ID A0A1E3HAY1_9TREE Unreviewed; 1385 AA.
AC A0A1E3HAY1;
DT 18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT 18-JAN-2017, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE SubName: Full=Translation initiation factor aIF-2 {ECO:0000313|EMBL:ODN73499.1};
GN ORFNames=L202_08003 {ECO:0000313|EMBL:ODN73499.1};
OS Cryptococcus amylolentus CBS 6039.
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Tremellomycetes;
OC Tremellales; Cryptococcaceae; Cryptococcus.
OX NCBI_TaxID=1295533 {ECO:0000313|EMBL:ODN73499.1, ECO:0000313|Proteomes:UP000094065};
RN [1] {ECO:0000313|EMBL:ODN73499.1, ECO:0000313|Proteomes:UP000094065}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS 6039 {ECO:0000313|EMBL:ODN73499.1,
RC ECO:0000313|Proteomes:UP000094065};
RA Cuomo C., Litvintseva A., Heitman J., Chen Y., Sun S., Springer D.,
RA Dromer F., Young S., Zeng Q., Chapman S., Gujja S., Saif S., Birren B.;
RT "Evolution of pathogenesis and genome organization in the Tremellales.";
RL Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the TRAFAC class translation factor GTPase
CC superfamily. Classic translation factor GTPase family. IF-2 subfamily.
CC {ECO:0000256|ARBA:ARBA00007733}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ODN73499.1}.
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DR EMBL; AWGJ01000013; ODN73499.1; -; Genomic_DNA.
DR RefSeq; XP_018989411.1; XM_019142840.1.
DR STRING; 1295533.A0A1E3HAY1; -.
DR GeneID; 30159312; -.
DR OrthoDB; 169393at2759; -.
DR Proteomes; UP000094065; Unassembled WGS sequence.
DR GO; GO:0005525; F:GTP binding; IEA:InterPro.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-KW.
DR CDD; cd03703; aeIF5B_II; 1.
DR CDD; cd01887; IF2_eIF5B; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 2.40.30.10; Translation factors; 2.
DR Gene3D; 3.40.50.10050; Translation initiation factor IF- 2, domain 3; 1.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR005225; Small_GTP-bd_dom.
DR InterPro; IPR000795; T_Tr_GTP-bd_dom.
DR InterPro; IPR015760; TIF_IF2.
DR InterPro; IPR023115; TIF_IF2_dom3.
DR InterPro; IPR036925; TIF_IF2_dom3_sf.
DR InterPro; IPR009000; Transl_B-barrel_sf.
DR NCBIfam; TIGR00231; small_GTP; 1.
DR PANTHER; PTHR43381:SF4; EUKARYOTIC TRANSLATION INITIATION FACTOR 5B; 1.
DR PANTHER; PTHR43381; TRANSLATION INITIATION FACTOR IF-2-RELATED; 1.
DR Pfam; PF00009; GTP_EFTU; 1.
DR Pfam; PF11987; IF-2; 1.
DR PRINTS; PR00315; ELONGATNFCT.
DR SUPFAM; SSF52156; Initiation factor IF2/eIF5b, domain 3; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50447; Translation proteins; 1.
DR PROSITE; PS51722; G_TR_2; 1.
PE 3: Inferred from homology;
KW Initiation factor {ECO:0000256|ARBA:ARBA00022540,
KW ECO:0000313|EMBL:ODN73499.1};
KW Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917};
KW Reference proteome {ECO:0000313|Proteomes:UP000094065}.
FT DOMAIN 781..999
FT /note="Tr-type G"
FT /evidence="ECO:0000259|PROSITE:PS51722"
FT REGION 1..45
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 74..106
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 122..202
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 216..755
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 16..35
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 75..96
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 137..152
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 173..190
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 255..269
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 292..332
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 339..363
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 377..403
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 479..554
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 605..645
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 677..702
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 724..750
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1385 AA; 149172 MW; CE3E8E280EA4B0EC CRC64;
MDQTPNTVDL RIPRATTDRI GPEEIQDRDA GRREQQKSVG FSLGLGSGLG SASGSLAGAN
DAVSDLIWDL GAAEDADDAS QKSEPAEKER QRPRAGNKCT PHLKSLVGSD DIKGCIVLVI
SASPAAPSPN MPPKKGAKKG KKNDDDDIWA SKEAAFESNP QTAAASDDEF SAPPKKAGGK
KDKGGLFDLL DEGEEVSDEE GGGLMASRYG AAIAANAAKK DKKKHKKKAA KFVDEDEDLG
SDAEKPAAVN TKPNLDDEWP EDDVKPKKGK KGKKDKKKAV QDEDYEFDEP ATEEAKPDTA
VDINDEWPEE DVKPKKGKKG KKGGKKAQEE DEEDIDAILE KAAAERRTAE AAAAPKPEKK
PEPEAADEED EAEGGDDDGP KILTKKEKEK LKKEKEKAKK KAQAAAKKAS GAQEDSAQPS
PSATPAPPAD EASDEEGDDV AGGADKKKKK KKKAAAKPEA APAPAKGKKV PAHIAAMQAA
MEEKKRLEEA AQKAAEERQR ELEEEERRLA EEEAAAEAAK AAKKQKEKEK QARLKAEGKA
LTPAQKKERA AAEARKQAML ASGMTVAGLQ EGAPKKKPVY GKKKPQQQKP KEEAPKPKPE
PTPAPAPVEE KKDESEDDWD KSDDEKKVDE ATKGVEKLKV EESEDDWDKS SDDEEAAPAP
APAPVPKAEP KAAPAKKAEP APVPAPASKK AAPAPAPKKA APAPTKPAAK ANGKAAPAPA
EESSEEDSSS EETDSDDDSD SDDDSSDEDS DDELAVRKAQ ALEKIEARRA AAQAAKSKDD
LRSPICCILG HVDTGKTKLL DKVRQTSVQE GEAGGITQQI GATFFPRQAI EEKTAVVNRD
GAYKVQIPGL LIIDTPGHES FSNLRTRGSS LCNIAILVVD ITHGLEPQTI ESLNLLRAGK
TPFIVALNKI DRMYGWKQIP NAGFRETLNS QSKSVKSEFE DRVAKTKLAF AEQGLNAEIF
DENKNLGRNI SLVPTSAVTG EGVPDLLMLL VKLTQERMNA NLMYISELEC TILEVKVIEG
LGTTIDVVLN NGVMREGDKI VLCGTDGPIV TQVRALLTPQ PMREMRIKGT YVHHKEVKAA
LGVKISAPGL EKAIAGARLY VAQDDDEVEA YKDMAMDDLT SLAKFVTKTG KGVWVQASTL
GSLEALLTFL EQMKIPVFNF GIGPIHKSTI VKAGTMLDKA PEYAVILAFD VQIEKEASDL
AAKAGLKIFS AEIIYHLFDA FTKYMDEVTE ARKKEAAPHA VWPVRLKIIK AFAHRDPIIL
GCDIIEGTMR TGTPMGVVKV DKETGKREIV ALGKITSIEI NHKPFEIVKR NQIGAGAAVK
IERASYQPAK LYGRQYVKFC LLLQCKLSRC SALTTRTRLC LSSPVNLSTL SSPPSETRWS
CLTGL
//
