ID A0A1E3I529_9TREE Unreviewed; 3680 AA.
AC A0A1E3I529;
DT 18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT 18-JAN-2017, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE RecName: Full=Non-specific serine/threonine protein kinase {ECO:0008006|Google:ProtNLM};
GN ORFNames=L202_01173 {ECO:0000313|EMBL:ODN82926.1};
OS Cryptococcus amylolentus CBS 6039.
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Tremellomycetes;
OC Tremellales; Cryptococcaceae; Cryptococcus.
OX NCBI_TaxID=1295533 {ECO:0000313|EMBL:ODN82926.1, ECO:0000313|Proteomes:UP000094065};
RN [1] {ECO:0000313|EMBL:ODN82926.1, ECO:0000313|Proteomes:UP000094065}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS 6039 {ECO:0000313|EMBL:ODN82926.1,
RC ECO:0000313|Proteomes:UP000094065};
RA Cuomo C., Litvintseva A., Heitman J., Chen Y., Sun S., Springer D.,
RA Dromer F., Young S., Zeng Q., Chapman S., Gujja S., Saif S., Birren B.;
RT "Evolution of pathogenesis and genome organization in the Tremellales.";
RL Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ODN82926.1}.
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DR EMBL; AWGJ01000002; ODN82926.1; -; Genomic_DNA.
DR RefSeq; XP_018996926.1; XM_019134499.1.
DR STRING; 1295533.A0A1E3I529; -.
DR GeneID; 30152482; -.
DR OrthoDB; 3666795at2759; -.
DR Proteomes; UP000094065; Unassembled WGS sequence.
DR CDD; cd05163; PIKK_TRRAP; 1.
DR Gene3D; 1.10.1070.11; Phosphatidylinositol 3-/4-kinase, catalytic domain; 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR003152; FATC_dom.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000403; PI3/4_kinase_cat_dom.
DR InterPro; IPR036940; PI3/4_kinase_cat_sf.
DR InterPro; IPR003151; PIK-rel_kinase_FAT.
DR InterPro; IPR014009; PIK_FAT.
DR InterPro; IPR046807; Tra1_central.
DR InterPro; IPR046805; Tra1_ring.
DR PANTHER; PTHR11139; ATAXIA TELANGIECTASIA MUTATED ATM -RELATED; 1.
DR PANTHER; PTHR11139:SF1; TRANSFORMATION_TRANSCRIPTION DOMAIN-ASSOCIATED PROTEIN; 1.
DR Pfam; PF02259; FAT; 1.
DR Pfam; PF00454; PI3_PI4_kinase; 1.
DR Pfam; PF20175; Tra1_central; 1.
DR Pfam; PF20206; Tra1_ring; 1.
DR SMART; SM00146; PI3Kc; 1.
DR SUPFAM; SSF48371; ARM repeat; 3.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS51189; FAT; 1.
DR PROSITE; PS51190; FATC; 1.
DR PROSITE; PS50290; PI3_4_KINASE_3; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000094065}.
FT DOMAIN 2512..3075
FT /note="FAT"
FT /evidence="ECO:0000259|PROSITE:PS51189"
FT DOMAIN 3320..3648
FT /note="PI3K/PI4K catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50290"
FT DOMAIN 3649..3680
FT /note="FATC"
FT /evidence="ECO:0000259|PROSITE:PS51190"
FT REGION 1..54
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 213..235
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1948..1978
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2939..2963
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3100..3147
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1948..1962
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1963..1978
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3680 AA; 416284 MW; FB5E130CE7CB9BFC CRC64;
MASSAPSTNR SGRPRKSSTA ASHPHPSETP TPSAAGGGAT SMPPPSHTSN GPMSVSDCEF
LASQLLEPSF PTRKKLEIAL ELRDSAENNR DFGFYDKYLS VFVPALISIL GDEKSITFVK
DNVEQRFRHT LLAFLQRLPH TEPFRHHMSS VMELCVKLLK IENEENALLC IKIMIDGLRS
NKDQMEPYTE PFLDLVKQMY ANIKAVVEKE FGTSGSGPKA SAAQGEAAAN GQSHTTLPHA
LHSPKVLTEC PIAVVLIFQT YKSIMQTAML DFYPLVIDSI KIQPEPQRLA HQEASEKGEI
FVGVASGITN REMFAELVKA QVKTMAFLAY VLRGNQGNNR DYVNVFPEAC ARLLRDCPPE
DVITRKELLV ATRHILTVDS RSSFIPYIDI LLEERVLVGT GVSSREMLRP LAYSVVADLI
HHVRNELPLQ QLIRVVYVFS CNLNDSTFSS SIQTMCAKLL NTIIDSIYHK ADTNEMSRIL
KGMFFTFLEK LSAMSDAHER LKGLSVREKE KGKLKEKTED EDVEVTDASE ASADRLAHGW
RDIEQAMPVH SVAYANESVE TFCRDSRYLF KTILHTFRTL LSYTRQGDNP PPQPDGEVLS
RFFECSLKCF AIFDGINRDP REAKEALEML SEIILLFEPH VFAEVWSSHM EFFSELSISN
SQVFSLLQMV ITHEAVSHQL VSILLKYLMA KLPKVGSMDK ANASLTLKMF KIAFLAINTY
INSNESVLVP HLQKLIMSSF ESAAKAEDSS FYYQILRALF RSIGGGRFEA LYKEVLPILQ
EMLDHLAYLL DHPPDEVQSD IFVELMLTVP VRLTNLLPHL SYLMKPLVRA LSAGPDLVSQ
GLRTLELCID NLTADFLDPT LLPVLRDLMA ALHQLLKPVP ANREHANAAL KILGKLGGRN
RRFQEVYDNL EYQLLSDKIT MPITFEGSHH QLELMSLVQT AGMAIDDDAE MLKEDGLQVL
MYSALTVFEK GAPVAEGNAT FLTTMTKLFI ACDKPVVGEK ASAFVRDVCM RAFALELGRA
DQKADGAEPT AKSALDHTRR RFLPLTNALS DAFLETLANS KTSERKGLSD LLATIVMVFK
DLALSPRFAS VVDGHRSFDR MVTFFALRLI TLCHEEAWNK KMAGVAAIST FAHKIELSRK
NIIDLELDFI RALLFCLRDA PQDVPRTADD VVELIKHLIR TCQSQEDGKP RLARITDTLV
GELYSQSELA RDAAHQCIEV LAEVTSQSVP DLITNIAKAK LLSVEHGPIY SKPLRALPFA
MQVGNISAVT YLMNLRPSAV EATSEEFVRL LHEVLALADI DDANIITKPA THKQESWLKA
LRICCLRLLK SSMATPDFMN KPNQGQLRAR IIQVYFKHVY SQNPEIVAVA HEGLRDVLQQ
ENRLSRDVLQ KGLRPILVNL ADAKRLSVSG LDGLARFLEL LTNYFKVEIG VKLLDHFKTL
GDHQMLSKAA FAPLEDNHNI ARMSRLVNIF RLLPASAIQY LNDLVANVVE VETILHQSQP
GPFTEYLGRY LDRYHANAVQ NLFDNVRNPR YVWTYRNIIT SGEAPHLVEE LANRAENLCQ
LCFSDTEAID LVLPGLLLVR DLSRVQSSWL SDAEPVLEPM VGVWRMIVSK SRDSKADTTS
YHFQQMPSLL LEMFMSSLEQ QQHIPLLFHV VEAYEVRAAF ERSHVTFFLY QQVALQESVD
YRREVIEYFF NLYESEDVPW AYKTNALRVI VNPTLRVHFA DPNHDQSLIS PQLVQKIASL
MWRPLAVITS SKQREDTHLI EVFALTTLLV QHCSSKVNEA RKEIFKLAWM GINLLEPTVK
LMAYVLAARF MATYDTPVKF VRLTWTGVLR LKDTDNRVLY RQAIDTLASS LSMRDPPPAS
GTPEWAKLLR TVLIEEGHAT NQLVTVCELL VHHPDLFFDY RELYVPHIAN SLGKLAFAQA
ATPELKKLTV DIVELIFNWE KRRMAAKESD AAEAEEGSKR GADPSSDQGT SKKQRIDRAG
TAISVSSGGG WAAPSQVREL MTAHLLRLVS TSADPVTRNG LTKRALMLFK EILGPRGLPN
VHVKLGFFHR TMIQEINATT RPLVANSTEV IAAVAAAVKD TQWVKANLSL LSKLLEKVWV
SHEVDLHEVV TPLTEDLFAE MPADETVEAE PDAKALLTFV QNAVNDGLAA SLRSTLSLPG
SLFLLRTWLK THPKTLQSEG ISIALLKVLG NTIKLHTTTN QAAGAANEPD LVRLIISILD
ILRDRVPDLR EHRKTLYLGV TSLIDKSANL TLCRYLLQLM RHWIIEGPDA AVHGKEKASI
LLRMMNFENK NDVLFQEYLD VVYDIYEQDE LRGSDITHRL EPAFLLGTRS RKPEQRAKFL
DKLENNLPRS LEQRLQYLCS LQNWDTLSDG YWIPQILSQL LGIVDVDEAL IQVPFTQVLD
SDSVLDLSET ATVGHIIRPA RNLIHIDPKL SHDLWVGIFS MCWESLSRSQ QMTFTPYLIK
LLSKSHLQKQ TDMRPNVVQT FLDSLAACTV PVTLPPTLIR FLAKNFNAWY VGFELLTRLT
DVYRGDDGLR ETCASCLSEL YAELCEEDMY YGVARSRCQF PETTGALTFE QNGMWPKAVE
LYEQAQIKAR NNMLPFSEGE YCLWEDHWIL SAQKLQNWEN LTELARIDND SDLLLECAWR
LSDWASSDRL AIDENLSRVV DHPTPRRKTF EAFLALLKAQ NNRDPPNEFL RVLDEAQQIT
LRKWISLPAH MTSAHLPLLQ MCQQCVELGE AARVFDSLQM TNQTNLELRC NSDLKPIFQT
WRDRLPNFWD DISVWSDLLA WRQHIFQAVT KVYHPLVAQP DNATYGYRGF HETAWMINRF
GEVARRHGLL DVCSVSLNKI YMLPNIEISE AFLKLREQAL CFFQKPEKFN EGLENISTTN
LKFFGQPQRA EFLTFKGMFI ARLGQNEEAN AEFAHAIQTD WNLPKAWAEW GRFNDKLYKD
RPEVPTTGPP DGEPGKPKMT DAQWQESYSQ DRSVLASSAV SCYLQAAGLY NNHKSRGLLL
RVLWLLGLDD SHSTISKAFE NYKGDLVIWY WITLIPQLIM SLSHREATHA RLILIRIAKA
FPQALFFPLR VSREDFVTVK KQQQLHQKYV AARQAKAATA NAADGSQTAE KDVKEEPAAS
GADANGSQPP ASGSMPPPSQ SQSQAPRQPW DLVDEIMNLL KTAFPLLALT MEKMVDQISV
RAKPASDEDI YRFFSALLAD AMQQWGARSG LHNDDGELNA QTKDNLAKFA TNLNGDLKVM
IEKDFMADMP KLREYIRRLQ RWRDVYEGNL DDRSKTLPLD QGGCTLIEFN HSKFDDVEIP
GQYVKHVDQS EEFIKISRFA PKAELGRGHG YCFRRITMIG NNGHSYTFHV QMPAARHCRR
EERLTQLFRI MNSVLWKRKE SRRRGLQIHL PTATPLAPQL RLVQSDSSYV SMQEIFEDYA
ASKKMAREET VLTYYDRLKE LHDPSIPRND HRYIQLRAEL MEEIRVKMVP ETIITNYMMK
SMNGPDNLWL MRKQFAAQTA ATMFLTYVCC LSNRTPSRFY VSRKTGLMYM SEILPAFAPG
QPLISSSESV PFRLTPNMQN FVTRAGVEGI ITGTCTAMAR CLTSPEFDLS GTLCLFIRDE
LLIWHNTYLK DSRLDKPLLG HVYRNVDSFI RRVSTMGYIG ENRDRSTSAP PVVHAIVSLI
SQATSAINLA QMGEIYMPWY
//
