ID A0A1E3Q9I7_LIPST Unreviewed; 1321 AA.
AC A0A1E3Q9I7;
DT 18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT 18-JAN-2017, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE RecName: Full=Rad50/SbcC-type AAA domain-containing protein {ECO:0000259|Pfam:PF13476};
GN ORFNames=LIPSTDRAFT_69941 {ECO:0000313|EMBL:ODQ74341.1};
OS Lipomyces starkeyi NRRL Y-11557.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Lipomycetaceae; Lipomyces.
OX NCBI_TaxID=675824 {ECO:0000313|EMBL:ODQ74341.1, ECO:0000313|Proteomes:UP000094385};
RN [1] {ECO:0000313|EMBL:ODQ74341.1, ECO:0000313|Proteomes:UP000094385}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NRRL Y-11557 {ECO:0000313|EMBL:ODQ74341.1,
RC ECO:0000313|Proteomes:UP000094385};
RX PubMed=27535936; DOI=10.1073/pnas.1603941113;
RA Riley R., Haridas S., Wolfe K.H., Lopes M.R., Hittinger C.T., Goeker M.,
RA Salamov A.A., Wisecaver J.H., Long T.M., Calvey C.H., Aerts A.L.,
RA Barry K.W., Choi C., Clum A., Coughlan A.Y., Deshpande S., Douglass A.P.,
RA Hanson S.J., Klenk H.-P., LaButti K.M., Lapidus A., Lindquist E.A.,
RA Lipzen A.M., Meier-Kolthoff J.P., Ohm R.A., Otillar R.P., Pangilinan J.L.,
RA Peng Y., Rokas A., Rosa C.A., Scheuner C., Sibirny A.A., Slot J.C.,
RA Stielow J.B., Sun H., Kurtzman C.P., Blackwell M., Grigoriev I.V.,
RA Jeffries T.W.;
RT "Comparative genomics of biotechnologically important yeasts.";
RL Proc. Natl. Acad. Sci. U.S.A. 113:9882-9887(2016).
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|ARBA:ARBA00001947};
CC -!- SIMILARITY: Belongs to the SMC family. RAD50 subfamily.
CC {ECO:0000256|ARBA:ARBA00009439}.
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DR EMBL; KV454292; ODQ74341.1; -; Genomic_DNA.
DR STRING; 675824.A0A1E3Q9I7; -.
DR OrthoDB; 5477220at2759; -.
DR Proteomes; UP000094385; Unassembled WGS sequence.
DR GO; GO:0030870; C:Mre11 complex; IEA:InterPro.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006302; P:double-strand break repair; IEA:InterPro.
DR GO; GO:0000723; P:telomere maintenance; IEA:InterPro.
DR Gene3D; 1.10.287.1490; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR038729; Rad50/SbcC_AAA.
DR InterPro; IPR004584; Rad50_eukaryotes.
DR NCBIfam; TIGR00606; rad50; 1.
DR PANTHER; PTHR18867:SF12; DNA REPAIR PROTEIN RAD50; 1.
DR PANTHER; PTHR18867; RAD50; 1.
DR Pfam; PF13476; AAA_23; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Meiosis {ECO:0000256|ARBA:ARBA00023254};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000094385};
KW Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT DOMAIN 6..230
FT /note="Rad50/SbcC-type AAA"
FT /evidence="ECO:0000259|Pfam:PF13476"
FT COILED 194..339
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 405..432
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 501..528
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 570..608
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 758..806
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 843..915
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 1321 AA; 152265 MW; 535972E885C698CA CRC64;
MSSIQKLSIQ GVRSFDNAER ETIHFYAPLT LIVGHNGSGK TTIIECLRYA TTGDLPPQNK
GGAFIHDPRI AGEKEVMAQV KLGFTSTNGM QMICTRSMQL TMKKTTRTFK TLDGQLLVMH
NGQRETISTR CAELDAQLPQ YLGVSKAILD YVVFCHQDES LWPLSEPAVL KKRFDEIFEA
LKYTKALDTI KSLRKEFATE IRLLQNDVDH LKNDKDRADK IRARADQLKS GIEKTKEEAS
ILGREMQHVE GQLNTLFKSG QEFQKVLSEL DQKRAHLAAL NEQALELEST IEVLRDSDED
LEKKKAEFSD HIHTRQEELR ELRNTVEKAK QELIHVRSKH SDALVQEGKL NAEAEAQKGR
LKKRQDLVKE ISDRHNIAGF GIMDLDRRQI DAFREKLMGA IRSSTNQVQR NKAEAEDQIG
SIQSKIQQIR EEKSSYEMRY KLSKNSNDKR QDDVRKLQAS IDAVTVEEAD IVYHASQLKS
AEQQLGDQRA AFEQANFTAQ QTEKAENLKD VERKLDAVSD ELTRSNKQTE MRANLGILHK
NSNSRDEQLN AVINTNRAKF KAFTGAELQR NTVEKQFRTA QERLQDTLNE ATRSYESCAK
ELSKIETQYS IVKGDLQKKS LERERSTKVF QDIVSPENGD DDYARAFQDC LRDAEKTVER
DRRNLNQCDF ILAYYRKARD SAMQKHECNL CRRPLKDRRD EIEDSDDLGH TTELEIFCEL
MDAQIEYFGN KSQLVDRLEE SEKILEETRG AAPHVTKMEE LDAVIPDLKA QLVQLESRLD
TAGREVEKST SEIADVRQRI SELESLRKVV NDIVRFTSEI SDMNLEIESY TSQLSDTGIG
RSVDEIEAER QHLNALASQY RKELTRITDE RDRQRTQINV LENQSRDKKA VLNDKKTKLQ
AKNDLISRAE ELRKETADTV SKMEQVKTHI NTMDPLLQSH AHDLEQTRSH FNKIESEKMK
EVADLNASLQ KFMAVHADIG KYEENGGDSR LEHAQQRTQK YANRMKTLVE ETDQLMERAN
LQDKELTSID MQERQISDNI LLRSLHDRIE ETRSRICELE QKNAIQERDA FEKKAQQLRI
HHARLNADYG SKVGEIKQMD DQFKRYEDEL RTEFLNVHET YRETLIKLKT TTASSEDLAK
YGKALDSGIM KYHSLKMEEI NRIIDELWKK TYSGTDVDTI LIRSDDESAK GNRSYNYRVC
MVKQDVELDM RGRCSAGQKV LASIIIRLAL AECFGVNCGI IALDEPTTNL DQENVQSLAR
SLGSIIDARR AQRNFQLIVI THDEDFLRYM NGSDYCEYYF RVSRNERQKS QIERQKISEV
F
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