ID A0A1E3Q688_LIPST Unreviewed; 1091 AA.
AC A0A1E3Q688;
DT 18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT 18-JAN-2017, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE RecName: Full=DUF726 domain protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=LIPSTDRAFT_71587 {ECO:0000313|EMBL:ODQ73219.1};
OS Lipomyces starkeyi NRRL Y-11557.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Lipomycetaceae; Lipomyces.
OX NCBI_TaxID=675824 {ECO:0000313|EMBL:ODQ73219.1, ECO:0000313|Proteomes:UP000094385};
RN [1] {ECO:0000313|EMBL:ODQ73219.1, ECO:0000313|Proteomes:UP000094385}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NRRL Y-11557 {ECO:0000313|EMBL:ODQ73219.1,
RC ECO:0000313|Proteomes:UP000094385};
RX PubMed=27535936; DOI=10.1073/pnas.1603941113;
RA Riley R., Haridas S., Wolfe K.H., Lopes M.R., Hittinger C.T., Goeker M.,
RA Salamov A.A., Wisecaver J.H., Long T.M., Calvey C.H., Aerts A.L.,
RA Barry K.W., Choi C., Clum A., Coughlan A.Y., Deshpande S., Douglass A.P.,
RA Hanson S.J., Klenk H.-P., LaButti K.M., Lapidus A., Lindquist E.A.,
RA Lipzen A.M., Meier-Kolthoff J.P., Ohm R.A., Otillar R.P., Pangilinan J.L.,
RA Peng Y., Rokas A., Rosa C.A., Scheuner C., Sibirny A.A., Slot J.C.,
RA Stielow J.B., Sun H., Kurtzman C.P., Blackwell M., Grigoriev I.V.,
RA Jeffries T.W.;
RT "Comparative genomics of biotechnologically important yeasts.";
RL Proc. Natl. Acad. Sci. U.S.A. 113:9882-9887(2016).
CC -!- SIMILARITY: Belongs to the TMCO4 family.
CC {ECO:0000256|ARBA:ARBA00009824}.
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DR EMBL; KV454294; ODQ73219.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1E3Q688; -.
DR STRING; 675824.A0A1E3Q688; -.
DR OrthoDB; 8526at2759; -.
DR Proteomes; UP000094385; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR007941; DUF726.
DR PANTHER; PTHR17920:SF24; LIPASE MIL1-RELATED; 1.
DR PANTHER; PTHR17920; TRANSMEMBRANE AND COILED-COIL DOMAIN-CONTAINING PROTEIN 4 TMCO4; 1.
DR Pfam; PF05277; DUF726; 1.
DR SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils}; Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000094385};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 602..632
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 638..665
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 1..26
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 205..254
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 301..324
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 472..501
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1007..1051
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 954..981
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 206..254
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1034..1051
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1091 AA; 120784 MW; 07A72DA66C03D683 CRC64;
MSWNESAVNS PARKPPVDDD PEFGHGEKLT FASFYDDDDR KVDDATLHTI TPNSSTYLSD
DEDIASNVWA SSDVPKQPTL STTDTYTSSM SSFAPTTPAA TNFTDVAEFP RRSSSSYTYT
PPSPPTPIHM AAVDTTPKLE VLDSEDVSLE LETVNKDNVL SESKVADTAD ISSVPVSAGQ
HRRSDTRAST ITEMGDLERH FFPNSASPEQ LVSSPVQASE WSHQQMVSPV LKQQERQHSE
LHGSNSNNAS LTTDANGENA FEKQAADESV ENETNEDGWQ EMPVYASHDI YDDDGNIIAH
EEVPSEDEEE ENKRRGGAGK GYTRVTLDEE DAENAGYIDE STKYLFRDDD PTDIQARNPL
NQMHATKELL TDTQRIAYVG LCKLAMVDMA TDLARKKGSQ KIARYMSTAY GSMAMWSQKM
IMRLYAHMDI TPEEQLMIEQ LSSHGVETMD LTPTLMQNAR VMNPMAHDDF NSSHTSHVLP
ASSSNASSQS DSPLPEYSSD TRPIEAVQSP AAIKDQKTLD IDIRWTVLCD LFLVLVADSA
YDARSRTLLE RVGAALDVIW LDIAKFEKRV TDALDIEEGS YQIWKEDDII EARRKRVLKK
KYMYMGLATL GGGLVIGLSA GILAPVIGAG LAAGFTTIGI AGTSGFLAGA GGTAIVTTTG
AVIGAKIGSQ GMARRMGHVK TFEFRPLHNN ERVNLIVTVS GWLSGKEDDV RLPFSTVDPI
MGDIFSLYWE PDMLTSMGQT INLLATEVIT QSIQQVLGST VLVALMSSLQ LPMMLSKLSY
LLDNPWSVSL DRAWAAGLIL ADTLIQRNLG VRPVTLVGFS LGARVIASCL IELSKRNAFG
LVQNVYIFGS PVVVKRDQFV KASSVVSGRF LNGYSRRDWI LGYLFRATSG GLGRIAGLAS
IEGIDGIENY DCTEFVDGHM GYREAMPRLL SACGWEVLSE EFTEIEDPDP DQQRERQREL
IAEFEEAKRR MERENGRVRK QGLFSKWMKP KRKEWWEMVE EDAHAEQARE GSSYGYGNGG
SSSRDHSDSR VSDDGYTPPP SIQENKNSYY RAGQTQYEYH FKTGADGSEA LFDVDAIRRE
IEKAKRERRH N
//
