ID A0A1E3NMM3_9ASCO Unreviewed; 1211 AA.
AC A0A1E3NMM3;
DT 18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT 18-JAN-2017, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE RecName: Full=Glycerophosphocholine phosphodiesterase {ECO:0008006|Google:ProtNLM};
GN ORFNames=PICMEDRAFT_57853 {ECO:0000313|EMBL:ODQ47370.1};
OS Pichia membranifaciens NRRL Y-2026.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Pichiaceae; Pichia.
OX NCBI_TaxID=763406 {ECO:0000313|EMBL:ODQ47370.1, ECO:0000313|Proteomes:UP000094455};
RN [1] {ECO:0000313|EMBL:ODQ47370.1, ECO:0000313|Proteomes:UP000094455}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NRRL Y-2026 {ECO:0000313|EMBL:ODQ47370.1,
RC ECO:0000313|Proteomes:UP000094455};
RX PubMed=27535936; DOI=10.1073/pnas.1603941113;
RA Riley R., Haridas S., Wolfe K.H., Lopes M.R., Hittinger C.T., Goeker M.,
RA Salamov A.A., Wisecaver J.H., Long T.M., Calvey C.H., Aerts A.L.,
RA Barry K.W., Choi C., Clum A., Coughlan A.Y., Deshpande S., Douglass A.P.,
RA Hanson S.J., Klenk H.-P., LaButti K.M., Lapidus A., Lindquist E.A.,
RA Lipzen A.M., Meier-Kolthoff J.P., Ohm R.A., Otillar R.P., Pangilinan J.L.,
RA Peng Y., Rokas A., Rosa C.A., Scheuner C., Sibirny A.A., Slot J.C.,
RA Stielow J.B., Sun H., Kurtzman C.P., Blackwell M., Grigoriev I.V.,
RA Jeffries T.W.;
RT "Comparative genomics of biotechnologically important yeasts.";
RL Proc. Natl. Acad. Sci. U.S.A. 113:9882-9887(2016).
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DR EMBL; KV454002; ODQ47370.1; -; Genomic_DNA.
DR RefSeq; XP_019018483.1; XM_019163259.1.
DR AlphaFoldDB; A0A1E3NMM3; -.
DR STRING; 763406.A0A1E3NMM3; -.
DR GeneID; 30179946; -.
DR OrthoDB; 1005457at2759; -.
DR Proteomes; UP000094455; Unassembled WGS sequence.
DR GO; GO:0008081; F:phosphoric diester hydrolase activity; IEA:InterPro.
DR GO; GO:0006629; P:lipid metabolic process; IEA:InterPro.
DR GO; GO:0006796; P:phosphate-containing compound metabolic process; IEA:UniProt.
DR CDD; cd14484; SPX_GDE1_like; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 2.
DR Gene3D; 3.20.20.190; Phosphatidylinositol (PI) phosphodiesterase; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR030395; GP_PDE_dom.
DR InterPro; IPR017946; PLC-like_Pdiesterase_TIM-brl.
DR InterPro; IPR004331; SPX_dom.
DR PANTHER; PTHR22958:SF1; GLYCEROPHOSPHOCHOLINE PHOSPHODIESTERASE GPCPD1; 1.
DR PANTHER; PTHR22958; GLYCEROPHOSPHORYL DIESTER PHOSPHODIESTERASE; 1.
DR Pfam; PF12796; Ank_2; 1.
DR Pfam; PF03009; GDPD; 1.
DR Pfam; PF03105; SPX; 2.
DR SMART; SM00248; ANK; 6.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR SUPFAM; SSF51695; PLC-like phosphodiesterases; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 2.
DR PROSITE; PS50088; ANK_REPEAT; 2.
DR PROSITE; PS51704; GP_PDE; 1.
DR PROSITE; PS50007; PIPLC_X_DOMAIN; 1.
DR PROSITE; PS51382; SPX; 1.
PE 4: Predicted;
KW ANK repeat {ECO:0000256|ARBA:ARBA00023043, ECO:0000256|PROSITE-
KW ProRule:PRU00023}; Reference proteome {ECO:0000313|Proteomes:UP000094455};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 1..156
FT /note="SPX"
FT /evidence="ECO:0000259|PROSITE:PS51382"
FT REPEAT 511..543
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 545..577
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT DOMAIN 860..1202
FT /note="GP-PDE"
FT /evidence="ECO:0000259|PROSITE:PS51704"
SQ SEQUENCE 1211 AA; 136061 MW; E120A6BABD8682C1 CRC64;
MKFGHTLLSH QVPEWQQHYI DYKLLKKIVK SIHNREAEIR LEDRDADVFA DSQIKADLAR
FFFHIDSNVE KVDEFYTKKY LDYERRLKKL IAVFPKTSSD INDMEEYDDL VDILLELRNC
FRNLKWYAEL NRRGFVKILK KLDKKTGTKK QESYLRSKIY PLSFCNDADT VRILSTINDY
LNKLSNIKDE NEFSATSKVS DGSASSSIST LDINPVHNLG GNYNFGTISE QSRLPPPSTV
AVPTINNMLK SSAADPFLHA IKEDDVEKLE SLLTKEYMSP VLAPLKLLLS LLNKSTLELS
YKCIDQLLKI IPVLSDSSDV SGRNFIHHHV IALGKKNYNR TANNYNIGQL SKTDYNASLF
STYGPDGINS NDSSKGLWYI FQNLPDHLKF AILQKDNYKR TPLHYASQYG LKEVTFIVLQ
FLKEWGMFNE NVSLDDISHW GDSENLTPLH LAVLGKHPKT TEVLVDAIAK NISLTCPYLL
HVATRMNTPD LLSCLLKCRG IDINAYETEQ SKETALYVAA KYDLKDSVET LLENGADSEI
GESSFGWTPI FVASANGYND IIELLINYGA KYFIQDESGW TPREHAALRG HIDIIPKLTP
PDFNPYDSLN MVTMSPKLSP KILARNSSAS SSILKIAEHR SKTPEPQSDK IDLKQLQNSN
SSFTHLPVNN NTIVGNRYLK KGESLVLVTI GTTDLRDTTP ALELNKIPLS KIHSTELDSA
LSIVIRSPNV PDQPEYPLAL PLDDNHGSAT DPITFKCNNR NPLDTVLYFD IIPTFEVDVN
DGEKNKKILG RGVAILKDLY TPVGPNKRSL FNCVKVPILE MGTMEVLGSI KFEFLFAKSF
EEVGKIPENA DRYWKSLVHP KLIGHRGNGM NSRNKKSLQL GENTVESFIA AASLGAQYVE
FDVQLTKDDI PVIYHDFIVA ESGFDIPMHS LTLEQFMHLN LDHKNAKADK NKFVKDDSFI
AKRSRSKSVT SGANAKKVGD LETLPVESYE EFDEEDFNQG RMKFTKTWKQ KEFKANTRGA
TIASSFTTLE ELFRKIPKTA GFNIELKYPM LDESQSDDIG QVAPEINHFL DTILSMVYDK
YDGRNVIFSS FHPDVCMIMT MKQPSFPVLF LTEAGVSPMA DVRASSLQCA IRFAKNWNLF
GIVSDALPLV YCPRLAGVVK ASGLACFTYG TANNDPENAK LELAAGVDAV IVDSVLAVRK
ELTNAKNESP G
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