ID A0A1E3NG78_9ASCO Unreviewed; 683 AA.
AC A0A1E3NG78;
DT 18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT 18-JAN-2017, sequence version 1.
DT 22-FEB-2023, entry version 26.
DE RecName: Full=Nucleolar complex-associated protein 3 {ECO:0000256|PIRNR:PIRNR028977};
GN ORFNames=PICMEDRAFT_35901 {ECO:0000313|EMBL:ODQ45147.1};
OS Pichia membranifaciens NRRL Y-2026.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Pichiaceae; Pichia.
OX NCBI_TaxID=763406 {ECO:0000313|EMBL:ODQ45147.1, ECO:0000313|Proteomes:UP000094455};
RN [1] {ECO:0000313|EMBL:ODQ45147.1, ECO:0000313|Proteomes:UP000094455}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NRRL Y-2026 {ECO:0000313|EMBL:ODQ45147.1,
RC ECO:0000313|Proteomes:UP000094455};
RX PubMed=27535936; DOI=10.1073/pnas.1603941113;
RA Riley R., Haridas S., Wolfe K.H., Lopes M.R., Hittinger C.T., Goeker M.,
RA Salamov A.A., Wisecaver J.H., Long T.M., Calvey C.H., Aerts A.L.,
RA Barry K.W., Choi C., Clum A., Coughlan A.Y., Deshpande S., Douglass A.P.,
RA Hanson S.J., Klenk H.-P., LaButti K.M., Lapidus A., Lindquist E.A.,
RA Lipzen A.M., Meier-Kolthoff J.P., Ohm R.A., Otillar R.P., Pangilinan J.L.,
RA Peng Y., Rokas A., Rosa C.A., Scheuner C., Sibirny A.A., Slot J.C.,
RA Stielow J.B., Sun H., Kurtzman C.P., Blackwell M., Grigoriev I.V.,
RA Jeffries T.W.;
RT "Comparative genomics of biotechnologically important yeasts.";
RL Proc. Natl. Acad. Sci. U.S.A. 113:9882-9887(2016).
CC -!- FUNCTION: Required for synthesis of 60S ribosomal subunits and the
CC transport of pre-ribosomes from the nucleoplasm to the cytoplasm.
CC {ECO:0000256|PIRNR:PIRNR028977}.
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus
CC {ECO:0000256|ARBA:ARBA00004604, ECO:0000256|PIRNR:PIRNR028977}.
CC -!- SIMILARITY: Belongs to the CBF/MAK21 family.
CC {ECO:0000256|ARBA:ARBA00007797, ECO:0000256|PIRNR:PIRNR028977}.
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DR EMBL; KV454005; ODQ45147.1; -; Genomic_DNA.
DR RefSeq; XP_019016260.1; XM_019162972.1.
DR AlphaFoldDB; A0A1E3NG78; -.
DR STRING; 763406.A0A1E3NG78; -.
DR GeneID; 30179659; -.
DR OrthoDB; 24935at2759; -.
DR Proteomes; UP000094455; Unassembled WGS sequence.
DR GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR GO; GO:0042254; P:ribosome biogenesis; IEA:UniProtKB-KW.
DR InterPro; IPR005612; CCAAT-binding_factor.
DR InterPro; IPR011501; Noc3_N.
DR InterPro; IPR016903; Nucleolar_cplx-assoc_3.
DR PANTHER; PTHR14428; NUCLEOLAR COMPLEX PROTEIN 3; 1.
DR PANTHER; PTHR14428:SF5; NUCLEOLAR COMPLEX PROTEIN 3 HOMOLOG; 1.
DR Pfam; PF03914; CBF; 1.
DR Pfam; PF07540; NOC3p; 1.
DR PIRSF; PIRSF028977; Nucleolar_complex_p3; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000094455};
KW Ribosome biogenesis {ECO:0000256|PIRNR:PIRNR028977}.
FT DOMAIN 154..244
FT /note="Nucleolar complex-associated protein 3 N-terminal"
FT /evidence="ECO:0000259|Pfam:PF07540"
FT DOMAIN 495..674
FT /note="CCAAT-binding factor"
FT /evidence="ECO:0000259|Pfam:PF03914"
FT REGION 1..147
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 13..37
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 47..72
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 112..131
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 683 AA; 78467 MW; C43979C07B9D3A8E CRC64;
MGKRKLKRSS ELRNNKRRKE EDAKLQSSVF SKVESDDEIE NVEMEDGNDE ADRKLEGEYE
EYETKPRKFN DPDANTVEGL PIRTADGTFH RRVIQKEMPK EEEAGDEESE ASSSESESKE
QEHKKGKGDD EELFDEENDE SYQGLTQEEK IIKTKEDIAE MAQLLIENPE ENILQLSRLR
RMSNSKNPFT AKLAILAMVP VFKSISPSYH IRPLSESEKK EKVSREVAKL RLFEQHLVIN
YKHYIDLLAR KAARFSTQPK VTSTDAELGI IATNAACELA TSLRFFNYRK DLFKIITRRV
MKKPQNEFEL KAYKKCISTL DSLLIEDASH GDISLDLVIL LSKSMRRRDY NVDESVVNVF
LSLTVLNDYS PDSNEHDDQP KLKKKDRIHL SKKERKQLKE RKLIDAEMRT AEQAITAEQR
EKNQAQILKM LLTFYLEILK ARPAKLMAAV LESLSKFGSL VNVDLMGDFL QVLREVTEEI
LQNKDLNSSE VRQVLLCIIT SFSLVANLPT KKVVVDLNKF VDYLYSLIPN LALDMNVEFS
HKTLRLVDPL ATTELNLKPS VNISTKAELL LRCLNAIFFN SKSGSSKRAL AFTKRLYLAS
LHLPEKSTIA LLKFMEKLIA RYDEIKTLYS TEDRVQNGVY HPEVDETERA NTEVAVLWEN
VLLDKHYSNS VAMGARHLFK NAK
//
