ID A0A1E3IT06_9TREE Unreviewed; 742 AA.
AC A0A1E3IT06;
DT 18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT 18-JAN-2017, sequence version 1.
DT 28-JUN-2023, entry version 27.
DE RecName: Full=ATP-dependent DNA helicase II subunit 1 {ECO:0000256|ARBA:ARBA00021796};
DE EC=3.6.4.12 {ECO:0000256|ARBA:ARBA00012551};
DE AltName: Full=ATP-dependent DNA helicase II subunit Ku70 {ECO:0000256|ARBA:ARBA00031811};
GN ORFNames=L203_00998 {ECO:0000313|EMBL:ODN91747.1};
OS Cryptococcus depauperatus CBS 7841.
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Tremellomycetes;
OC Tremellales; Cryptococcaceae; Cryptococcus.
OX NCBI_TaxID=1295531 {ECO:0000313|EMBL:ODN91747.1, ECO:0000313|Proteomes:UP000094043};
RN [1] {ECO:0000313|EMBL:ODN91747.1, ECO:0000313|Proteomes:UP000094043}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS 7841 {ECO:0000313|EMBL:ODN91747.1,
RC ECO:0000313|Proteomes:UP000094043};
RA Cuomo C., Litvintseva A., Heitman J., Chen Y., Sun S., Springer D.,
RA Dromer F., Young S., Zeng Q., Chapman S., Gujja S., Saif S., Birren B.;
RT "Evolution of pathogenesis and genome organization in the Tremellales.";
RL Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Chromosome, telomere
CC {ECO:0000256|ARBA:ARBA00004574}. Nucleus
CC {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the ku70 family.
CC {ECO:0000256|ARBA:ARBA00005240}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ODN91747.1}.
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DR EMBL; AWGK01000004; ODN91747.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1E3IT06; -.
DR STRING; 1295531.A0A1E3IT06; -.
DR VEuPathDB; FungiDB:L203_00998; -.
DR OrthoDB; 21093at2759; -.
DR Proteomes; UP000094043; Unassembled WGS sequence.
DR GO; GO:0000781; C:chromosome, telomeric region; IEA:UniProtKB-SubCell.
DR GO; GO:0043564; C:Ku70:Ku80 complex; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0003684; F:damaged DNA binding; IEA:InterPro.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0042162; F:telomeric DNA binding; IEA:InterPro.
DR GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-KW.
DR GO; GO:0006303; P:double-strand break repair via nonhomologous end joining; IEA:InterPro.
DR GO; GO:0000723; P:telomere maintenance; IEA:InterPro.
DR CDD; cd00788; KU70; 1.
DR Gene3D; 1.10.1600.10; -; 1.
DR Gene3D; 2.40.290.10; -; 1.
DR Gene3D; 4.10.970.10; Ku70, bridge and pillars; 1.
DR Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR InterPro; IPR006165; Ku70.
DR InterPro; IPR006164; Ku70/Ku80_beta-barrel_dom.
DR InterPro; IPR027388; Ku70_bridge/pillars_dom_sf.
DR InterPro; IPR047087; KU70_core_dom.
DR InterPro; IPR005160; Ku_C.
DR InterPro; IPR005161; Ku_N.
DR InterPro; IPR036361; SAP_dom_sf.
DR InterPro; IPR016194; SPOC-like_C_dom_sf.
DR InterPro; IPR036465; vWFA_dom_sf.
DR PANTHER; PTHR12604; KU AUTOANTIGEN DNA HELICASE; 1.
DR PANTHER; PTHR12604:SF2; X-RAY REPAIR CROSS-COMPLEMENTING PROTEIN 6; 1.
DR Pfam; PF02735; Ku; 1.
DR Pfam; PF03730; Ku_C; 1.
DR Pfam; PF03731; Ku_N; 1.
DR PIRSF; PIRSF003033; Ku70; 1.
DR SMART; SM00559; Ku78; 1.
DR SUPFAM; SSF68906; SAP domain; 1.
DR SUPFAM; SSF100939; SPOC domain-like; 1.
DR SUPFAM; SSF53300; vWA-like; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Chromosome {ECO:0000256|ARBA:ARBA00022454};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA recombination {ECO:0000256|ARBA:ARBA00023172};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Helicase {ECO:0000256|ARBA:ARBA00022806};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000094043};
KW Telomere {ECO:0000256|ARBA:ARBA00022895}.
FT DOMAIN 414..560
FT /note="Ku"
FT /evidence="ECO:0000259|SMART:SM00559"
SQ SEQUENCE 742 AA; 85051 MW; 3E902BAA095D84F9 CRC64;
MSSHVNNTTI PSWDTLEKDE IDNIPDKAEY EYAERDHVLF CIDASVSMHK PRPDVYDEKR
GSLVRGKSAL QQALESVATI ERYKVITGPI DSVALLLYNT DRSMITANSD KYMAGTHVFQ
PLHTINTDEM KRLVKLVQTA KEQYESQSKD KTVETIEPDI LQKAFPAIDQ ELNVADVLRI
CNFMYRDGGA RLTGAKRVFF VTDNDSPQGN TNAAYTSYND LISYGVEIVP FFVDRLGHRF
NPNLYWNNLL NRVPEEYKSE NPDADGLSKL ADALNDLVIK NAPKKRQFDV PLKFGGQDGV
IVIGVSGYSM ISEQTKGQPR YVKMRGPVVK EVDVRTEYTS AETGAILNDS EICQAYQFGD
QATIRNILEP NWWETGQGQD VDQPLMGDIL RQYIERRQSD DKGEMTEQDN EDVKAFLKKQ
REERPRTVTR TRLQFTKEEV MQFKSMGFEP QIKIIGFQSP NHLRFEYNIK HAYFIYPNED
AYVGSTRTFA ALLQSCLKKN RHALALCRFR ENLAPEFCVL IPQQEEIIDG RQDHPPGFHV
VPLPYKDDIR RPPRNMNANI PAEEAQIDAM KDIIKRMRFK SAVYQPSKYP NPALALHFDR
LQALAFEEDW DPEDPSKQDL DKTLPLYEGI HSRAGEFMKA FKLLVEEDER TIGKLSMPMK
RGKDKADVKA GTTLNEWELS DVRSSWKSGT MNKLKVQDLK DWAKFYNVSL GSKPNKANTI
DVISRYLQNE KDTEKSAKKQ KK
//
