ID A0A1E3P489_WICAA Unreviewed; 1430 AA.
AC A0A1E3P489;
DT 18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT 18-JAN-2017, sequence version 1.
DT 24-JAN-2024, entry version 20.
DE SubName: Full=Glycosyltransferase family 24 protein {ECO:0000313|EMBL:ODQ60014.1};
GN ORFNames=WICANDRAFT_30048 {ECO:0000313|EMBL:ODQ60014.1};
OS Wickerhamomyces anomalus (strain ATCC 58044 / CBS 1984 / NCYC 433 / NRRL
OS Y-366-8) (Yeast) (Hansenula anomala).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Phaffomycetaceae; Wickerhamomyces.
OX NCBI_TaxID=683960 {ECO:0000313|EMBL:ODQ60014.1, ECO:0000313|Proteomes:UP000094112};
RN [1] {ECO:0000313|EMBL:ODQ60014.1, ECO:0000313|Proteomes:UP000094112}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 58044 / CBS 1984 / NCYC 433 / NRRL Y-366-8
RC {ECO:0000313|Proteomes:UP000094112};
RX PubMed=27535936; DOI=10.1073/pnas.1603941113;
RA Riley R., Haridas S., Wolfe K.H., Lopes M.R., Hittinger C.T., Goeker M.,
RA Salamov A.A., Wisecaver J.H., Long T.M., Calvey C.H., Aerts A.L.,
RA Barry K.W., Choi C., Clum A., Coughlan A.Y., Deshpande S., Douglass A.P.,
RA Hanson S.J., Klenk H.-P., LaButti K.M., Lapidus A., Lindquist E.A.,
RA Lipzen A.M., Meier-Kolthoff J.P., Ohm R.A., Otillar R.P., Pangilinan J.L.,
RA Peng Y., Rokas A., Rosa C.A., Scheuner C., Sibirny A.A., Slot J.C.,
RA Stielow J.B., Sun H., Kurtzman C.P., Blackwell M., Grigoriev I.V.,
RA Jeffries T.W.;
RT "Comparative genomics of biotechnologically important yeasts.";
RL Proc. Natl. Acad. Sci. U.S.A. 113:9882-9887(2016).
CC -!- COFACTOR:
CC Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
CC Evidence={ECO:0000256|ARBA:ARBA00001913};
CC -!- PATHWAY: Protein modification; protein glycosylation.
CC {ECO:0000256|ARBA:ARBA00004922}.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum lumen
CC {ECO:0000256|ARBA:ARBA00004319}.
CC -!- SIMILARITY: Belongs to the glycosyltransferase 8 family.
CC {ECO:0000256|ARBA:ARBA00006351}.
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DR EMBL; KV454210; ODQ60014.1; -; Genomic_DNA.
DR RefSeq; XP_019039221.1; XM_019181679.1.
DR STRING; 683960.A0A1E3P489; -.
DR GeneID; 30198925; -.
DR OrthoDB; 1734at2759; -.
DR UniPathway; UPA00378; -.
DR Proteomes; UP000094112; Unassembled WGS sequence.
DR GO; GO:0005788; C:endoplasmic reticulum lumen; IEA:UniProtKB-SubCell.
DR GO; GO:0003980; F:UDP-glucose:glycoprotein glucosyltransferase activity; IEA:InterPro.
DR GO; GO:0006486; P:protein glycosylation; IEA:UniProtKB-UniPathway.
DR CDD; cd06432; GT8_HUGT1_C_like; 1.
DR InterPro; IPR040497; Glyco_transf_24.
DR InterPro; IPR029044; Nucleotide-diphossugar_trans.
DR InterPro; IPR009448; UDP-g_GGtrans.
DR InterPro; IPR040693; UGGT_TRXL_1.
DR InterPro; IPR040694; UGGT_TRXL_2.
DR InterPro; IPR040692; UGGT_TRXL_3.
DR InterPro; IPR040525; UGGT_TRXL_4.
DR PANTHER; PTHR11226; UDP-GLUCOSE GLYCOPROTEIN:GLUCOSYLTRANSFERASE; 1.
DR PANTHER; PTHR11226:SF0; UDP-GLUCOSE:GLYCOPROTEIN GLUCOSYLTRANSFERASE; 1.
DR Pfam; PF18404; Glyco_transf_24; 1.
DR Pfam; PF18400; Thioredoxin_12; 1.
DR Pfam; PF18401; Thioredoxin_13; 1.
DR Pfam; PF18402; Thioredoxin_14; 2.
DR Pfam; PF18403; Thioredoxin_15; 1.
DR Pfam; PF06427; UDP-g_GGTase; 1.
DR SUPFAM; SSF53448; Nucleotide-diphospho-sugar transferases; 1.
PE 3: Inferred from homology;
KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Reference proteome {ECO:0000313|Proteomes:UP000094112};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:ODQ60014.1}.
FT SIGNAL 1..18
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 19..1430
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5009133646"
FT DOMAIN 30..220
FT /note="UGGT thioredoxin-like"
FT /evidence="ECO:0000259|Pfam:PF18400"
FT DOMAIN 273..405
FT /note="UGGT thioredoxin-like"
FT /evidence="ECO:0000259|Pfam:PF18401"
FT DOMAIN 420..534
FT /note="UGGT thioredoxin-like"
FT /evidence="ECO:0000259|Pfam:PF18402"
FT DOMAIN 558..624
FT /note="UGGT thioredoxin-like"
FT /evidence="ECO:0000259|Pfam:PF18402"
FT DOMAIN 649..821
FT /note="UDP-glucose:glycoprotein glucosyltransferase
FT thioredoxin-like"
FT /evidence="ECO:0000259|Pfam:PF18403"
FT DOMAIN 1125..1392
FT /note="Glucosyltransferase 24 catalytic"
FT /evidence="ECO:0000259|Pfam:PF18404"
FT REGION 1404..1430
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1430 AA; 163942 MW; 878E0853AD422242 CRC64;
MLRSILVTTL LFASTVLGQI DIQLQANWEN PPFTLRLLET ITSENESYYL QALSKISSIS
LDEEDSELQE DLNDEDLYNS LFDLLTPTER SLYNIPLANK YYSPRIITHY KYYNETVLPE
FESKLQKKCG AVPKTWVQFN DVVYCKPDDV FALMTDGGSD ESESLLPFDR IIGDSGPLLV
LYGDVNDSEF KPFISNLYDS AKYGKLRFVW RYVPQNVDQR EQLAGYGVDL TLKRTDYIVI
DDRDAEINQK NKLKQQQVLK DQDTPSSFLD IYQQDIPAVS KEALKDLDLK IASFAVASKN
SSENYENLVK AVQDLPKYSS YLSELEINED LIEQAEFNEK IGLTSDSSAI FINGLPVDDA
DLNVFGLYKT VKRELNFVKQ LNDVGIDSNT AKTVLGKFAL LSISKNRRGS KTRYDIEAGE
NNPVIFFNDI ENDPIYTHLL DDLSVYLERQ QFGQIPLYRG NVHDVVFAIN FGDDDQYKIL
KRLSQAILQR GIPQRIGIIP LVNSEEDAIH ANNIYYLLEN GGLKKVLKYV NKIGTGSPKR
LTDGDFVSKY VDPFVSSFDV QNPSIVVNGV FFNLDDNWPY ALTRQVTEDV NLIATLVYTN
TIKESDSVKE KAFEGAATFR NTIVVPENRA DIQYKAITPQ FQEAMKSSSN YIFEFSNSKR
AKPVQTLTFG GNLGSKIGLQ QLVEILKFAF AANYDMKIRV INNSDEATFI GKIRQALNRS
IDHAIDVIQE IIEEHEFTET DENQGIKDLL KLADIESTKF LLLNGRYIEL KDELLKSDAL
EYLSNYEFEM RLELVGKVIK NHGIPEHGEY HDWFESFSSI LTKTFYIGTD LFTPAPLPRF
DFGAIKKDYA ISFGDQGQSD LHVLLVIDPV EEISQKLLFL IQSIKDLSFV SLDILIQPQK
DLESLPIKRF FRGNYKSGVE FKDGKVFESP FVSFDKAPEK TLFTLDLDVP SSWIVVPKES
ISDLDNVLLD QSGPVTGIYE LENIAVEGNS FDINTREPPT GLSVQIKGSD TNVMTNYGYL
QLKGNPGLWD FEIKQGKSSE IYSLLSIDDF ESEELEKHDK IQFSVLNLDG VRIFPRVMKN
PGKENESLVL SDSSISTQVE KQEEENKPGF LQKLFQKKTK KQADINIFTI ASGHLYERFL
SIMTASVMRH TKHTVKFWLI ENYMSPSFKK FLPHLAKKYG FEYELITYKW PSWLRGQREK
QRTIWGYKIL FLDVLFPQDL DKVIFVDADQ IVRTDLKELV DMDLEGAPYG YTPMGDSREE
MEGFRFWKQG YWAKFLGDEM KYHISALYVV DLKRFREIAA GDMLRQHYQA LSKDPNSLSN
LDQDLPNNLQ TRLKIFSLPQ DWLWCETWCD DESLKTAKTI DLCNNPLTKE PKLDRARRQI
PEWTKYDNEI AALRDQVRKL EHIYEETTES YDESTSTGVP ESENTVHDEL
//
