ID A0A1E3IR70_9TREE Unreviewed; 1332 AA.
AC A0A1E3IR70;
DT 18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT 18-JAN-2017, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=Niemann-Pick C1 protein {ECO:0000313|EMBL:ODN91082.1};
GN ORFNames=L203_01284 {ECO:0000313|EMBL:ODN91082.1};
OS Cryptococcus depauperatus CBS 7841.
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Tremellomycetes;
OC Tremellales; Cryptococcaceae; Cryptococcus.
OX NCBI_TaxID=1295531 {ECO:0000313|EMBL:ODN91082.1, ECO:0000313|Proteomes:UP000094043};
RN [1] {ECO:0000313|EMBL:ODN91082.1, ECO:0000313|Proteomes:UP000094043}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS 7841 {ECO:0000313|EMBL:ODN91082.1,
RC ECO:0000313|Proteomes:UP000094043};
RA Cuomo C., Litvintseva A., Heitman J., Chen Y., Sun S., Springer D.,
RA Dromer F., Young S., Zeng Q., Chapman S., Gujja S., Saif S., Birren B.;
RT "Evolution of pathogenesis and genome organization in the Tremellales.";
RL Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the patched family.
CC {ECO:0000256|ARBA:ARBA00005585}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ODN91082.1}.
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DR EMBL; AWGK01000005; ODN91082.1; -; Genomic_DNA.
DR STRING; 1295531.A0A1E3IR70; -.
DR VEuPathDB; FungiDB:L203_01284; -.
DR OrthoDB; 2786103at2759; -.
DR Proteomes; UP000094043; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015918; P:sterol transport; IEA:UniProt.
DR Gene3D; 1.20.1640.10; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR InterPro; IPR032190; NPC1_N.
DR InterPro; IPR003392; Ptc/Disp.
DR InterPro; IPR000731; SSD.
DR PANTHER; PTHR45727; NPC INTRACELLULAR CHOLESTEROL TRANSPORTER 1; 1.
DR PANTHER; PTHR45727:SF2; NPC INTRACELLULAR CHOLESTEROL TRANSPORTER 1; 1.
DR Pfam; PF16414; NPC1_N; 1.
DR Pfam; PF02460; Patched; 2.
DR SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR PROSITE; PS50156; SSD; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Lipid transport {ECO:0000256|ARBA:ARBA00023055};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000094043};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 237..264
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 587..607
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 662..684
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 690..712
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 765..784
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 790..815
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1134..1152
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1159..1179
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1185..1208
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1229..1250
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1270..1290
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 584..815
FT /note="SSD"
FT /evidence="ECO:0000259|PROSITE:PS50156"
FT REGION 730..749
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1332 AA; 146462 MW; 21BCCAA2398F38E8 CRC64;
MLQGGAREFA PCEGAVVGQA CLAQSFLALT MARPILQADK SLLELMSSVC GPSYIRPNHV
CCTFDQLSTL SDRLQQAAPL ISSCPACINN FRSFYCDFTC SPDQSSFLSI SSTQKTIEGK
AAVKEVDYQI SSVFKQGFFD SCKDVQFGAT NGFAMDLIGG GATNASAFLK YMGDVRPGLG
SPFQINFPDN DDALYPRKPL ICSDASNINA RCTCVDCPSV CPTLPYVPPP SSDRCHVGIV
SCLTFSLLII YSVTIVLGIF YFTWRQTLKT RRKRYEQVAL LDPPHSPTAL GSQNQGLDGL
IGRGDDSESG PSGSIYFRLG RGASLLDPME HIQPKQNMIN ATLRRFFYRL GLFCARRPIV
VFGVTAIVVG LLNVGWRYFE VETNPVRLWV SPTSESALQM KFFDDTFGPF YKSEQVFITQ
PNGSPVTYET LRWWLGVERE IGQLKTKNGI GLEDVCFAPA GQGSPCVVQS VSAWLGENIE
DWGEGWTDRI QECAARPSEC LPPFGQPIDP KLILGGSNHD WLNAKALVIT WVLNNYNDQR
VQPAEEWERV LRDYLSNLKH PELDISYSTG ISLEEELNKS TNTDVKIVIL SYLVMFLYVS
LTLGGGLPPN IIHAFMHYFH RLLIQLGVII RLIEKSPSDQ SISRPSFKII PALLSVNSKF
SLGLFGITIV LIAVSSSVGI FSLLGVKVTL IIAEVIPFLV LAVGVDNVFI LVHELERQNS
LHIVQEPEQG ADTGSIHSNG PQPSGTSLTP EERVARAVAR MGPSIMLSSV TEVVAFALGA
LVPMPAVRNF AIYAAGSVFL GAVMQCTVFV SAMTLDLRRA EGMRIDCFPC VRVRPPLGLY
DNAGPSGEGI VKRFMRTVYA PLLLRNEVKQ LVLVAFGGLF LVATIGIQHI DLGLDQRLAL
PADSHLVAYF NDLDAYLDVG PPVYFVAQGS DPSSRHGQQQ LCGRFTTCAE LSLTNTLEAE
RKRPESSFIT SPPAAWIDDF LQWTNPSFES CCRVRKRDPS VFCSPRDSER LCQPCFAGHD
WDSTMTGLPE GSEFIRYLKQ WLVSPTNEEC PLGGQAPYAS AVKLGPDNKT VIASHFRTYH
TSLKSQADFI DALAAAQRIS TDITHRTGVK VFPYSIFYVF FDQYEHIKSI SVEVLSFAFV
AVLVITSTFL GSWRSGGTVT FTCALAVANV MGVMGYWGIS LNAISLVNLV ISLGIAVEFC
SHIARAFMGA GSGLPLDKLE RKRERDERAL TALTDVGPSV FLGITMTKLI GVSVLALTRS
KLLEVYYFRM WLTLILSGAL HGLVLLPVLL TYTGGQGYSL EDTDEDWVTS QMRRPMEYEY
APFADDDSVR SI
//
