ID   A0A1E3L103_9BACL        Unreviewed;       823 AA.
AC   A0A1E3L103;
DT   18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT   18-JAN-2017, sequence version 1.
DT   24-JAN-2024, entry version 18.
DE   SubName: Full=Peptidoglycan synthase FtsI {ECO:0000313|EMBL:ODP26865.1};
GN   ORFNames=PTI45_03590 {ECO:0000313|EMBL:ODP26865.1};
OS   Paenibacillus nuruki.
OC   Bacteria; Bacillota; Bacilli; Bacillales; Paenibacillaceae; Paenibacillus.
OX   NCBI_TaxID=1886670 {ECO:0000313|EMBL:ODP26865.1, ECO:0000313|Proteomes:UP000094578};
RN   [1] {ECO:0000313|EMBL:ODP26865.1, ECO:0000313|Proteomes:UP000094578}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=TI45-13ar {ECO:0000313|EMBL:ODP26865.1,
RC   ECO:0000313|Proteomes:UP000094578};
RA   Kim S.-J.;
RT   "Genome sequencing of Paenibacillus sp. TI45-13ar, isolated from Korean
RT   traditional nuruk.";
RL   Submitted (AUG-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the transpeptidase family.
CC       {ECO:0000256|ARBA:ARBA00007171}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:ODP26865.1}.
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DR   EMBL; MDER01000070; ODP26865.1; -; Genomic_DNA.
DR   RefSeq; WP_069328948.1; NZ_MDER01000070.1.
DR   AlphaFoldDB; A0A1E3L103; -.
DR   STRING; 1886670.PTI45_03590; -.
DR   PATRIC; fig|1886670.3.peg.3618; -.
DR   Proteomes; UP000094578; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0008658; F:penicillin binding; IEA:InterPro.
DR   CDD; cd06576; PASTA_Pbp2x-like_1; 1.
DR   Gene3D; 3.40.710.10; DD-peptidase/beta-lactamase superfamily; 1.
DR   Gene3D; 3.90.1310.10; Penicillin-binding protein 2a (Domain 2); 1.
DR   InterPro; IPR012338; Beta-lactam/transpept-like.
DR   InterPro; IPR005543; PASTA_dom.
DR   InterPro; IPR005311; PBP_dimer.
DR   InterPro; IPR036138; PBP_dimer_sf.
DR   InterPro; IPR001460; PCN-bd_Tpept.
DR   PANTHER; PTHR30627; PEPTIDOGLYCAN D,D-TRANSPEPTIDASE; 1.
DR   PANTHER; PTHR30627:SF1; PEPTIDOGLYCAN D,D-TRANSPEPTIDASE FTSI; 1.
DR   Pfam; PF03793; PASTA; 1.
DR   Pfam; PF03717; PBP_dimer; 1.
DR   Pfam; PF00905; Transpeptidase; 1.
DR   SMART; SM00740; PASTA; 2.
DR   SUPFAM; SSF56601; beta-lactamase/transpeptidase-like; 1.
DR   SUPFAM; SSF56519; Penicillin binding protein dimerisation domain; 1.
DR   SUPFAM; SSF54184; Penicillin-binding protein 2x (pbp-2x), c-terminal domain; 2.
DR   PROSITE; PS51178; PASTA; 1.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000094578};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        7..29
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          607..667
FT                   /note="PASTA"
FT                   /evidence="ECO:0000259|PROSITE:PS51178"
FT   REGION          727..823
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        741..777
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        778..823
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   823 AA;  88567 MW;  2D9C62925A2658B9 CRC64;
     MNKRIKLRTL FIGGCITLFF AVLITKVFWL QVVQSGDWTD KAIKQWTANS NISAKRGTIT
     DRNGNDLAMD APAYNVALNP RVIDKYGIKG DVVSQLHAIL GTDETEIEKQ ATSVLTSGDE
     IGQLRTWREL NSGGRLIDQE KADQINAFVK QLKEKTGQKW DVGVYLSADS KRYYPKNELA
     AHVIGYTNKD GNAVAGIEAY YDEKLKGTDG HIQYLRDKQG DKLPDSKDVY TPAKNGDNLT
     LTIDETIQYY IEQAMKDAYE QLKPESITVI AADPNTMEIL GMANMPTFNP NKFNEVTDPK
     DFRNLAVKAI YEPGSTFKIV TLSGAVQENL FNPNATYQSG SIQVGRTTLH DLNHSGWGTI
     SYLEGLKRSS NVAFVNLGYK MLGAERLRKY IDAFGFGEQT GIETPGEAKG AINFHPNIPT
     EVATAAYGHG LVQVTPIQQL AAISAVANGG KLLTPHLVKS ITDPNTGVTE NTQTKVVRQV
     IDSATSEKVR GYLEQVVSDQ DIGTGRHAYI DGYRVAGKTG TAVKVINGKY DYTKQVVSFV
     GFAPANDPKI AMIVVIDQPS DSKLGGGTAA APVFKKIVSQ VLPYMGISKV FDDGETKPKA
     EVASKKLMAS YTAPTLTGKM LTDAKKKLLA DGISYTTVGS GTKVVKQYPA SGVAMTGGQT
     IYLMTEDPTK MSIPDLKGES LRDALQILSL MKVEVTATGE GYVSEEVEAS SGGRRSVTLT
     LKSARATVTG VDDTEEDPAT SEEATAPKDG ETDGKATSEG SSTDKETSTD PKATESKDPT
     TSDTQTDSST TEGKTGSSTS ESSANQNPAS SLEIPEPTGA PTN
//