ID A0A1E3NH45_9ASCO Unreviewed; 586 AA.
AC A0A1E3NH45;
DT 18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT 18-JAN-2017, sequence version 1.
DT 24-JAN-2024, entry version 21.
DE RecName: Full=Thiamine transporter {ECO:0008006|Google:ProtNLM};
GN ORFNames=PICMEDRAFT_17938 {ECO:0000313|EMBL:ODQ45470.1};
OS Pichia membranifaciens NRRL Y-2026.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Pichiaceae; Pichia.
OX NCBI_TaxID=763406 {ECO:0000313|EMBL:ODQ45470.1, ECO:0000313|Proteomes:UP000094455};
RN [1] {ECO:0000313|EMBL:ODQ45470.1, ECO:0000313|Proteomes:UP000094455}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NRRL Y-2026 {ECO:0000313|EMBL:ODQ45470.1,
RC ECO:0000313|Proteomes:UP000094455};
RX PubMed=27535936; DOI=10.1073/pnas.1603941113;
RA Riley R., Haridas S., Wolfe K.H., Lopes M.R., Hittinger C.T., Goeker M.,
RA Salamov A.A., Wisecaver J.H., Long T.M., Calvey C.H., Aerts A.L.,
RA Barry K.W., Choi C., Clum A., Coughlan A.Y., Deshpande S., Douglass A.P.,
RA Hanson S.J., Klenk H.-P., LaButti K.M., Lapidus A., Lindquist E.A.,
RA Lipzen A.M., Meier-Kolthoff J.P., Ohm R.A., Otillar R.P., Pangilinan J.L.,
RA Peng Y., Rokas A., Rosa C.A., Scheuner C., Sibirny A.A., Slot J.C.,
RA Stielow J.B., Sun H., Kurtzman C.P., Blackwell M., Grigoriev I.V.,
RA Jeffries T.W.;
RT "Comparative genomics of biotechnologically important yeasts.";
RL Proc. Natl. Acad. Sci. U.S.A. 113:9882-9887(2016).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the purine-cytosine permease (2.A.39) family.
CC {ECO:0000256|ARBA:ARBA00008974}.
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DR EMBL; KV454005; ODQ45470.1; -; Genomic_DNA.
DR RefSeq; XP_019016583.1; XM_019161815.1.
DR AlphaFoldDB; A0A1E3NH45; -.
DR GeneID; 30178502; -.
DR OrthoDB; 1218881at2759; -.
DR Proteomes; UP000094455; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR CDD; cd11482; SLC-NCS1sbd_NRT1-like; 1.
DR Gene3D; 1.10.4160.10; Hydantoin permease; 1.
DR InterPro; IPR001248; Pur-cyt_permease.
DR InterPro; IPR045225; Uracil/uridine/allantoin_perm.
DR PANTHER; PTHR30618; NCS1 FAMILY PURINE/PYRIMIDINE TRANSPORTER; 1.
DR PANTHER; PTHR30618:SF15; NICOTINAMIDE RIBOSIDE TRANSPORTER 1-RELATED; 1.
DR Pfam; PF02133; Transp_cyt_pur; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000094455};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 40..60
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 72..90
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 102..121
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 169..186
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 192..212
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 274..295
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 329..349
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 361..381
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 393..418
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 477..499
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 586 AA; 65839 MW; B93D15F58BB2A039 CRC64;
MTLADKLRWL EVPHPEKKVL TVLKNPDLEP MPEDRRLWGF WAYFGYWSVP NVSIFTYSIG
SSLLVLGLNI QQTMGAVTIG NILIITYTTL NSTPGSKFKI GFTMCQRMIF GIFGSYLGIL
IRILLSIVYY ASMSWLGALG VVVMLSSWSK SYMNMENTFP EGLNMTKRDF TAFFCFNVIE
FFFFFIKPEK MGPLVNGSCF ITLVAMLGVF GYELHKCYVL TGGPGSMWYE PVSLPKSEIG
WAWLEAVTVF YGAVSPNCTN MSDYSRFSKN SKQMYLGIIL SIAMTGTLIP IMGMVTASNT
LENYGTAMWL PTDVCLQWMA DDYSAGTRAA AFFCGLAFAS SQLTFNVLAN GFAGGMDLSG
IFPRYINIFR GAVITALISW ACQPWNFYNT ASVFNSVMAS FGVVMSPIMG IIISDFHLVR
KRRIRVSHLY SLDKSKDFWY SFGFNWRAYL CFFAAMVPGL PGLAAVVNPS ISLPIGLIHY
FDNSTVFSFF CPLILYYVIC RFFPVQGAGE TDEIDYFDVF TDKELQELSM RPYEEGCEFE
GMLPLDRMHT GSDASDFIEG IDGTDAAGSE NDKDCEKVSY IFQQKR
//
