ID   A0A1E3HPG3_9TREE        Unreviewed;       941 AA.
AC   A0A1E3HPG3;
DT   18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT   18-JAN-2017, sequence version 1.
DT   28-JUN-2023, entry version 19.
DE   RecName: Full=Nitrogen permease regulator 3 {ECO:0000256|RuleBase:RU368069};
DE   AltName: Full=Required for meiotic nuclear division protein 11 {ECO:0000256|RuleBase:RU368069};
GN   ORFNames=L203_06172 {ECO:0000313|EMBL:ODN78249.1};
OS   Cryptococcus depauperatus CBS 7841.
OC   Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Tremellomycetes;
OC   Tremellales; Cryptococcaceae; Cryptococcus.
OX   NCBI_TaxID=1295531 {ECO:0000313|EMBL:ODN78249.1, ECO:0000313|Proteomes:UP000094043};
RN   [1] {ECO:0000313|EMBL:ODN78249.1, ECO:0000313|Proteomes:UP000094043}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CBS 7841 {ECO:0000313|EMBL:ODN78249.1,
RC   ECO:0000313|Proteomes:UP000094043};
RA   Cuomo C., Litvintseva A., Heitman J., Chen Y., Sun S., Springer D.,
RA   Dromer F., Young S., Zeng Q., Chapman S., Gujja S., Saif S., Birren B.;
RT   "Evolution of pathogenesis and genome organization in the Tremellales.";
RL   Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Mediates inactivation of the TORC1 complex in response to
CC       amino acid starvation. Required for meiotic nuclear division.
CC       {ECO:0000256|RuleBase:RU368069}.
CC   -!- SUBCELLULAR LOCATION: Vacuole membrane {ECO:0000256|RuleBase:RU368069};
CC       Peripheral membrane protein {ECO:0000256|RuleBase:RU368069}.
CC   -!- SIMILARITY: Belongs to the NPR3 family. {ECO:0000256|ARBA:ARBA00010546,
CC       ECO:0000256|RuleBase:RU368069}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:ODN78249.1}.
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DR   EMBL; AWGK01000033; ODN78249.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1E3HPG3; -.
DR   STRING; 1295531.A0A1E3HPG3; -.
DR   VEuPathDB; FungiDB:L203_06172; -.
DR   OrthoDB; 1381214at2759; -.
DR   Proteomes; UP000094043; Unassembled WGS sequence.
DR   GO; GO:0005774; C:vacuolar membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0051321; P:meiotic cell cycle; IEA:UniProtKB-UniRule.
DR   GO; GO:0032007; P:negative regulation of TOR signaling; IEA:InterPro.
DR   InterPro; IPR005365; Npr3.
DR   PANTHER; PTHR13153; CGTHBA PROTEIN -14 GENE PROTEIN; 1.
DR   PANTHER; PTHR13153:SF5; GATOR COMPLEX PROTEIN NPRL3; 1.
DR   Pfam; PF03666; NPR3; 1.
PE   3: Inferred from homology;
KW   Meiosis {ECO:0000256|RuleBase:RU368069};
KW   Reference proteome {ECO:0000313|Proteomes:UP000094043};
KW   Signal {ECO:0000256|RuleBase:RU368069, ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..17
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           18..941
FT                   /note="Nitrogen permease regulator 3"
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5009129269"
FT   REGION          45..139
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          155..179
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          270..299
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          555..586
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        50..75
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        89..108
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        120..139
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        272..295
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   941 AA;  106506 MW;  AB8FF0B9D93DDCB7 CRC64;
     MAENILGLLL ITSSSAGQHV FRYPPDPASP NIRLAQPIYP PATFTATETD IDFRHPRAGG
     AGFRRHTHDD RSSSASVRRS LFGPSTKGSS KNERDKRGKK KPDDLRARYM NPRAQGALSD
     YGEDSEHNDS SSSSEEDDSD FDFLWKTGAL FHTNEGTGPA KSVQIQASKD DEPKLSGMRS
     LDHSTLLDTS RRGSSSTTTA TVAGVERTHD YAEKDAKKAI RAQYNYALGW SLDVLADMLT
     PPRSACNRRF ELSVGNVVFL GHPVCAGPDG KWEAPPDEDE LEERVPSRGR RRMRDSAAPL
     TSLNKVDEGK EASTSAINKN SDVLTKCGDH SDDSHDDIPN LTMFHLVLII DKPDPKPGHE
     SHEEHHSQTP GIYDEIYREI AFKWTAAAYT LQCQSNLIAK ETWMIIKYKE KCLNEGVGII
     DCCQWTAAHC HVERTLSYLY LRLHKFRNQP VNGFHSYLPT TITNHLANIT IHSVLSPKPI
     NTDEAWAHWG EMENMMSDYS DEESEDDWGM PLVGIRKSEL TVRPWQTLLL LETDDSQKQD
     AISFGIAGLP AETEDYGNTI DGGQKSPSKN SKSRRGSRTT KYTNEDCGQE NDEMVLIKTL
     IEACDVTKPL YEIAHLIRYD LEGVVIPLAR ELVQDKRAIL IDVVNTRLRT VVMATTADQH
     STSFSQYTAR FTRDFPELPT FPRFISAVSL APVPFRKIIP NPEPDHATRQ LYMSALLWLL
     RHDLVVQVHT RARVYAKREI KIEAWKRLWY RRRQRWIEAT KEHESEVRRA PSGSDLVTSR
     ASESFPSSTF DAALSINNNH NMSTVPPPNL GSHLDQNRNE NQLCLDYDPA LEMDSDEEFD
     GINGNQNFSL EAEHPHKNEI PNFESTFIYK PARAQKEEAR WLRVIREGAD ELWASKFDLC
     VQYFDGMTTF EEIIYRTGLP RKELEKILQL YNGDVVTFIH P
//