ID A0A1E3PQS8_9ASCO Unreviewed; 960 AA.
AC A0A1E3PQS8;
DT 18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT 18-JAN-2017, sequence version 1.
DT 24-JAN-2024, entry version 19.
DE SubName: Full=DNA mismatch repair protein msh-2 {ECO:0000313|EMBL:ODQ67660.1};
GN ORFNames=NADFUDRAFT_69419 {ECO:0000313|EMBL:ODQ67660.1};
OS Nadsonia fulvescens var. elongata DSM 6958.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetales incertae sedis; Nadsonia.
OX NCBI_TaxID=857566 {ECO:0000313|EMBL:ODQ67660.1, ECO:0000313|Proteomes:UP000095009};
RN [1] {ECO:0000313|EMBL:ODQ67660.1, ECO:0000313|Proteomes:UP000095009}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 6958 {ECO:0000313|EMBL:ODQ67660.1,
RC ECO:0000313|Proteomes:UP000095009};
RX PubMed=27535936; DOI=10.1073/pnas.1603941113;
RA Riley R., Haridas S., Wolfe K.H., Lopes M.R., Hittinger C.T., Goeker M.,
RA Salamov A.A., Wisecaver J.H., Long T.M., Calvey C.H., Aerts A.L.,
RA Barry K.W., Choi C., Clum A., Coughlan A.Y., Deshpande S., Douglass A.P.,
RA Hanson S.J., Klenk H.-P., LaButti K.M., Lapidus A., Lindquist E.A.,
RA Lipzen A.M., Meier-Kolthoff J.P., Ohm R.A., Otillar R.P., Pangilinan J.L.,
RA Peng Y., Rokas A., Rosa C.A., Scheuner C., Sibirny A.A., Slot J.C.,
RA Stielow J.B., Sun H., Kurtzman C.P., Blackwell M., Grigoriev I.V.,
RA Jeffries T.W.;
RT "Comparative genomics of biotechnologically important yeasts.";
RL Proc. Natl. Acad. Sci. U.S.A. 113:9882-9887(2016).
CC -!- FUNCTION: Component of the post-replicative DNA mismatch repair system
CC (MMR). {ECO:0000256|RuleBase:RU003756}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC {ECO:0000256|ARBA:ARBA00006271, ECO:0000256|RuleBase:RU003756}.
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DR EMBL; KV454407; ODQ67660.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1E3PQS8; -.
DR STRING; 857566.A0A1E3PQS8; -.
DR OrthoDB; 168255at2759; -.
DR Proteomes; UP000095009; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:InterPro.
DR CDD; cd03285; ABC_MSH2_euk; 1.
DR Gene3D; 1.10.1420.10; -; 2.
DR Gene3D; 3.40.1170.10; DNA repair protein MutS, domain I; 1.
DR Gene3D; 3.30.420.110; MutS, connector domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR011184; DNA_mismatch_repair_Msh2.
DR InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR InterPro; IPR032642; Msh2_ATP-bd.
DR InterPro; IPR036678; MutS_con_dom_sf.
DR InterPro; IPR045076; MutS_family.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR11361:SF35; DNA MISMATCH REPAIR PROTEIN MSH2; 1.
DR PANTHER; PTHR11361; DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER; 1.
DR Pfam; PF01624; MutS_I; 1.
DR Pfam; PF05188; MutS_II; 1.
DR Pfam; PF05192; MutS_III; 1.
DR Pfam; PF05190; MutS_IV; 1.
DR Pfam; PF00488; MutS_V; 1.
DR PIRSF; PIRSF005813; MSH2; 1.
DR SMART; SM00534; MUTSac; 1.
DR SMART; SM00533; MUTSd; 1.
DR SUPFAM; SSF48334; DNA repair protein MutS, domain III; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|RuleBase:RU003756};
KW DNA repair {ECO:0000256|RuleBase:RU003756};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|RuleBase:RU003756};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU003756}; Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000095009}.
FT DOMAIN 745..761
FT /note="DNA mismatch repair proteins mutS family"
FT /evidence="ECO:0000259|PROSITE:PS00486"
FT COILED 473..500
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 960 AA; 106579 MW; 2BB6B1A19307EF7E CRC64;
MAPSTNPDLN LDKSDEVGFV SFFKSLPVSE HVTTSSVIRI FERADFYTAH GQDAFFIADH
VYRTTSVIKY LGNGSNAIPS VTMSTAVFRG FLKEALVDLG LKVDIYSSAV GGRSWKITRQ
ASPGNIQAVE DLIAGNIDIN PVVIATKVQV KNDQRTVGVC FIDTNMHQIG ISEFIDNEVF
SNLESLIIQL GVKECILPSF DSSKDFDLNK IASLMERCDI VISERPAKDF HTRDIEQDLT
RLLSPVSQDD DQEISVAVLP QMELTVALAS TASLIKYLSL MNEVSNHGLY QLVQHDLGQY
MRLDSSALRA LNLMPSARDG SSKTNSLFGL LNKCKTAAGT RLLGQWLKQP LMDVAEIEKR
HVLVEAMIAD SGVRQSLQED LFKVVPDLNK LTRKFLRGAA KLEDVVRVYQ MIIRLPDFVN
LLSSISEGPH KAAVEEIYIN RLNVHLDNLL KLQELVETTV DLEALDNHEF IIKADFDEKL
QDIKGRLDQL KESIALAHLE TSEDLGMEAD KKLKLEHHHV FGWCMRLTRT DAGCLRSKSG
YTELSTQKAG VYFTSRALKE ASIEFEDLNN EYSLTQANLV KEVVSIASTY CPLLEKISLV
LSHLDVIVSF AHVSVFAPIE YVRPKMSARG SGNTILKEAR HPCMEAQDDI TFIPNDVNLI
RGSSEFLIIT GPNMGGKSTF IRQIGVIALM AQAGCFVPCT EAELSIYDSV LARVGAGDSQ
LKGVSTFMAE MLETATILKS ATRESLIVID ELGRGTSTYD GFGLAWAISE HIIENIGCSS
MFATHFHELT ALSKTHPAVS NLHVAAHIED TEDASTDITL LYKVEEGISD QSFGIHVAEV
VNFPSKVVLM AKRKAAELED YGGMELDSAH AKKKLHKYTN EEIKSGNELL RSVLKKWADS
VDIIAESPDV IVQKLNDVME SDEFKSQIDS YLKRSTSQLG EHEEQREQWI KSRYLDDVSV
//
