ID A0A1E3PRE0_9ASCO Unreviewed; 4944 AA.
AC A0A1E3PRE0;
DT 18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT 18-JAN-2017, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE RecName: Full=Midasin {ECO:0000256|ARBA:ARBA00017143};
DE Flags: Fragment;
GN ORFNames=NADFUDRAFT_13250 {ECO:0000313|EMBL:ODQ67900.1};
OS Nadsonia fulvescens var. elongata DSM 6958.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetales incertae sedis; Nadsonia.
OX NCBI_TaxID=857566 {ECO:0000313|EMBL:ODQ67900.1, ECO:0000313|Proteomes:UP000095009};
RN [1] {ECO:0000313|EMBL:ODQ67900.1, ECO:0000313|Proteomes:UP000095009}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 6958 {ECO:0000313|EMBL:ODQ67900.1,
RC ECO:0000313|Proteomes:UP000095009};
RX PubMed=27535936; DOI=10.1073/pnas.1603941113;
RA Riley R., Haridas S., Wolfe K.H., Lopes M.R., Hittinger C.T., Goeker M.,
RA Salamov A.A., Wisecaver J.H., Long T.M., Calvey C.H., Aerts A.L.,
RA Barry K.W., Choi C., Clum A., Coughlan A.Y., Deshpande S., Douglass A.P.,
RA Hanson S.J., Klenk H.-P., LaButti K.M., Lapidus A., Lindquist E.A.,
RA Lipzen A.M., Meier-Kolthoff J.P., Ohm R.A., Otillar R.P., Pangilinan J.L.,
RA Peng Y., Rokas A., Rosa C.A., Scheuner C., Sibirny A.A., Slot J.C.,
RA Stielow J.B., Sun H., Kurtzman C.P., Blackwell M., Grigoriev I.V.,
RA Jeffries T.W.;
RT "Comparative genomics of biotechnologically important yeasts.";
RL Proc. Natl. Acad. Sci. U.S.A. 113:9882-9887(2016).
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus
CC {ECO:0000256|ARBA:ARBA00004604}. Nucleus, nucleoplasm
CC {ECO:0000256|ARBA:ARBA00004642}.
CC -!- SIMILARITY: Belongs to the midasin family.
CC {ECO:0000256|ARBA:ARBA00007188}.
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DR EMBL; KV454406; ODQ67900.1; -; Genomic_DNA.
DR STRING; 857566.A0A1E3PRE0; -.
DR OrthoDB; 1221059at2759; -.
DR Proteomes; UP000095009; Unassembled WGS sequence.
DR GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR GO; GO:0005654; C:nucleoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR CDD; cd00009; AAA; 2.
DR CDD; cd01460; vWA_midasin; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 6.
DR Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR040848; AAA_lid_7.
DR InterPro; IPR011704; ATPase_dyneun-rel_AAA.
DR InterPro; IPR048617; MDN1_AAA_lid_4.
DR InterPro; IPR012099; Midasin.
DR InterPro; IPR041190; Midasin_AAA_lid_5.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR025662; Sigma_54_int_dom_ATP-bd_1.
DR InterPro; IPR002035; VWF_A.
DR InterPro; IPR036465; vWFA_dom_sf.
DR PANTHER; PTHR48103:SF2; MIDASIN; 1.
DR PANTHER; PTHR48103; MIDASIN-RELATED; 1.
DR Pfam; PF07728; AAA_5; 8.
DR Pfam; PF17865; AAA_lid_5; 1.
DR Pfam; PF17867; AAA_lid_7; 3.
DR Pfam; PF21108; MDN1_4th; 1.
DR PIRSF; PIRSF010340; Midasin; 1.
DR SMART; SM00382; AAA; 6.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 6.
DR SUPFAM; SSF53300; vWA-like; 1.
DR PROSITE; PS00675; SIGMA54_INTERACT_1; 1.
DR PROSITE; PS50234; VWFA; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Chaperone {ECO:0000256|ARBA:ARBA00023186};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000095009}.
FT DOMAIN 4740..4935
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT REGION 4078..4617
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4131..4184
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4185..4212
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4226..4241
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4242..4262
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4274..4389
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4390..4404
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4420..4439
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4443..4465
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4482..4540
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4541..4558
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4571..4588
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:ODQ67900.1"
FT NON_TER 4944
FT /evidence="ECO:0000313|EMBL:ODQ67900.1"
SQ SEQUENCE 4944 AA; 557012 MW; 1103CB527E45EBC6 CRC64;
DINKLAVFAL NEKYTLMVIA SYQTIFPDII SRWISNPEIE KSFALKFRKN IEYVPGTIIL
SSLARIVPFV PESIPLIQHF IIQNNFLTSL HTYGSVTKQT ILVSVARLIS DKRDDFSSFF
EPTILTRCLS DETPVIKYLT LQILSLHLQA SEDSRFKFID SHIGMEKSIL GDYEGSEEVD
YFFFPLLEAK RIANGFDFLA DNSLASKESN NTDISITITR DQLSPLTANI GNVLVPRLTG
PASFESELVP TESSLTCISY LAESLRSGEP ILLTGPAGSG KTFFINEIAK CLSKEEEMVR
IHLGDQTDAK LLIGTYATGQ KPGSFEWRPG VLTMAVREGR WVLIEDIDKA PTDVLSVLLP
LLEKKELLIP SRGEVIKAKR GFQIIGTMRT TINTKTKTPI VPDLIGMRMW KQVSVGEPTS
DELKQIIKTR FPIIANLTSS FVDTYYTTKD LYVDPKFISV NKSSLGRQLA TRDLVKWARR
VVSMLSHNDV VSSSQELPAE IYDNIFAEAI DCFASFIPST EAREMLAQSI GQSLDVSSAR
VGLFLKKHVP SLDDNETFFS VGRAYLEKSG AISKLKAHLT QKKQNQFANT NHSLRLMEQI
GVSVTMAEPV LLVGETGTGK TTVVQHLANA LHKNLTVINV SQQTESGDLI GGYKPIDAKL
IAVPLKEEFD TLFELTFSTK KNEKFSNLLI KCFAKGHWGN TVKLWKEAVK MAHEVLGGDD
SDDESASKKR RKIHGTQRQL VLEQWNNFKA RVENFEIQVK QVEKSFVFSF VEGSLVKAVR
NGDWVLLDEI NLAAPDTLES ISDLLAENGQ GSIILSEKGD AEAVKAHPNF RLFACMNPAT
DIGKRDLPTG LRSRFTELYV TSPDEDIADL LAIIDKYIGR LSIGDEWVGN DVAQLYLEAK
KLAEAHKIVD GANQRPHFSI RTLSRTLTYV SGITHVYGLR RSLYEGFCMS FLTLLDSASE
EMLHPIIKRY TIDKLKNARS VINQIPPAPQ DGNQYVQFKH YWLQCGINQP EDQPHYIITP
FVEKNMANLI RATAGRRFPV LIQGPTSSGK TSMVNYLAKK TGNKFVRINN HEHTDLQEYL
GSYVSDANGK LYFQEGILVE ALRKGYWIVL DELNLAPTDV LEALNRLLDD NRELLIPETQ
EVVRPHPHFM LFATQNPPGL YGGRKVLSRA FRNRFLELHF DDIPENELET IIRERCQIAP
TYSKKIVDVY RQLSVQRQSS RIFEQKNSFA TLRDLFRWAG REAVGYEQLA ANGYMLLAER
VRRPEEKIIV KEAIEKIMKV KLDPKKIYAS LEESFMSEPN EHVIWTKAMR KLAVLVNEAL
KNNEPILLVG ETGCGKTTIC QVLAEQLKKE LNIVNAHQNT ETGDIIGAQR PVRNRSELQE
SLAKVLTQAL VSVNIEPSSD LQELGQAFDI IQDKSSILPE VIEQINDLRA KLKVLFEWAD
GSLIKTLKSG DFFLLDEISL ADDSVLERLN SVLEPERTLL LAEKGTNESN ITAKDGFQFF
ATMNPGGDYG KKELSPALRN RFTEIWVPSM DDFEDVLLIV RSKLNESLQL LASSIVKFSE
WFAKTYGAGD ATSGVISLRD ILAWVGFSNS ISKSGDNSVA LLHGACMVFI DSLGTNNTAA
LAEIPERLKQ EKIKCVQSLS EFSKLELLSF YSEKYEVSLS EEYLSCGPFT LQRIDTTTTD
ISFNMQAPTT AANAMRVVRG MQVNKPILLE GSPGVGKTSL ITALAAAVGR PLTRINLSEQ
TDLMDLFGSD SPSESGKAGE FVWRDAAFLR AMQKGEWVLL DEMNLASQSV LEGLNACLDH
RSETYIPELD KTFKCHPGFT VFAAQNPQYQ GGGRKGLPKS FVNRFTVVYI DVLSANDLKM
IGIHLYPSVG EETVSKMIEF VSLLNNEVAI KRSFGHFGSP WEFNMRDTMR WLQLVSQDSG
LDGNRYPSEF LEIIFKDRFR TPKDRELVDN LYKSVFNELP KRDRFVQIGR DYIQAGHSAL
VKSSLNEPYY GESLSSLQCN SGLFETMLTC IQKAWPLILV GPSNSGKTSS IRFLAKAVGA
RLEEFSMNSD IDSMDIVGGF EQVDLTHKAS ALWGQLQVIC LHLTTQLLTT TRETQEQLSF
ALELFELASN VDETTGEILE DLITLLAKKP VFGNEYDLRL QNVFERVTLL NAQYKAVQTV
KFEWFDGILV KAVEEGFWLV LDNANLCSPS VLDRLNSLLE HNGSLIVNEC ALSDGRPRVI
KPHPKFRLFL TVDPKYGELS RAMRNRGTEI FVDDLQIRSS DLDKGLLKLN KKVSVVSDLS
TLAISSKNRT PVVSVLDPTE STMRLFALLD FCLSQGNEDN LESIIGSLLS VLPTKIFNII
TRWASTLAHS DIFTSDIRIA SGAVTEKFTF LAQTPFWNKL REIYSITFNN LKICNSIQCF
SEFEKAINIE TNVYLNDVLL RSLQIDSKAI GSIIDLLLDL WKTKSTLLKV TNNSLRLKPS
EMTYLEKSAV VSSGKAMKNP PRVSVYDLVT SFIGYQEETL SLVLRKDIWN YEKSCAVSSN
GDFWNLDIFN RLKDVQTILN DVIYLSNNVN IDESQLHVYR DILDSWLAES KDIQVLTGSI
QKLEQSIVKF GEQLDLKSGT SMRLIWQNFK PSLPRSEEAW KRYDTMKLLA NRFDSISGTL
LPDSIEAVNS MRNSIIQTFF DVIDSSEADG SFNTVMGQLE AGISRLESLS TEFFEKRANN
FTYAFKLLFN AFEVYLTNSS SMKISSYSDN LMALAYYSNN GTLNLTRYTD STRKETYPSF
FKNLWNTENN GEQSMTRDLF GNGLLKEILF SQGKFSNIAV KDLKQSHSDL GSLGLQISKF
SEEVFANKVD LVKEILSNNI KELLLMHFIE AKIENPLVNL HDIAGLNSFI SQVENLNFKQ
VFSSYILPAI SLIIQDYDSY STQLSNVGAA WVLFSSAVIN IYVPDIPFDP AIREHVDFRR
TLAHYNKQVK DFASKKLTFN TFYNREDIGE EIGEILSEEP ATFRSLESEI FALHKEWEAF
VDSSIGLNPA SALLKSIQEE KENSNDRVKM FQINSTQFMN RVETRFGRYG DLSEILNGHI
YGMKLGFDMV SHSNETSKDE ESLAVFWSID ALLLSSPLSF LKEFSKIKIF IKNLPVDSFL
GEKVLVHLMR IGLLHKSVHN ANLFDEVLQY VFQTIYYRWS LRRLRSEESE TANSSLYKGH
DEEEEAEKEF AQLFPDYEEV LNFGEEKTGG STGPICDDEV SHEIMVAYIN LFKTKPNATL
LNTISSGVLL GHKIVNESSN SVPSSASSIL PGLINSHLAV LNGYEFNIKK SESFDFYRAS
RPQETTRVTT IISNLYKVIK GFSEKWPEHA TLQNILISSG ELLSYPITTP VARFLQKVEQ
IYSFLAEWQK LASREFSVTT QFDELTSLII SWRKLELSTW PSLFEFEESN SIKEMGKWWF
YLFENIIQNP SMIEDGEDME EIFVSMAQTL NIFVSQSTFG QYKTRIALLE SFRYHACALS
DSNPLFKRVA SLLDNIIIFY EQFVNEIDNA ISNSKQSLKK DFQDIILLAS WKDTNIIALK
ESARRSHHKL YKVVRKYRQV LAGLVTNVVE GGVQSSSADS PVRAKNVLLA VEVSDDKLDV
ARKSPVWGER PARLQNINLT IKNINVFVSS LRDSYVPSLQ ELAGEILEAM ETLKKETPGT
LTDTNKKEVS ALKARKSKFL SDTLKELQRL GLKVRVKPDV AARQSSVNQI LSSAPSFAGT
NVNIDDKYFF RILEMLPRLR AAVQNVAADV PVADIHRGLA ISENLLSIIL DQRNALYDVA
SKLERFNEMS DVIGSLSATN DIQDSLVLGL RLRDYSSVSE FVSWLLELLL FAISVCASLG
QLGNVSGSNL SSVLRSWVSR FTDSKHAWSK YDSLSRQQFI TNSTQSFLAQ LQDELDNLVK
DLAKSKKSES SVAFIVDLLL SWIKNNRSYV NDQVTPCSES FVSLTGLNQE LMKLSDMVLV
AVQKIHTLNK DIEEDEDNWF TDSQKLLVTY SRMLYVDQVT DKILHCLETY KNFSDNEDIN
NSVSTALFGL ALPFIKQYAN LIGTVLDKIR ANYSDVSKAS YILFKTLLNL ATSGFCSPEE
ASEEKDSGAT QDGTGLGDGE GAQDHSKDIE EDEDLSEYAQ TENKDQEKDQ DKGEDEEDNA
VEIEGDMAGQ VEDCSDQEKD DEDSEDEDGE EEELDEEVGE LDELDPNSVD EKMWDEEAGD
DKKEKESDDV PENGGTDDAP EANEDDAENT NQNQQTNEDG MQEDENASEG EEEEEEDVGF
QEDDVKQQET EELDPYVEET ETLELPDDLN LDGEDAKEND EESNEEFPDD GLDKMMEDDE
AMDEDSKDEE KDDETLEAGE ADEDQNEGNE SEDENKLDEE ELEGSADMEV DEDGNEDGNE
GEEGEELDDD LDPKKQKEEQ NEDNQAEESA MQADIDGLHG PDNDNQDNED TEDAAVKQES
GQKNEGADAS TETEENNAEN TGGDTSMKPE DQEEAEAKEE ENSDEARDNA NESLKQLGDA
LKEFHKRRQE IKEESERDND SDNSANTRPD DFEHVQGEDS SHDTQAMGSA TQDIKQQIDD
NMAIEDNDEI NNQAPEEHEA VKADNSVEQE DESMDEDSQD NDNSSDPSHG VAGSMVGERN
NEADDWRAYE HNDAMDIDSY EESEVDSLVD DNDGELLPYR DINEARAIWK DHELTTQELS
QGLTEQLRLI LEPTLATKLR GDFKTGKRLN MKRIIPYIAS QFKKDKIWMR RTKPSKRQYQ
IMIAVDDSKS MSESKSVNLA FQTIALVSKA LTQLESGQLA IARFGEFTQL VHPFQKPFSS
EAGSQVLQWF GFEQTKTDVK ALVNKSLEIF EEASRDANQN LWKLEIIISD GVCEDHDTLR
RLVRKAREEK IMLVFVIVDG INKEGSIMEM NQVKYDQNPD GSMALKMERY LDKFPFDFYV
IVKDIAELPG VLSLVLRQYF AEVA
//
