ID A0A1E3NIS9_9ASCO Unreviewed; 773 AA.
AC A0A1E3NIS9;
DT 18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT 18-JAN-2017, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE RecName: Full=Calcium permeable stress-gated cation channel 1 {ECO:0008006|Google:ProtNLM};
DE Flags: Fragment;
GN ORFNames=PICMEDRAFT_20253 {ECO:0000313|EMBL:ODQ45488.1};
OS Pichia membranifaciens NRRL Y-2026.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Pichiaceae; Pichia.
OX NCBI_TaxID=763406 {ECO:0000313|EMBL:ODQ45488.1, ECO:0000313|Proteomes:UP000094455};
RN [1] {ECO:0000313|EMBL:ODQ45488.1, ECO:0000313|Proteomes:UP000094455}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NRRL Y-2026 {ECO:0000313|EMBL:ODQ45488.1,
RC ECO:0000313|Proteomes:UP000094455};
RX PubMed=27535936; DOI=10.1073/pnas.1603941113;
RA Riley R., Haridas S., Wolfe K.H., Lopes M.R., Hittinger C.T., Goeker M.,
RA Salamov A.A., Wisecaver J.H., Long T.M., Calvey C.H., Aerts A.L.,
RA Barry K.W., Choi C., Clum A., Coughlan A.Y., Deshpande S., Douglass A.P.,
RA Hanson S.J., Klenk H.-P., LaButti K.M., Lapidus A., Lindquist E.A.,
RA Lipzen A.M., Meier-Kolthoff J.P., Ohm R.A., Otillar R.P., Pangilinan J.L.,
RA Peng Y., Rokas A., Rosa C.A., Scheuner C., Sibirny A.A., Slot J.C.,
RA Stielow J.B., Sun H., Kurtzman C.P., Blackwell M., Grigoriev I.V.,
RA Jeffries T.W.;
RT "Comparative genomics of biotechnologically important yeasts.";
RL Proc. Natl. Acad. Sci. U.S.A. 113:9882-9887(2016).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the CSC1 (TC 1.A.17) family.
CC {ECO:0000256|ARBA:ARBA00007779}.
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DR EMBL; KV454005; ODQ45488.1; -; Genomic_DNA.
DR RefSeq; XP_019016601.1; XM_019162155.1.
DR AlphaFoldDB; A0A1E3NIS9; -.
DR STRING; 763406.A0A1E3NIS9; -.
DR GeneID; 30178842; -.
DR OrthoDB; 366603at2759; -.
DR Proteomes; UP000094455; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005227; F:calcium-activated cation channel activity; IEA:InterPro.
DR InterPro; IPR045122; Csc1-like.
DR InterPro; IPR003864; CSC1/OSCA1-like_7TM.
DR InterPro; IPR027815; CSC1/OSCA1-like_cyt.
DR InterPro; IPR032880; Csc1/OSCA1-like_N.
DR PANTHER; PTHR13018:SF83; CALCIUM PERMEABLE STRESS-GATED CATION CHANNEL 1; 1.
DR PANTHER; PTHR13018; PROBABLE MEMBRANE PROTEIN DUF221-RELATED; 1.
DR Pfam; PF14703; PHM7_cyt; 1.
DR Pfam; PF02714; RSN1_7TM; 1.
DR Pfam; PF13967; RSN1_TM; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000094455};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 42..61
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 94..113
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 366..388
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 423..440
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 461..482
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 577..608
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 629..649
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 655..675
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 4..114
FT /note="CSC1/OSCA1-like N-terminal transmembrane"
FT /evidence="ECO:0000259|Pfam:PF13967"
FT DOMAIN 135..354
FT /note="CSC1/OSCA1-like cytosolic"
FT /evidence="ECO:0000259|Pfam:PF14703"
FT DOMAIN 367..648
FT /note="CSC1/OSCA1-like 7TM region"
FT /evidence="ECO:0000259|Pfam:PF02714"
FT REGION 221..251
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 714..773
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 230..251
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 715..729
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:ODQ45488.1"
FT NON_TER 773
FT /evidence="ECO:0000313|EMBL:ODQ45488.1"
SQ SEQUENCE 773 AA; 87676 MW; F1A0A0D8EB4D571D CRC64;
ISNKSFVRSV ATLHRITDDE IIEFAGLDAY VFLGFFKMSI KILSICWLFA TLLISPIRFY
FTGQYDQGDG DAGGPGSPAK DPDGTVESWY RTYLLIYVVF TYLFTYVTCH YLVQHARTVI
EKRQEILGKQ NSITDRTIRL SGIPPEMRTE RILKEVIENL HIGRVEKIVI CKEWKKLDSL
FDRRARVVKN LEFYWSNYFD AGNLTSSDTS NQDSIRLEST RYRDLVPEDS NNPFNDSQNM
EDGNMSASQA TLNSTLSSAT STLSLKTRPS VKLGFMGIFG KKVDAIDHYT NQLSIIDEEI
KNARKYHYAA TPTAFVTMDS VATAQTLAQA VLDPRIGYLI SSPAPAPADI IWENATLPSH
SRKLKIYYIT VITGILGVIF IFPVGYLATL LNMKSIKKFW PDLAGFLLKH QWASKIVIDL
LPVYLYTLLN GVIPFLYVWL SSKQGFISHG EEELSVVSKN FFYVFVNLFL VFTMAGTASN
YWGYLSDSKK LALQLAQSLR GLSSFYVDTI VLQGVGLMPF KLLPIGRIFQ FIFFWLTHNN
FKPSNSLFWR GNPTARELTY LFQPPSFNFG LQLPHPLLTL VITLIYSVIS TKIVSAGLIY
FIIGYYVYKF NLVYTYIHPQ HSTGKVMPII FRRVILGLLL FQLTVAGSLV LEKSWVLAMC
LAPLPLITLM ILWYFQDKLQ PLSVFIALRA IEIDDTNDSN IETGARHDFH SARQHNGFSR
SPFPSKKNKS PTTIDERREQ NQSYEYPPLV GNLEGPWIGI EKGDASSATV DDT
//
