ID A0A1E3I3G3_9TREE Unreviewed; 264 AA.
AC A0A1E3I3G3;
DT 18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT 18-JAN-2017, sequence version 1.
DT 27-MAR-2024, entry version 14.
DE RecName: Full=D-lactate dehydratase {ECO:0000256|ARBA:ARBA00013134};
DE EC=4.2.1.130 {ECO:0000256|ARBA:ARBA00013134};
GN ORFNames=L202_01303 {ECO:0000313|EMBL:ODN83089.1};
OS Cryptococcus amylolentus CBS 6039.
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Tremellomycetes;
OC Tremellales; Cryptococcaceae; Cryptococcus.
OX NCBI_TaxID=1295533 {ECO:0000313|EMBL:ODN83089.1, ECO:0000313|Proteomes:UP000094065};
RN [1] {ECO:0000313|EMBL:ODN83089.1, ECO:0000313|Proteomes:UP000094065}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS 6039 {ECO:0000313|EMBL:ODN83089.1,
RC ECO:0000313|Proteomes:UP000094065};
RA Cuomo C., Litvintseva A., Heitman J., Chen Y., Sun S., Springer D.,
RA Dromer F., Young S., Zeng Q., Chapman S., Gujja S., Saif S., Birren B.;
RT "Evolution of pathogenesis and genome organization in the Tremellales.";
RL Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + methylglyoxal = (R)-lactate + H(+);
CC Xref=Rhea:RHEA:27754, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:16004, ChEBI:CHEBI:17158; EC=4.2.1.130;
CC Evidence={ECO:0000256|ARBA:ARBA00001524};
CC -!- SIMILARITY: Belongs to the peptidase C56 family. HSP31-like subfamily.
CC {ECO:0000256|ARBA:ARBA00038493}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ODN83089.1}.
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DR EMBL; AWGJ01000002; ODN83089.1; -; Genomic_DNA.
DR RefSeq; XP_018997089.1; XM_019134662.1.
DR AlphaFoldDB; A0A1E3I3G3; -.
DR STRING; 1295533.A0A1E3I3G3; -.
DR GeneID; 30152612; -.
DR OrthoDB; 4342at2759; -.
DR Proteomes; UP000094065; Unassembled WGS sequence.
DR GO; GO:0019172; F:glyoxalase III activity; IEA:UniProt.
DR CDD; cd03141; GATase1_Hsp31_like; 1.
DR Gene3D; 3.40.50.880; -; 1.
DR InterPro; IPR029062; Class_I_gatase-like.
DR InterPro; IPR002818; DJ-1/PfpI.
DR PANTHER; PTHR48094:SF11; GLUTATHIONE-INDEPENDENT GLYOXALASE HSP31-RELATED; 1.
DR PANTHER; PTHR48094; PROTEIN/NUCLEIC ACID DEGLYCASE DJ-1-RELATED; 1.
DR Pfam; PF01965; DJ-1_PfpI; 1.
DR SUPFAM; SSF52317; Class I glutamine amidotransferase-like; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000094065};
KW Stress response {ECO:0000256|ARBA:ARBA00023016}.
FT DOMAIN 65..251
FT /note="DJ-1/PfpI"
FT /evidence="ECO:0000259|Pfam:PF01965"
SQ SEQUENCE 264 AA; 28815 MW; 421C8ACAE4AD93D9 CRC64;
MSSGRYIYNQ RSLYNISLSK DIYRTRNHIA NTMSKTGAIL FVFTSADKLL NGAATGWYLP
EAAHPYYALA PHFRIDSVSP NGGEAPIDDN SVKMFTDEES QRFLNDTKAQ ELYKKTQKVA
DVNAADYDAI FVIGGHGPLI DLAKSTEFAK LVEDFYTSKK PVAAVCHGPG ALVLAKNPAT
SKSIISGVNV TGFSNAEEAQ TPYNDFVNIL PFSLEDKLQE LGGKYSKAEQ DWGVKVIWDQ
GVLTGQNPAS AGPLGEKLRE ILLA
//
