PcrA_UvrD_tudor; 1.
DR Pfam; PF00580; UvrD-helicase; 1.
DR Pfam; PF13361; UvrD_C; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
DR PROSITE; PS51217; UVRD_HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; Reference proteome {ECO:0000313|Proteomes:UP000094291}.
FT DOMAIN 8..285
FT /note="UvrD-like helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51198"
FT DOMAIN 286..573
FT /note="UvrD-like helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51217"
FT BINDING 29..36
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00560"
SQ SEQUENCE 736 AA; 83219 MW; E6D5C725C238CDB0 CRC64;
MDVTAIIESL NAAQREAVCA DEHDQLVLAG AGSGKTRVLV HRIAWLLATA GHSPHDLLAV
TFTNKAAREM RLRLEALLGL NLRSMWVGTF HSLSHRLLRT HWKDAQLPQH FQILDSDDQL
RVIKRLMKDL GVDDDRFPPK QAQWFINGQK DEGRRAAHVL ARGEFERGMA EIYAAYEERC
QQQGLVDFAE LLLRALELLR DTPLLLQHYQ NRFKHILVDE FQDTNTLQYA WLRLLRGPNS
CLMAVGDDDQ SIYGWRGAKI ENIQRFTEDF SGAKTVRLEQ NYRSTGTILD AANALISHNT
GRLGKELWTD GASGEPISVY AAFNEQDEAR FIVDLIQQHV QDGGLRRECA ILYRSNAQSR
TLEETLLRQQ VPYRIYGGQR FYERLEIKNA LAYLRLMVNR DDAPAFERVI NTPTRGIGTT
TLEKLRARAR DEGQSLWQAA IEMISGGLLK GRAATSVQAF IQLIERLDEQ SLPLPLHEQV
ELVLNDTQLM DFHAQEKGEK GQARVENLKE LITAVRQYDP ALPVTMSDDG EINLEGRAAL
EHFLAEATLD AGDTQAEEDQ DAVQMMTLHT AKGLEFPLVF IAGVEEGLFP HQMSIEEGAD
RLEEERRLCY VGITRAMKKL YLTHAESRRI YGRDNLCRPS RFISELPENL LQEVRLRASI
SRPVSARPQV RHQGMAQSQA EEVGLRVGQQ VSHPKFGAGI ILHAEGDGPK TRLLINFDEV
GEKWLVLGFA PLTPLD
//
