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Entry: A0A1E3IGD2_9TREE
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ID   A0A1E3IGD2_9TREE        Unreviewed;      1065 AA.
AC   A0A1E3IGD2;
DT   18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT   18-JAN-2017, sequence version 1.
DT   08-MAY-2019, entry version 13.
DE   RecName: Full=DNA polymerase {ECO:0000256|RuleBase:RU000442};
DE            EC=2.7.7.7 {ECO:0000256|RuleBase:RU000442};
GN   ORFNames=L203_03428 {ECO:0000313|EMBL:ODN87647.1};
OS   Cryptococcus depauperatus CBS 7841.
OC   Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina;
OC   Tremellomycetes; Tremellales; Cryptococcaceae; Cryptococcus.
OX   NCBI_TaxID=1295531 {ECO:0000313|EMBL:ODN87647.1, ECO:0000313|Proteomes:UP000094043};
RN   [1] {ECO:0000313|EMBL:ODN87647.1, ECO:0000313|Proteomes:UP000094043}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CBS 7841 {ECO:0000313|EMBL:ODN87647.1,
RC   ECO:0000313|Proteomes:UP000094043};
RA   Cuomo C., Litvintseva A., Heitman J., Chen Y., Sun S., Springer D.,
RA   Dromer F., Young S., Zeng Q., Chapman S., Gujja S., Saif S.,
RA   Birren B.;
RT   "Evolution of pathogenesis and genome organization in the
RT   Tremellales.";
RL   Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC         diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-
CC         COMP:11130, Rhea:RHEA-COMP:11131, ChEBI:CHEBI:33019,
CC         ChEBI:CHEBI:61560, ChEBI:CHEBI:83828; EC=2.7.7.7;
CC         Evidence={ECO:0000256|RuleBase:RU000442};
CC   -!- COFACTOR:
CC       Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC         Evidence={ECO:0000256|RuleBase:RU000442};
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|RuleBase:RU000442}.
CC   -!- SIMILARITY: Belongs to the DNA polymerase type-B family.
CC       {ECO:0000256|RuleBase:RU000442}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:ODN87647.1}.
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DR   EMBL; AWGK01000013; ODN87647.1; -; Genomic_DNA.
DR   OrthoDB; 20210at2759; -.
DR   Proteomes; UP000094043; Unassembled WGS sequence.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0000166; F:nucleotide binding; IEA:InterPro.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.132.60; -; 1.
DR   Gene3D; 3.30.420.10; -; 1.
DR   Gene3D; 3.90.1600.10; -; 1.
DR   InterPro; IPR006172; DNA-dir_DNA_pol_B.
DR   InterPro; IPR017964; DNA-dir_DNA_pol_B_CS.
DR   InterPro; IPR006133; DNA-dir_DNA_pol_B_exonuc.
DR   InterPro; IPR006134; DNA-dir_DNA_pol_B_multi_dom.
DR   InterPro; IPR042087; DNA_pol_B_C.
DR   InterPro; IPR023211; DNA_pol_palm_dom_sf.
DR   InterPro; IPR012337; RNaseH-like_sf.
DR   InterPro; IPR036397; RNaseH_sf.
DR   InterPro; IPR025687; Znf-C4pol.
DR   Pfam; PF00136; DNA_pol_B; 1.
DR   Pfam; PF03104; DNA_pol_B_exo1; 1.
DR   Pfam; PF14260; zf-C4pol; 1.
DR   PRINTS; PR00106; DNAPOLB.
DR   SMART; SM00486; POLBc; 1.
DR   SUPFAM; SSF53098; SSF53098; 1.
DR   PROSITE; PS00116; DNA_POLYMERASE_B; 1.
PE   3: Inferred from homology;
KW   4Fe-4S {ECO:0000256|RuleBase:RU000442};
KW   Complete proteome {ECO:0000313|Proteomes:UP000094043};
KW   DNA replication {ECO:0000256|RuleBase:RU000442};
KW   DNA-binding {ECO:0000256|RuleBase:RU000442};
KW   DNA-directed DNA polymerase {ECO:0000256|RuleBase:RU000442};
KW   Iron {ECO:0000256|RuleBase:RU000442};
KW   Iron-sulfur {ECO:0000256|RuleBase:RU000442};
KW   Metal-binding {ECO:0000256|RuleBase:RU000442};
KW   Nucleotidyltransferase {ECO:0000256|RuleBase:RU000442};
KW   Nucleus {ECO:0000256|RuleBase:RU000442};
KW   Reference proteome {ECO:0000313|Proteomes:UP000094043};
KW   Transferase {ECO:0000256|RuleBase:RU000442};
KW   Zinc {ECO:0000256|RuleBase:RU000442};
KW   Zinc-finger {ECO:0000256|RuleBase:RU000442}.
FT   DOMAIN      104    438       DNA_pol_B_exo1. {ECO:0000259|Pfam:
FT                                PF03104}.
FT   DOMAIN      502    932       DNA_pol_B. {ECO:0000259|Pfam:PF00136}.
FT   DOMAIN      970   1042       zf-C4pol. {ECO:0000259|Pfam:PF14260}.
SQ   SEQUENCE   1065 AA;  120225 MW;  96F6FDEB29833AD4 CRC64;
     MAFEEPLVKK RKLDSNAQQE LLGEMLLQHQ LNEDPVEGTL ISWILFSSLT DYTLDSIETS
     AAWPRPAVYP AINPAKDTIT FQQIEIEEST DAIHGPLIRM FGVNQAGNSV MAHVYGFKPY
     FYIAAPSGFL NKDLQPLTDK INVSVSSVGP CVTHCTILNR RSLWGYRGDD TVPFIKITCN
     DPKSISKRGQ IDFNDLFSPD MITYESNIAY TMRFMIDTKI LGMNWIDVTA GYYELLEGSH
     KKSQCQIEVS CSYKHLVSHA PEGEWLNIAP LRVMSFDIEC AGRKGIFPEA NIDPVIQIAA
     MVTRQGESKP FVRNVFTLNT CAHIVGSQVL EFKDERQLLL EWSRFIETVD PDVIIGYNIA
     NFDLPYLLDR AKALKVADFA FLGRMKGIKS EIKETHFSSK AYGQRDSKSV NIEGRLQLDI
     LQVMQRDYKL RSYTLNAVSA HFLGEQKEDV HHSIITELQN GTADSRRRLA VYCLKDAYLP
     QRLMDKLMCF VNYTEMARVT GVPFNYLLSR GQQIKVISQL FRNAADAGYI IPAMKSEGSD
     EQYEGATVIE PNKGFYDVPI ATLDFASLYP SIMMAHNLCY TTLLDKATIE RYKLVESVDY
     IHTPNNDFFA TSNRRKGLLP HILENLLSAR KRAKMDLKVE KDPFRRAVLD GRQLALKISA
     NSVYGFTGAT IGKLPCLAIS SSVTAYGRQM IEFTKKEVES NYTIEKGYDH DAKVIYGDTD
     SVMVRFGCPD LPTAMKLGAE AAELVSTKFI KPIKLEFEKV YFPYLLISKK RYAGLYWTRP
     EKYDKMDTKG IETVRRDNCR LVSTVIETCL FKMLIDRDVK GAEDYVKETI SDLLQNKIDM
     SQLVITKALA KADYAAKQAH VELAERMRKR DAGSAPSLGD RVAYVIVKGV KGAAAYEKSE
     DPLYVLEHNV PIDTRYYLEN QLSKPLMRIF EPVLGERASG LLSGDHTRAI QIATPTVGGL
     MKFAVKTVTC IGCRTPLRSK NESAVCINCR PKLPELYQKQ VSGMSALQID FARLWTQCQR
     CQGSLHQDVI CTSADCPIFY RRTARQKEVA SAVAQLDRFE KETGW
//
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