ID A0A1E3PAT9_WICAA Unreviewed; 763 AA.
AC A0A1E3PAT9;
DT 18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT 18-JAN-2017, sequence version 1.
DT 13-SEP-2023, entry version 25.
DE RecName: Full=Rho-GAP domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=WICANDRAFT_24775 {ECO:0000313|EMBL:ODQ61987.1};
OS Wickerhamomyces anomalus (strain ATCC 58044 / CBS 1984 / NCYC 433 / NRRL
OS Y-366-8) (Yeast) (Hansenula anomala).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Phaffomycetaceae; Wickerhamomyces.
OX NCBI_TaxID=683960 {ECO:0000313|EMBL:ODQ61987.1, ECO:0000313|Proteomes:UP000094112};
RN [1] {ECO:0000313|EMBL:ODQ61987.1, ECO:0000313|Proteomes:UP000094112}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 58044 / CBS 1984 / NCYC 433 / NRRL Y-366-8
RC {ECO:0000313|Proteomes:UP000094112};
RX PubMed=27535936; DOI=10.1073/pnas.1603941113;
RA Riley R., Haridas S., Wolfe K.H., Lopes M.R., Hittinger C.T., Goeker M.,
RA Salamov A.A., Wisecaver J.H., Long T.M., Calvey C.H., Aerts A.L.,
RA Barry K.W., Choi C., Clum A., Coughlan A.Y., Deshpande S., Douglass A.P.,
RA Hanson S.J., Klenk H.-P., LaButti K.M., Lapidus A., Lindquist E.A.,
RA Lipzen A.M., Meier-Kolthoff J.P., Ohm R.A., Otillar R.P., Pangilinan J.L.,
RA Peng Y., Rokas A., Rosa C.A., Scheuner C., Sibirny A.A., Slot J.C.,
RA Stielow J.B., Sun H., Kurtzman C.P., Blackwell M., Grigoriev I.V.,
RA Jeffries T.W.;
RT "Comparative genomics of biotechnologically important yeasts.";
RL Proc. Natl. Acad. Sci. U.S.A. 113:9882-9887(2016).
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DR EMBL; KV454208; ODQ61987.1; -; Genomic_DNA.
DR RefSeq; XP_019041194.1; XM_019181056.1.
DR AlphaFoldDB; A0A1E3PAT9; -.
DR STRING; 683960.A0A1E3PAT9; -.
DR GeneID; 30198302; -.
DR OrthoDB; 1328399at2759; -.
DR Proteomes; UP000094112; Unassembled WGS sequence.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProt.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR CDD; cd04399; RhoGAP_fRGD2; 1.
DR Gene3D; 1.20.1270.60; Arfaptin homology (AH) domain/BAR domain; 2.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR027267; AH/BAR_dom_sf.
DR InterPro; IPR000591; DEP_dom.
DR InterPro; IPR031160; F_BAR.
DR InterPro; IPR001060; FCH_dom.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR23065; PROLINE-SERINE-THREONINE PHOSPHATASE INTERACTING PROTEIN 1; 1.
DR PANTHER; PTHR23065:SF17; RHO-GTPASE-ACTIVATING PROTEIN RGD2; 1.
DR Pfam; PF00610; DEP; 1.
DR Pfam; PF00611; FCH; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR SMART; SM00049; DEP; 1.
DR SMART; SM00055; FCH; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SUPFAM; SSF103657; BAR/IMD domain-like; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS50186; DEP; 1.
DR PROSITE; PS51741; F_BAR; 1.
DR PROSITE; PS50238; RHOGAP; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|PROSITE-ProRule:PRU01077};
KW Reference proteome {ECO:0000313|Proteomes:UP000094112}.
FT DOMAIN 2..426
FT /note="F-BAR"
FT /evidence="ECO:0000259|PROSITE:PS51741"
FT DOMAIN 233..301
FT /note="DEP"
FT /evidence="ECO:0000259|PROSITE:PS50186"
FT DOMAIN 460..670
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT REGION 170..192
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 698..763
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 699..723
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 724..751
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 763 AA; 86800 MW; DED601DF935F6CA0 CRC64;
MPSFADSFWT PNYSSGIEVL FTKLNQGCIE NDEFINLFTS RMDYEFDYGK KLSALPDIHS
PMKGGFDKDD GASLKNAFKG LALEMGNEGD SHLQIALNIK EMVIDPFSKW SQEHKQRIDY
SEKILKSSLK VYKNKLKAVE KIQKKYFNKC RTLESIKSGM TEEEITKELN SIDLTDSQEQ
KGKSNPSDAD GEEYEPLVVL GGVEYGKIGL KELIRSMLTE VPQGSFKVAI LGVYEHVSTG
SSIVSFLQQQ LGITNIDKCE RFGKDLITNG FIRHVNGVGS NFVNSSTFQY QWKSTAFQIA
DLPIKKNEAD DDDENLNNRK VSNYIDELKN AISYEETSLK KVDNDVKELD AAYKIEVAKL
DKIRCDLEEL IVDHLSFMEK CELDRLRALK KVLLDFSASI SNKLSNIKAI IDKIMIYEET
INPTGDLMFL LQNYRTGSFV PNVVLYDNYY DSFKDQIFGV DLETRCKNDN KTVPVIISSI
LSYMDNIYPE LPNDDVRTKI WLIPVRLQST HALRSEIEKL GSTGLTPEFF KNFEPEVIAS
VLKLYLLELP DSVVPNGLYD LIRSIYNQYG SESESKERIN GITNVLKNLD RSNLSTLNAI
CTHFTRLIKI LLENKNENES NGLASSFQNG ISQEFSNCIL RPRYQNNLSL SDKHSFRFFH
DLLEHKAEIF KNLKPTGSIK KNKSVLAGVE ERITRSEQLS RQSSKLQSRL QQAVITGSRR
VSNEAKSNES DHVRNLTPQN DNEKENNNHS EEQSNAENPI VIE
//
