ID A0A1E3PI11_9ASCO Unreviewed; 824 AA.
AC A0A1E3PI11;
DT 18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT 18-JAN-2017, sequence version 1.
DT 03-MAY-2023, entry version 16.
DE RecName: Full=Probable vacuolar protein sorting-associated protein 16 homolog {ECO:0000256|PIRNR:PIRNR007949};
GN ORFNames=NADFUDRAFT_51665 {ECO:0000313|EMBL:ODQ65066.1};
OS Nadsonia fulvescens var. elongata DSM 6958.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetales incertae sedis; Nadsonia.
OX NCBI_TaxID=857566 {ECO:0000313|EMBL:ODQ65066.1, ECO:0000313|Proteomes:UP000095009};
RN [1] {ECO:0000313|EMBL:ODQ65066.1, ECO:0000313|Proteomes:UP000095009}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 6958 {ECO:0000313|EMBL:ODQ65066.1,
RC ECO:0000313|Proteomes:UP000095009};
RX PubMed=27535936; DOI=10.1073/pnas.1603941113;
RA Riley R., Haridas S., Wolfe K.H., Lopes M.R., Hittinger C.T., Goeker M.,
RA Salamov A.A., Wisecaver J.H., Long T.M., Calvey C.H., Aerts A.L.,
RA Barry K.W., Choi C., Clum A., Coughlan A.Y., Deshpande S., Douglass A.P.,
RA Hanson S.J., Klenk H.-P., LaButti K.M., Lapidus A., Lindquist E.A.,
RA Lipzen A.M., Meier-Kolthoff J.P., Ohm R.A., Otillar R.P., Pangilinan J.L.,
RA Peng Y., Rokas A., Rosa C.A., Scheuner C., Sibirny A.A., Slot J.C.,
RA Stielow J.B., Sun H., Kurtzman C.P., Blackwell M., Grigoriev I.V.,
RA Jeffries T.W.;
RT "Comparative genomics of biotechnologically important yeasts.";
RL Proc. Natl. Acad. Sci. U.S.A. 113:9882-9887(2016).
CC -!- FUNCTION: Essential for vacuolar protein sorting. Required for vacuole
CC biogenesis, stability and to maintain vacuole morphology.
CC {ECO:0000256|PIRNR:PIRNR007949}.
CC -!- SIMILARITY: Belongs to the VPS16 family.
CC {ECO:0000256|ARBA:ARBA00009250, ECO:0000256|PIRNR:PIRNR007949}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; KV454410; ODQ65066.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1E3PI11; -.
DR STRING; 857566.A0A1E3PI11; -.
DR OrthoDB; 1110811at2759; -.
DR Proteomes; UP000095009; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR GO; GO:0012505; C:endomembrane system; IEA:UniProt.
DR GO; GO:0043231; C:intracellular membrane-bounded organelle; IEA:UniProt.
DR GO; GO:0032991; C:protein-containing complex; IEA:UniProt.
DR GO; GO:0006886; P:intracellular protein transport; IEA:UniProtKB-UniRule.
DR GO; GO:0007033; P:vacuole organization; IEA:InterPro.
DR Gene3D; 1.10.150.780; Vps16, C-terminal region; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR016534; VPS16.
DR InterPro; IPR006925; Vps16_C.
DR InterPro; IPR038132; Vps16_C_sf.
DR InterPro; IPR006926; Vps16_N.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR PANTHER; PTHR12811; VACUOLAR PROTEIN SORTING VPS16; 1.
DR PANTHER; PTHR12811:SF0; VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 16 HOMOLOG; 1.
DR Pfam; PF04840; Vps16_C; 1.
DR Pfam; PF04841; Vps16_N; 1.
DR PIRSF; PIRSF007949; VPS16; 1.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
PE 3: Inferred from homology;
KW Protein transport {ECO:0000256|PIRNR:PIRNR007949};
KW Reference proteome {ECO:0000313|Proteomes:UP000095009};
KW Transport {ECO:0000256|PIRNR:PIRNR007949}.
FT DOMAIN 5..409
FT /note="Vps16 N-terminal"
FT /evidence="ECO:0000259|Pfam:PF04841"
FT DOMAIN 503..806
FT /note="Vps16 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF04840"
SQ SEQUENCE 824 AA; 94058 MW; 8BFE7A8ABBEE1888 CRC64;
MPPNPILSWE RLEDNFYRSL DTYTMIWEGI NLDDYDVACS PFGGAIAMTR NELKLREYKG
GESRQTGISI FSGVGKLMKR LPWDSGRIKG LGWTNQEHII AVSEEGITRH YYDFQGNFKQ
FSLGKEAEEH NVVECKFWEN GFVALLSNKR FIIVSNYQRP NPRFLAKMED VDEDITSWAI
RPPTSIYNQS AGVLVGLATK VFILDTATCQ QVNFDKTINL MMVSPNGQLV VCQCSDGSLD
IVTTDFQNTI STYNDAERTG LPSSISWCGN DAIGLVWEDE LTLVGFNSET LTMYYDSSVI
LFPELDGLRI FSSERHEFFA KVPSVVVDIF KIGSTTPGAI LLDCVDHLER RSPKADENLQ
IIGPHLIDAV DNCIQAAKYE FDQYWQKRLL KAASLGKSSL DLYNSDEFVT ACDNIRVLNA
VRQFDVGMMI SYDQFLQLTP ERLVERLLLR QMHFLSLKLC MYLHVPSDKI YIDWACSKIK
LSNEDDDTLC EIIVGKLAKK QGVSYVDIAK TAYDEGRAKL ATILTSYEPR AGRQVPLLIS
MGEDGIALTK AVESGDTDLI IYVFHHLRRK LSLAQFFRLL SDKPMANRVF EAIIRSENIQ
LLKDFYYQDD KRVPSANLLF IEAYHEPEMD TKFEQLEQAR KIFQDIKDYS FEAKMVEEST
KLLHVQQLLE SDYEESSFVG LSLTGTIFEL LKMSQNVRAL KLKNDFKVPD KRFWWSKVKA
LVSRRDWSEL MEFAKTKRSP IGYEPFYQTC LQAGSKSAAA NYVSMCTNLD YTERVKMYIE
VNEPKLAAEE AFKFKDITLL KSLVASASAG LASEIERYLK ILKR
//
