ID   A0A1E3Q3Q3_LIPST        Unreviewed;       587 AA.
AC   A0A1E3Q3Q3;
DT   18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT   18-JAN-2017, sequence version 1.
DT   22-FEB-2023, entry version 15.
DE   RecName: Full=3-beta hydroxysteroid dehydrogenase/isomerase domain-containing protein {ECO:0000259|Pfam:PF01073};
GN   ORFNames=LIPSTDRAFT_28714 {ECO:0000313|EMBL:ODQ72281.1};
OS   Lipomyces starkeyi NRRL Y-11557.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Lipomycetaceae; Lipomyces.
OX   NCBI_TaxID=675824 {ECO:0000313|EMBL:ODQ72281.1, ECO:0000313|Proteomes:UP000094385};
RN   [1] {ECO:0000313|EMBL:ODQ72281.1, ECO:0000313|Proteomes:UP000094385}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NRRL Y-11557 {ECO:0000313|EMBL:ODQ72281.1,
RC   ECO:0000313|Proteomes:UP000094385};
RX   PubMed=27535936; DOI=10.1073/pnas.1603941113;
RA   Riley R., Haridas S., Wolfe K.H., Lopes M.R., Hittinger C.T., Goeker M.,
RA   Salamov A.A., Wisecaver J.H., Long T.M., Calvey C.H., Aerts A.L.,
RA   Barry K.W., Choi C., Clum A., Coughlan A.Y., Deshpande S., Douglass A.P.,
RA   Hanson S.J., Klenk H.-P., LaButti K.M., Lapidus A., Lindquist E.A.,
RA   Lipzen A.M., Meier-Kolthoff J.P., Ohm R.A., Otillar R.P., Pangilinan J.L.,
RA   Peng Y., Rokas A., Rosa C.A., Scheuner C., Sibirny A.A., Slot J.C.,
RA   Stielow J.B., Sun H., Kurtzman C.P., Blackwell M., Grigoriev I.V.,
RA   Jeffries T.W.;
RT   "Comparative genomics of biotechnologically important yeasts.";
RL   Proc. Natl. Acad. Sci. U.S.A. 113:9882-9887(2016).
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DR   EMBL; KV454296; ODQ72281.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1E3Q3Q3; -.
DR   STRING; 675824.A0A1E3Q3Q3; -.
DR   OrthoDB; 1133at2759; -.
DR   Proteomes; UP000094385; Unassembled WGS sequence.
DR   GO; GO:0003854; F:3-beta-hydroxy-delta5-steroid dehydrogenase activity; IEA:InterPro.
DR   GO; GO:0006694; P:steroid biosynthetic process; IEA:InterPro.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   InterPro; IPR002225; 3Beta_OHSteriod_DH/Estase.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   PANTHER; PTHR43000:SF7; DTDP-D-GLUCOSE 4,6-DEHYDRATASE; 1.
DR   PANTHER; PTHR43000; DTDP-D-GLUCOSE 4,6-DEHYDRATASE-RELATED; 1.
DR   Pfam; PF01073; 3Beta_HSD; 1.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000094385}.
FT   DOMAIN          9..277
FT                   /note="3-beta hydroxysteroid dehydrogenase/isomerase"
FT                   /evidence="ECO:0000259|Pfam:PF01073"
SQ   SEQUENCE   587 AA;  63544 MW;  FD221DBBB4FE8F75 CRC64;
     MALDGTSIIV TGGCGQVGVA VVKHLQHKYP TATIAVLDLE KPLAGDACFI EKVTYYAGNI
     TDEAILKETF EAVKPLVVFH TAGLIPQIAK RLNMHTEKDF TAVNVQGTRN VLDAATAVGS
     VKALVFTSSS DVVKGDSWQD LAGVNESMEI PKVFDDPYAK SKALAESFIL SSSTAMLPTT
     AIRTHAVFSS NDNNLIPLMR SAPRNVHLGS GKNLYDFTYA PNLAIAHVLA AENLLNVSPT
     ETSNPLSAAG KPFFVTNAEP MPFRTFIKLV WAAFDASGGK EQAQVKGITI PAPVALVLTW
     MSEMAARIVR KEPFLTVKNL GDGLAQRWFD NSSATAVLGD GPMSSVGKKI DRSALENLLQ
     SCPVRVAELE AAYIIPFMVS KHSTTQTLLS MFAGTNKETI LSGKNLNSPN NIFCTDHDTR
     LLFDEFAVGV KFLNGQYWLR KVISKKALGI LSQYGDGEEV IFGTGSQGHE IDLPDGELFN
     IHLAIGRVLH ASGAGEIINK ILQDEEDYND GIVEDGASRC TWNRDLILVA TAAINSMRVD
     ALNDIELASG FFDEKNIVKS CTPYALLDEA NHATAKDDVQ KWSSFWL
//