ID A0A1E3PV09_LIPST Unreviewed; 1315 AA.
AC A0A1E3PV09;
DT 18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT 18-JAN-2017, sequence version 1.
DT 24-JAN-2024, entry version 27.
DE RecName: Full=Mediator of RNA polymerase II transcription subunit 13 {ECO:0000256|ARBA:ARBA00019618, ECO:0000256|RuleBase:RU364134};
DE AltName: Full=Mediator complex subunit 13 {ECO:0000256|ARBA:ARBA00032008, ECO:0000256|RuleBase:RU364134};
GN ORFNames=LIPSTDRAFT_76029 {ECO:0000313|EMBL:ODQ69255.1};
OS Lipomyces starkeyi NRRL Y-11557.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Lipomycetaceae; Lipomyces.
OX NCBI_TaxID=675824 {ECO:0000313|EMBL:ODQ69255.1, ECO:0000313|Proteomes:UP000094385};
RN [1] {ECO:0000313|EMBL:ODQ69255.1, ECO:0000313|Proteomes:UP000094385}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NRRL Y-11557 {ECO:0000313|EMBL:ODQ69255.1,
RC ECO:0000313|Proteomes:UP000094385};
RX PubMed=27535936; DOI=10.1073/pnas.1603941113;
RA Riley R., Haridas S., Wolfe K.H., Lopes M.R., Hittinger C.T., Goeker M.,
RA Salamov A.A., Wisecaver J.H., Long T.M., Calvey C.H., Aerts A.L.,
RA Barry K.W., Choi C., Clum A., Coughlan A.Y., Deshpande S., Douglass A.P.,
RA Hanson S.J., Klenk H.-P., LaButti K.M., Lapidus A., Lindquist E.A.,
RA Lipzen A.M., Meier-Kolthoff J.P., Ohm R.A., Otillar R.P., Pangilinan J.L.,
RA Peng Y., Rokas A., Rosa C.A., Scheuner C., Sibirny A.A., Slot J.C.,
RA Stielow J.B., Sun H., Kurtzman C.P., Blackwell M., Grigoriev I.V.,
RA Jeffries T.W.;
RT "Comparative genomics of biotechnologically important yeasts.";
RL Proc. Natl. Acad. Sci. U.S.A. 113:9882-9887(2016).
CC -!- FUNCTION: Component of the SRB8-11 complex. The SRB8-11 complex is a
CC regulatory module of the Mediator complex which is itself involved in
CC regulation of basal and activated RNA polymerase II-dependent
CC transcription. The SRB8-11 complex may be involved in the
CC transcriptional repression of a subset of genes regulated by Mediator.
CC It may inhibit the association of the Mediator complex with RNA
CC polymerase II to form the holoenzyme complex.
CC {ECO:0000256|ARBA:ARBA00025661, ECO:0000256|RuleBase:RU364134}.
CC -!- SUBUNIT: Component of the SRB8-11 complex, which itself associates with
CC the Mediator complex. {ECO:0000256|RuleBase:RU364134}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|RuleBase:RU364134}.
CC -!- SIMILARITY: Belongs to the Mediator complex subunit 13 family.
CC {ECO:0000256|ARBA:ARBA00009354, ECO:0000256|RuleBase:RU364134}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; KV454304; ODQ69255.1; -; Genomic_DNA.
DR STRING; 675824.A0A1E3PV09; -.
DR OrthoDB; 9289at2759; -.
DR Proteomes; UP000094385; Unassembled WGS sequence.
DR GO; GO:0016592; C:mediator complex; IEA:InterPro.
DR GO; GO:0003712; F:transcription coregulator activity; IEA:InterPro.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR InterPro; IPR009401; Med13_C.
DR InterPro; IPR021643; Mediator_Med13_N.
DR InterPro; IPR041285; MID_MedPIWI.
DR PANTHER; PTHR48249; MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 13; 1.
DR PANTHER; PTHR48249:SF3; MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 13; 1.
DR Pfam; PF06333; Med13_C; 1.
DR Pfam; PF11597; Med13_N; 1.
DR Pfam; PF18296; MID_MedPIWI; 1.
PE 3: Inferred from homology;
KW Activator {ECO:0000256|RuleBase:RU364134};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU364134};
KW Reference proteome {ECO:0000313|Proteomes:UP000094385};
KW Repressor {ECO:0000256|ARBA:ARBA00022491, ECO:0000256|RuleBase:RU364134};
KW Transcription {ECO:0000256|ARBA:ARBA00023163,
KW ECO:0000256|RuleBase:RU364134};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015,
KW ECO:0000256|RuleBase:RU364134}.
FT DOMAIN 4..263
FT /note="Mediator complex subunit Med13 N-terminal"
FT /evidence="ECO:0000259|Pfam:PF11597"
FT DOMAIN 798..965
FT /note="MID"
FT /evidence="ECO:0000259|Pfam:PF18296"
FT DOMAIN 979..1304
FT /note="Mediator complex subunit Med13 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF06333"
FT REGION 298..361
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 526..585
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1141..1181
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 298..323
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 546..584
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1315 AA; 145309 MW; 12F192326F431A92 CRC64;
MTTSPEKNFS NVFKVGTFDQ IRYRVFVDPL SRPLKILLAE WSLRQKLRTS LVAYHNKELW
TFSLNEETNP AVPDSSFGLK GTKILRLNAQ KLTMRIEIST GSFLPSTLTI SDSTSPQVFP
AAYIPLMLAF TGLVSRHLTS DYDYIPIGSV LLSPTQTLLH YSLRLISSGT LLLIPHYQHS
TLCRLSSAEA EPSLDSKLVL APNGIHARFA GKAPELPVDA STIMSNLYMS SGYRVLNEES
WCKVRIEGSS TTCCWPSELC FMLPPWKSSG DVSDMEWFRM ADPLDEVEEF VLSFSRRNRS
TDSSPSAFSQ KESASNVASQ KKNAAAVYPT PPDPAQSQNR PPTAPTSADA DNGEYPLSSK
WNVVGDGEQS VARIGVAEED DGLLLGDAEE VTEADFNFFD DDHNSTLFGD NSDNEMNMAD
HTDFLNHDMN AFNLDHIMEA TTEEVAMHQQ SNQMIARNKD ASPVQTRQEA DKIMTPPLSP
LKVVAQTNTG AVIPLKRKSV FAPLTFQPNL VIALDPKYAL GGRFYVPEER SDSSDTEDEG
EDGSDKDYDY QVSKTPRSDR ADDKHESSRT DSRRGKDQPS EDFASDANDA RQLWWTLLSN
STASRDGYLM SAVPSSASRL TQSFLQKYAD SSFVDIENIL QTLSEFVVWD SSLLDSYIPP
TESRGVCGPD FVNVLRAIFG QIQPLSLQEY ALVSDGSSTP ANDFQSLPDK VEESTEGREA
LQDFILQVDI FNVGLPSSLS TSVMASDDPI IISKPTKSVF YIDPPHFSFM RMNSVLEVLP
PALRFWQIFG FAPQSGRKDV ISFMIYPGSH GMASAASSFL DRLKPVYEGS SLGNFEFGNA
GEYKNGLVPI GSSAQTTEEA LEDMRKTCVL LGRLLTDFVD PLPNIVIFVA TPFSDPASLL
HISHSVFQLK QEYVDRLGGS YENAGLNVVF QLLPTDFIAG KDTLVVPPQY KLVKFALTLY
DKCRPQLSNE DTLSENHYPA YTLARTRPSR IDFKVTSTPT PPPCLFVENT YVHIAYARSR
DRRFVSVAWA DQYGELARVK TFLVVRRDGA RPRSWEDVCG EIWERTIAIL PRVGGMQWRL
VFAKVGTMEQ DELDVWMNLA SHATKNVAAT FVCVEPNPSL TVLQTSDQVT AGQYYNIYST
PEATPQRHND SPSDNCGNSS TTPGVLPESV GTPSGTTPSS SSLGLGFSSS VAYNAVGDQD
AVLVDLKDET YGVIMNHKLL LDQLDMLSVR FSLASGYLVK PGPRPTGTLM SVLELSLLHS
PVKPPFEGVV EDLLRQYRAL ACYGSASAVS DGRNGILPWH VAAVEKMQRM LCFLL
//
