ID   A0A1E3IAT1_9TREE        Unreviewed;       758 AA.
AC   A0A1E3IAT1;
DT   18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT   18-JAN-2017, sequence version 1.
DT   27-MAR-2024, entry version 23.
DE   RecName: Full=Translation initiation factor eIF2B subunit epsilon {ECO:0000256|ARBA:ARBA00044144};
DE   AltName: Full=eIF2B GDP-GTP exchange factor subunit epsilon {ECO:0000256|ARBA:ARBA00044345};
GN   ORFNames=L203_04594 {ECO:0000313|EMBL:ODN85720.1};
OS   Cryptococcus depauperatus CBS 7841.
OC   Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Tremellomycetes;
OC   Tremellales; Cryptococcaceae; Cryptococcus.
OX   NCBI_TaxID=1295531 {ECO:0000313|EMBL:ODN85720.1, ECO:0000313|Proteomes:UP000094043};
RN   [1] {ECO:0000313|EMBL:ODN85720.1, ECO:0000313|Proteomes:UP000094043}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CBS 7841 {ECO:0000313|EMBL:ODN85720.1,
RC   ECO:0000313|Proteomes:UP000094043};
RA   Cuomo C., Litvintseva A., Heitman J., Chen Y., Sun S., Springer D.,
RA   Dromer F., Young S., Zeng Q., Chapman S., Gujja S., Saif S., Birren B.;
RT   "Evolution of pathogenesis and genome organization in the Tremellales.";
RL   Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol
CC       {ECO:0000256|ARBA:ARBA00004514}.
CC   -!- SIMILARITY: Belongs to the eIF-2B gamma/epsilon subunits family.
CC       {ECO:0000256|ARBA:ARBA00007878}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:ODN85720.1}.
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DR   EMBL; AWGK01000020; ODN85720.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1E3IAT1; -.
DR   STRING; 1295531.A0A1E3IAT1; -.
DR   VEuPathDB; FungiDB:L203_04594; -.
DR   OrthoDB; 5474157at2759; -.
DR   Proteomes; UP000094043; Unassembled WGS sequence.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR   GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-KW.
DR   GO; GO:0031369; F:translation initiation factor binding; IEA:InterPro.
DR   CDD; cd04197; eIF-2B_epsilon_N; 1.
DR   CDD; cd11558; W2_eIF2B_epsilon; 1.
DR   Gene3D; 1.25.40.180; -; 1.
DR   Gene3D; 2.160.10.10; Hexapeptide repeat proteins; 1.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR035543; eIF-2B_epsilon_N.
DR   InterPro; IPR029044; Nucleotide-diphossugar_trans.
DR   InterPro; IPR003307; W2_domain.
DR   InterPro; IPR044123; W2_eIF2B_epsilon.
DR   PANTHER; PTHR45887; TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT EPSILON; 1.
DR   PANTHER; PTHR45887:SF1; TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT EPSILON; 1.
DR   Pfam; PF02020; W2; 1.
DR   SUPFAM; SSF48371; ARM repeat; 1.
DR   SUPFAM; SSF53448; Nucleotide-diphospho-sugar transferases; 1.
DR   PROSITE; PS51363; W2; 1.
PE   3: Inferred from homology;
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW   Initiation factor {ECO:0000313|EMBL:ODN85720.1};
KW   Protein biosynthesis {ECO:0000313|EMBL:ODN85720.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000094043}.
FT   DOMAIN          568..745
FT                   /note="W2"
FT                   /evidence="ECO:0000259|PROSITE:PS51363"
FT   REGION          456..569
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          736..758
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        520..562
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        737..758
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   758 AA;  83724 MW;  30FBFBCB91AB5D12 CRC64;
     MPPKKHQSRQ EPKQKADQVD EAPLQAVVLA DSYNRRFEVL CADRPRILLP LCSTPLLSWT
     LESLSLSKVK QVFIFCGIHA DKIRAFIATS PYRATLDIHC LASKSANSAG DALRELDDMH
     LLNPENPFIL VHSPLVSNYD LSQMVQAHKK RRETDKNFIM TMGIGHGGRP HSESPIMLIH
     PPSSRLLHYA PQSLSHVQSR LRIPSALFLD PFPKDIDEYE IWSGTSPSST SNSGGYRDLG
     VDICEADVPA LCTENFDYHD LRRHFVNGVL TSELLGKKIA VHVAGEEGDK SDFKFGGGRY
     IERVRDTRTF GEITQDVLRR WAFPLAPDLT EPGGVQYELR SGNIYIARES VVLSRTTALS
     GPLLIGPRST LSQDTIVSQS TLGADCRIGR GTVIKKSYLF DDVKIGNDCD VEECMIGEGV
     VIGDGCKIGK GVLLGNGVRL GKGAVVPDFA RVGREPYAEG GFNSGDSENE DEQEKDKVAP
     LVGEDSVGYL WPNEEEELSS DSDDEGEDTY EHPRNKKLSQ LGRRLSNLSS PTTSVSTLSN
     ASSSTPSTPL SIASSTSLPD MPSLTLDAGP PQVFYREAVD SLQRAWEEDH KIENALLELR
     TLVMGYNAGL DRAREQVINF LLSKVDASGP AASVLASSTK VLSRWGGLIT NLTGSNPVQI
     ILDAQFFVLN HPSYIPIFGI LLRAFYETDI VGEDELIDWR ESKASRGEEL SKDRQNETDS
     WKEIWTRGKG YVDVLESMES EDNEEDESDE EGEFEESD
//