ID A0A1E3NL36_9ASCO Unreviewed; 931 AA.
AC A0A1E3NL36;
DT 18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT 18-JAN-2017, sequence version 1.
DT 24-JAN-2024, entry version 26.
DE RecName: Full=Importin N-terminal domain-containing protein {ECO:0000259|PROSITE:PS50166};
GN ORFNames=PICMEDRAFT_16673 {ECO:0000313|EMBL:ODQ46862.1};
OS Pichia membranifaciens NRRL Y-2026.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Pichiaceae; Pichia.
OX NCBI_TaxID=763406 {ECO:0000313|EMBL:ODQ46862.1, ECO:0000313|Proteomes:UP000094455};
RN [1] {ECO:0000313|EMBL:ODQ46862.1, ECO:0000313|Proteomes:UP000094455}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NRRL Y-2026 {ECO:0000313|EMBL:ODQ46862.1,
RC ECO:0000313|Proteomes:UP000094455};
RX PubMed=27535936; DOI=10.1073/pnas.1603941113;
RA Riley R., Haridas S., Wolfe K.H., Lopes M.R., Hittinger C.T., Goeker M.,
RA Salamov A.A., Wisecaver J.H., Long T.M., Calvey C.H., Aerts A.L.,
RA Barry K.W., Choi C., Clum A., Coughlan A.Y., Deshpande S., Douglass A.P.,
RA Hanson S.J., Klenk H.-P., LaButti K.M., Lapidus A., Lindquist E.A.,
RA Lipzen A.M., Meier-Kolthoff J.P., Ohm R.A., Otillar R.P., Pangilinan J.L.,
RA Peng Y., Rokas A., Rosa C.A., Scheuner C., Sibirny A.A., Slot J.C.,
RA Stielow J.B., Sun H., Kurtzman C.P., Blackwell M., Grigoriev I.V.,
RA Jeffries T.W.;
RT "Comparative genomics of biotechnologically important yeasts.";
RL Proc. Natl. Acad. Sci. U.S.A. 113:9882-9887(2016).
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- SIMILARITY: Belongs to the importin beta family. Importin beta-2
CC subfamily. {ECO:0000256|ARBA:ARBA00038423}.
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DR EMBL; KV454003; ODQ46862.1; -; Genomic_DNA.
DR RefSeq; XP_019017975.1; XM_019161302.1.
DR AlphaFoldDB; A0A1E3NL36; -.
DR STRING; 763406.A0A1E3NL36; -.
DR GeneID; 30177989; -.
DR OrthoDB; 276400at2759; -.
DR Proteomes; UP000094455; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProt.
DR GO; GO:0031267; F:small GTPase binding; IEA:InterPro.
DR GO; GO:0006606; P:protein import into nucleus; IEA:InterPro.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 2.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR021133; HEAT_type_2.
DR InterPro; IPR001494; Importin-beta_N.
DR InterPro; IPR040122; Importin_beta.
DR PANTHER; PTHR10527:SF3; FI21453P1-RELATED; 1.
DR PANTHER; PTHR10527; IMPORTIN BETA; 1.
DR Pfam; PF13513; HEAT_EZ; 1.
DR Pfam; PF03810; IBN_N; 1.
DR SMART; SM00913; IBN_N; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR PROSITE; PS50077; HEAT_REPEAT; 1.
DR PROSITE; PS50166; IMPORTIN_B_NT; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000094455}.
FT DOMAIN 33..100
FT /note="Importin N-terminal"
FT /evidence="ECO:0000259|PROSITE:PS50166"
FT REPEAT 464..500
FT /note="HEAT"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00103"
FT REGION 329..394
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 338..374
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 375..393
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 931 AA; 103712 MW; 6179DA60EDD54E05 CRC64;
MSSSWTPDMA SLQQLVHIFA GTLSPDTAIR QEATSALTQA KSIADFDNYL LHILLASEIN
ESTRASAGIY LKNDLVKNFK FKKPDLQSHI LELLPQGLLS NSTFVRRITS GIISAVFRTV
GPQGWPSVVP DLISLISGAA GADAIDGASE AFLSICEDSA RLLEQEVQSS AGVIVPMQLL
VPRLVEIIAN GSMAAKVRAR ALACLVHCIN VGSHTLYVNI DSILSVVFAL CQQNISDEKI
QGQIAAIFVG ILDKWPEKLY QHWSGVVSWC THMVKEGDES VALQADEFLL SMSTSELPPD
MILPYLEIII PVLLEKMVYD ETDVELMEAE DAKDDGSEDK DEDIKPQMAK SKEHKAIKKE
NEDGNKSNGR GVDATEESDE DDDNEEDNDD DFDNSYTWNL RKCSAATVDM LSTTFPKEVL
QYSFPMIKES MNAQQWPIRE ASILILGAVS EAALQYAAEQ LPELIPFLVD RIKDDQPRVR
QITCWTLSRY AAWVCSEATT GGAFANYFKP TFQAIMDCAL DKKKVVQESA CSSLSDFIEC
SDPQLISQFV EPLLHHFQAY FANYRRKNMI VLYDTVQTFT EKVGEQLRYN PTYVDLLLPP
LIQRWQELDD SDKDLWPLLE CMSSVAASIG EAFAGCAEPV YERAVRILHK CIEEEKMANS
DPTFVAPEKD FIVTSLDLVD GLIQGLTTHS GQLIAQNDSK TSFSLMELVL TCLDDNYYDV
RQSAYALLGD CAIYLFDLLI KPYIQTLMVS IYQEITNLND DAIASCNNAI WALGEIAIRA
DNNLIQQYLS NFFRVLEPLI HDFNADVTLL ENTAVTIGRF GIFYPDQTAV VAQEVLIMWC
ELISGLEDNE EKASAVNGMC NIIMKHPEIA NDLGNVRAII DMIANYHEPS VELAEVFKVL
LEGFKSGLGM EWDRIIGDSP ACQSLRQRYG V
//
