ID A0A1E2WUN6_9NOSO Unreviewed; 1461 AA.
AC A0A1E2WUN6;
DT 18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT 18-JAN-2017, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE RecName: Full=histidine kinase {ECO:0000256|ARBA:ARBA00012438};
DE EC=2.7.13.3 {ECO:0000256|ARBA:ARBA00012438};
GN ORFNames=A4S05_26545 {ECO:0000313|EMBL:ODH01976.1};
OS Nostoc sp. KVJ20.
OC Bacteria; Cyanobacteriota; Cyanophyceae; Nostocales; Nostocaceae; Nostoc.
OX NCBI_TaxID=457944 {ECO:0000313|EMBL:ODH01976.1, ECO:0000313|Proteomes:UP000094607};
RN [1] {ECO:0000313|EMBL:ODH01976.1, ECO:0000313|Proteomes:UP000094607}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=KVJ20 {ECO:0000313|EMBL:ODH01976.1,
RC ECO:0000313|Proteomes:UP000094607};
RA Wen L., He K., Yang H.;
RL Submitted (FEB-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + protein L-histidine = ADP + protein N-phospho-L-
CC histidine.; EC=2.7.13.3; Evidence={ECO:0000256|ARBA:ARBA00000085};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ODH01976.1}.
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DR EMBL; LSSA01000051; ODH01976.1; -; Genomic_DNA.
DR RefSeq; WP_069072777.1; NZ_KV757671.1.
DR OrthoDB; 434700at2; -.
DR Proteomes; UP000094607; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0000155; F:phosphorelay sensor kinase activity; IEA:InterPro.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR CDD; cd16922; HATPase_EvgS-ArcB-TorS-like; 1.
DR CDD; cd00082; HisKA; 1.
DR CDD; cd00130; PAS; 2.
DR Gene3D; 1.10.287.130; -; 1.
DR Gene3D; 3.30.450.40; -; 1.
DR Gene3D; 3.40.50.2300; -; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR Gene3D; 3.30.450.20; PAS domain; 3.
DR InterPro; IPR011006; CheY-like_superfamily.
DR InterPro; IPR003018; GAF.
DR InterPro; IPR029016; GAF-like_dom_sf.
DR InterPro; IPR003594; HATPase_C.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR005467; His_kinase_dom.
DR InterPro; IPR003661; HisK_dim/P.
DR InterPro; IPR036097; HisK_dim/P_sf.
DR InterPro; IPR001610; PAC.
DR InterPro; IPR000014; PAS.
DR InterPro; IPR000700; PAS-assoc_C.
DR InterPro; IPR035965; PAS-like_dom_sf.
DR InterPro; IPR013656; PAS_4.
DR InterPro; IPR013767; PAS_fold.
DR InterPro; IPR004358; Sig_transdc_His_kin-like_C.
DR InterPro; IPR001789; Sig_transdc_resp-reg_receiver.
DR NCBIfam; TIGR00229; sensory_box; 2.
DR PANTHER; PTHR43547:SF2; HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE C; 1.
DR PANTHER; PTHR43547; TWO-COMPONENT HISTIDINE KINASE; 1.
DR Pfam; PF13185; GAF_2; 1.
DR Pfam; PF02518; HATPase_c; 1.
DR Pfam; PF00512; HisKA; 1.
DR Pfam; PF00989; PAS; 1.
DR Pfam; PF08448; PAS_4; 1.
DR Pfam; PF13426; PAS_9; 1.
DR Pfam; PF00072; Response_reg; 1.
DR PRINTS; PR00344; BCTRLSENSOR.
DR SMART; SM00065; GAF; 1.
DR SMART; SM00387; HATPase_c; 1.
DR SMART; SM00388; HisKA; 1.
DR SMART; SM00086; PAC; 3.
DR SMART; SM00091; PAS; 4.
DR SMART; SM00448; REC; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR SUPFAM; SSF52172; CheY-like; 1.
DR SUPFAM; SSF55781; GAF domain-like; 1.
DR SUPFAM; SSF47384; Homodimeric domain of signal transducing histidine kinase; 1.
DR SUPFAM; SSF55785; PYP-like sensor domain (PAS domain); 4.
DR PROSITE; PS50109; HIS_KIN; 1.
DR PROSITE; PS50113; PAC; 2.
DR PROSITE; PS50112; PAS; 2.
DR PROSITE; PS50110; RESPONSE_REGULATORY; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:ODH01976.1};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553, ECO:0000256|PROSITE-
KW ProRule:PRU00169}; Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 20..44
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 56..77
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 117..141
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 187..206
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 226..246
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 267..283
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 295..313
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 336..379
FT /note="PAS"
FT /evidence="ECO:0000259|PROSITE:PS50112"
FT DOMAIN 413..462
FT /note="PAC"
FT /evidence="ECO:0000259|PROSITE:PS50113"
FT DOMAIN 459..531
FT /note="PAS"
FT /evidence="ECO:0000259|PROSITE:PS50112"
FT DOMAIN 679..731
FT /note="PAC"
FT /evidence="ECO:0000259|PROSITE:PS50113"
FT DOMAIN 1049..1315
FT /note="Histidine kinase"
FT /evidence="ECO:0000259|PROSITE:PS50109"
FT DOMAIN 1340..1458
FT /note="Response regulatory"
FT /evidence="ECO:0000259|PROSITE:PS50110"
FT COILED 575..602
FT /evidence="ECO:0000256|SAM:Coils"
FT MOD_RES 1389
FT /note="4-aspartylphosphate"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00169"
SQ SEQUENCE 1461 AA; 161061 MW; A2BA2111D7D9A029 CRC64;
MLNVNRLRLQ DILKIPGNSL VAKVASAIPI LVGSLVLVGW WLGIEVLKRG FPGSPATMKV
NTALCFVLCG LSLWLFLRTE EQGSSKERII QNYPHNSTAR NAKGGSLNRL TLLISRVCAI
AVTTIAVLTL CEYVFVWNLG IDELVFRDSP TSIATSHPGR MGVNTALNFM LVSVGVQILI
HPKTQRSYWY AQILALVATL ISFQALMGYA YKVQVLYGLA PYTTSMALHT AVLFILLSIG
ILWARAEQGF MRVVTGDTYG GLLARRLLVA AIAVPFVLGW LIVEGQRAEK YGPAFAVSLF
AIILIVIFTI LVWQSASVIE RLSHQRDLAQ EVVRTYEAKL GSFVDSNVIG ILFGDVYGGI
HKANDEYLRM IGYTREDLLA GRVSWSNLTA PEYRYLDERG VAEAQGNANA ACTPYEKEYI
RKDGSRIPVL VGYVLLGENR EESVAFILDL SDRKQAEAEQ QKLVSLVENS SDFIGITTLE
GQLLYINDAG QKLVGLASLD EARQKAVFDY VMPKDKAYLQ EHILPTVLLQ GRWQGEFGFR
HLQTGQPIPV DYNIFTVTDK NTGQPIALAT VTRNISEQKQ AKEQILQLNR DLQRRITELQ
TLLDVIPIGI GIAEDPECQN IKVNPAFAKQ LGISSDTNAS LSAPSDERPT AFKIYREGRE
LSAEELPMQY SAAHGVEVLD FEIDVIHENG KLVRLLEYVA PLFDEDGKTR GCIGAFLDIT
ERKQAEEILL NQHKWLENVL NLMPRPLLFI EPGTARVTFA NRSADELAGG EFPKGVPAAE
YHTVYHYTDA AGDRIPNEQM PGVRVALGER LDGLEIDWHT PTGVHSLLIF ADTLPAMHGH
PATCILVFQD ISNLKEAQKA LSLGYKRLKL LFDTANDLLS SQQPVILIDS VYRKLADQIG
LDVYFNYLVE DSSQVIRLGS YSGISPELAK EIESLAYGEA ICGTVAQERC AIALENVQQS
TDPKTELLRS LGITAYYGYP LIAQGRLLGT LSFGSRTRLS FTENQKGMMQ AVCDQIAIAM
ERASLIASLQ LQTEQLQEAN RMKDEFLGIL SHELRSPLNA ILGWAQLLQR SKLNETQMAR
ATETIERNAK AQTQLIEDLL DISRMIRGKL RLNVRTCNLV SMIESSLETV SLAAQSKEID
LRFSLIPSKE TPNSDCGLGI NGENLESREV QSQSNQHSEN GKLAENPQFL VSGDFERLQQ
IIWNLLSNAI KFTPTGGRVE VQLSVVSGQE KQQTTDQYAQ IQVIDTGIGI NPDFLPYVFD
RFCQADSSST RSYGGLGLGL AIVRHLVELH GGTVHADSPG KEQGATFTVK LPLLKSSPLC
PCAPLPLCPP ASPPSLLGVR VVVVDDQADT REFITTVLEQ CQAEVKAVGS VPEALQVITQ
WKPDVIVSDI GMPQEDGYSL IRKLRSQPPE LGGNIPAAAL TAYARAEDRM RAIQEGYQLH
LPKPIEAAEL ATVVASLVGR T
//
