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Database: UniProt
Entry: A0A1E3PNB5_9ASCO
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ID   A0A1E3PNB5_9ASCO        Unreviewed;      1653 AA.
AC   A0A1E3PNB5;
DT   18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT   18-JAN-2017, sequence version 1.
DT   08-MAY-2019, entry version 12.
DE   RecName: Full=DNA polymerase {ECO:0000256|RuleBase:RU000442};
DE            EC=2.7.7.7 {ECO:0000256|RuleBase:RU000442};
DE   Flags: Fragment;
GN   ORFNames=NADFUDRAFT_8577 {ECO:0000313|EMBL:ODQ66790.1};
OS   Nadsonia fulvescens var. elongata DSM 6958.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina;
OC   Saccharomycetes; Saccharomycetales; Saccharomycetales incertae sedis;
OC   Nadsonia.
OX   NCBI_TaxID=857566 {ECO:0000313|EMBL:ODQ66790.1, ECO:0000313|Proteomes:UP000095009};
RN   [1] {ECO:0000313|EMBL:ODQ66790.1, ECO:0000313|Proteomes:UP000095009}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 6958 {ECO:0000313|EMBL:ODQ66790.1,
RC   ECO:0000313|Proteomes:UP000095009};
RX   PubMed=27535936; DOI=10.1073/pnas.1603941113;
RA   Riley R., Haridas S., Wolfe K.H., Lopes M.R., Hittinger C.T.,
RA   Goker M., Salamov A.A., Wisecaver J.H., Long T.M., Calvey C.H.,
RA   Aerts A.L., Barry K.W., Choi C., Clum A., Coughlan A.Y., Deshpande S.,
RA   Douglass A.P., Hanson S.J., Klenk H.P., LaButti K.M., Lapidus A.,
RA   Lindquist E.A., Lipzen A.M., Meier-Kolthoff J.P., Ohm R.A.,
RA   Otillar R.P., Pangilinan J.L., Peng Y., Rokas A., Rosa C.A.,
RA   Scheuner C., Sibirny A.A., Slot J.C., Stielow J.B., Sun H.,
RA   Kurtzman C.P., Blackwell M., Grigoriev I.V., Jeffries T.W.;
RT   "Comparative genomics of biotechnologically important yeasts.";
RL   Proc. Natl. Acad. Sci. U.S.A. 113:9882-9887(2016).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC         diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-
CC         COMP:11130, Rhea:RHEA-COMP:11131, ChEBI:CHEBI:33019,
CC         ChEBI:CHEBI:61560, ChEBI:CHEBI:83828; EC=2.7.7.7;
CC         Evidence={ECO:0000256|RuleBase:RU000442};
CC   -!- COFACTOR:
CC       Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC         Evidence={ECO:0000256|RuleBase:RU000442};
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|RuleBase:RU000442}.
CC   -!- SIMILARITY: Belongs to the DNA polymerase type-B family.
CC       {ECO:0000256|RuleBase:RU000442}.
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DR   EMBL; KV454408; ODQ66790.1; -; Genomic_DNA.
DR   EnsemblFungi; ODQ66790; ODQ66790; NADFUDRAFT_8577.
DR   OrthoDB; 20210at2759; -.
DR   Proteomes; UP000095009; Unassembled WGS sequence.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0016035; C:zeta DNA polymerase complex; IEA:InterPro.
DR   GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0000166; F:nucleotide binding; IEA:InterPro.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   GO; GO:0019985; P:translesion synthesis; IEA:InterPro.
DR   Gene3D; 1.10.132.60; -; 1.
DR   Gene3D; 3.30.420.10; -; 1.
DR   Gene3D; 3.90.1600.10; -; 1.
DR   InterPro; IPR006172; DNA-dir_DNA_pol_B.
DR   InterPro; IPR017964; DNA-dir_DNA_pol_B_CS.
DR   InterPro; IPR006133; DNA-dir_DNA_pol_B_exonuc.
DR   InterPro; IPR006134; DNA-dir_DNA_pol_B_multi_dom.
DR   InterPro; IPR042087; DNA_pol_B_C.
DR   InterPro; IPR023211; DNA_pol_palm_dom_sf.
DR   InterPro; IPR030559; PolZ_Rev3.
DR   InterPro; IPR012337; RNaseH-like_sf.
DR   InterPro; IPR036397; RNaseH_sf.
DR   InterPro; IPR025687; Znf-C4pol.
DR   PANTHER; PTHR45812; PTHR45812; 1.
DR   Pfam; PF00136; DNA_pol_B; 1.
DR   Pfam; PF03104; DNA_pol_B_exo1; 2.
DR   Pfam; PF14260; zf-C4pol; 1.
DR   PRINTS; PR00106; DNAPOLB.
DR   SMART; SM00486; POLBc; 1.
DR   SUPFAM; SSF53098; SSF53098; 1.
DR   PROSITE; PS00116; DNA_POLYMERASE_B; 1.
PE   3: Inferred from homology;
KW   4Fe-4S {ECO:0000256|RuleBase:RU000442};
KW   Complete proteome {ECO:0000313|Proteomes:UP000095009};
KW   DNA replication {ECO:0000256|RuleBase:RU000442};
KW   DNA-binding {ECO:0000256|RuleBase:RU000442};
KW   DNA-directed DNA polymerase {ECO:0000256|RuleBase:RU000442};
KW   Iron {ECO:0000256|RuleBase:RU000442};
KW   Iron-sulfur {ECO:0000256|RuleBase:RU000442};
KW   Metal-binding {ECO:0000256|RuleBase:RU000442};
KW   Nucleotidyltransferase {ECO:0000256|RuleBase:RU000442};
KW   Nucleus {ECO:0000256|RuleBase:RU000442};
KW   Reference proteome {ECO:0000313|Proteomes:UP000095009};
KW   Transferase {ECO:0000256|RuleBase:RU000442};
KW   Zinc {ECO:0000256|RuleBase:RU000442};
KW   Zinc-finger {ECO:0000256|RuleBase:RU000442}.
FT   DOMAIN       45    187       DNA_pol_B_exo1. {ECO:0000259|Pfam:
FT                                PF03104}.
FT   DOMAIN      808    998       DNA_pol_B_exo1. {ECO:0000259|Pfam:
FT                                PF03104}.
FT   DOMAIN     1065   1511       DNA_pol_B. {ECO:0000259|Pfam:PF00136}.
FT   DOMAIN     1555   1632       zf-C4pol. {ECO:0000259|Pfam:PF14260}.
FT   NON_TER       1      1       {ECO:0000313|EMBL:ODQ66790.1}.
FT   NON_TER    1653   1653       {ECO:0000313|EMBL:ODQ66790.1}.
SQ   SEQUENCE   1653 AA;  188508 MW;  085BF8FED3434E47 CRC64;
     FRFQINNTDF YMSEPTILDK STINITNPPT NFTSVPIIRL FGRADDGLSV MAHIHGVYPY
     LFIEYKGSLI PDDVDRGIAY LFRAINEALT IAYKRNPEGS ASKFVANIIL CKATPFYGFH
     VGWSYYLKIY MLNPSHINKL SDLLRNGNVT GTPIQPYEAH IPYLLQFFAD FNLFGCGWMN
     LSKAYFRQPL PTDDQGTANF NWHGETSSFS LSEYDIHSIA SPDLLLDSDA FPKNSFVPLE
     IDVLAQFIEN RHQIEPRSLH HNFIERDHPI SPDTKFVNSV KELWDEDRAR RQQIDPCSAY
     SPPATFDDVD LIRDYSTAKW LSEDEMRFQL RQAANESKRA YQGILPQFEH FIHPKPYNGL
     VKSVLNVVDA MFTEVTDQLF RNDRQGTVNI EKSQNIYDVL GLNAETVNRK AGSSEQNDQN
     CERSEGDTIC VKDILGSKMC IYEIQMDIDD AFESPVLTPQ TLRDREGNND IDKNELTFDQ
     TELKDGFNDI IKGTQEIDQN KPVRGRMSPP FLKSILKNSP AVKGILNIST PAPVINANQK
     NPNTPTKISS FQMPVSSANR SISFNDTPQY LPLSSKWQNM STPLNKRNIS FSEMSFETSL
     SRIQKRRIPY ISTSSSVPET PEASLINAIS TEFDITLPSI ILRAGKKPPS IQEIVSTLGV
     LGLEETHYQE PFYSEKSDIS SRPLAFAGVE HHVLGNSVPY LEPFIFEAGI SNTIDNKFGL
     IDKAGAHSDT SKFIWQYIEI PPSYEEVIQW LKSANTEAEV ASKKPSWKSL LSSQIDVKFT
     PNKYGFKYAS QRKRRFVNRK GLKPLLMTAL GIEIHVNTRG HKQPDPKYDA IACIFWKEYV
     GNQSQERASG DNTSDPEDIL EDMDSTPVQE GIILLSSDYE RTKRLKSLVN WDVQVERSEN
     DMIIALIDLV RDLDPDILTG FEIHGSSWGY IIDRGKTHFE FEMCNELSRI DGNSRHKIND
     RWGFTHASAI HITGRHFINT WRVLRSELNL LQYTIENVVY HVLHVRIPKY SHHTLSEWYR
     NGNNTQITAF FQYYIDRVKY NMLLIEHQEI ITRTCEYARL IGIDFYSVLS RGSQYKVESI
     MIRIAKAENF ILVSPSRKQV AQQNALECLP LVMEPTSKFY SSPMLVLDFQ SLYPSCVIAY
     NYCYSTCLGR VQGWKGTSKM GFTNLDLPPG LLDLLKEDIN ISPNGIMFVK PNVRKSLLSK
     MLKELLDTRV MIKSAMKIDK SDIGYQKLQH NRQLSLKLIA NVTYGYTSAT FSGRMPCSDI
     ADAIVQTGRE TLERAINIIQ KNEYWNAEVV YGDTDSLFVY LPGRTKDEAF RIGQEISDTV
     TKNNPPPIKL KFEKVYLPCV LLAKKRYVGY SYENPNEKVP LFDAKGIETV RRDGTPAQQK
     ILEQVLRILF NTTDLSKIKS YLYSQWLKII KGKVSIQDFC FAKEVKLGSY KTGGTLPPGA
     HISAKKLAND ERDMPQYRER VPYVIVTGSP GQRLVDRAVP PEELMRNPQL RLDAEYYIIK
     NLIPPLERVL NILGASAKQW YKDMPRIIRY QSTRANNRSL FTDTTLSGFV KSGTCRICQN
     EKACETKVEG VGHDCLLPIN LPRSVYTLQS RIKEREKEFA ELNIICRNCS GFPPGTRTID
     CVSGECPTFY SRVKSYAKLD NCYNTDLKIV KDL
//
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