ID A0A1E3QCU2_LIPST Unreviewed; 670 AA.
AC A0A1E3QCU2;
DT 18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT 18-JAN-2017, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE RecName: Full=DNA helicase {ECO:0000256|ARBA:ARBA00012551};
DE EC=3.6.4.12 {ECO:0000256|ARBA:ARBA00012551};
GN ORFNames=LIPSTDRAFT_1601 {ECO:0000313|EMBL:ODQ74847.1};
OS Lipomyces starkeyi NRRL Y-11557.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Lipomycetaceae; Lipomyces.
OX NCBI_TaxID=675824 {ECO:0000313|EMBL:ODQ74847.1, ECO:0000313|Proteomes:UP000094385};
RN [1] {ECO:0000313|EMBL:ODQ74847.1, ECO:0000313|Proteomes:UP000094385}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NRRL Y-11557 {ECO:0000313|EMBL:ODQ74847.1,
RC ECO:0000313|Proteomes:UP000094385};
RX PubMed=27535936; DOI=10.1073/pnas.1603941113;
RA Riley R., Haridas S., Wolfe K.H., Lopes M.R., Hittinger C.T., Goeker M.,
RA Salamov A.A., Wisecaver J.H., Long T.M., Calvey C.H., Aerts A.L.,
RA Barry K.W., Choi C., Clum A., Coughlan A.Y., Deshpande S., Douglass A.P.,
RA Hanson S.J., Klenk H.-P., LaButti K.M., Lapidus A., Lindquist E.A.,
RA Lipzen A.M., Meier-Kolthoff J.P., Ohm R.A., Otillar R.P., Pangilinan J.L.,
RA Peng Y., Rokas A., Rosa C.A., Scheuner C., Sibirny A.A., Slot J.C.,
RA Stielow J.B., Sun H., Kurtzman C.P., Blackwell M., Grigoriev I.V.,
RA Jeffries T.W.;
RT "Comparative genomics of biotechnologically important yeasts.";
RL Proc. Natl. Acad. Sci. U.S.A. 113:9882-9887(2016).
CC -!- SIMILARITY: Belongs to the DNA2/NAM7 helicase family.
CC {ECO:0000256|ARBA:ARBA00007913}.
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DR EMBL; KV454291; ODQ74847.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1E3QCU2; -.
DR STRING; 675824.A0A1E3QCU2; -.
DR OrthoDB; 170190at2759; -.
DR Proteomes; UP000094385; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR CDD; cd18808; SF1_C_Upf1; 1.
DR Gene3D; 2.40.30.270; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR041679; DNA2/NAM7-like_C.
DR InterPro; IPR041677; DNA2/NAM7_AAA_11.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR047187; SF1_C_Upf1.
DR InterPro; IPR004483; SMUBP-2/Hcs1-like.
DR InterPro; IPR048761; SMUBP-2_HCS1_1B.
DR NCBIfam; TIGR00376; IGHMBP2 family helicase; 1.
DR PANTHER; PTHR43788:SF19; DNA-BINDING PROTEIN SMUBP-2; 1.
DR PANTHER; PTHR43788; DNA2/NAM7 HELICASE FAMILY MEMBER; 1.
DR Pfam; PF13086; AAA_11; 1.
DR Pfam; PF13087; AAA_12; 1.
DR Pfam; PF21138; SMUBP-2_HCS1_1B; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Helicase {ECO:0000256|ARBA:ARBA00022806};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000094385}.
FT DOMAIN 18..135
FT /note="Helicase SMUBP-2/HCS1 1B"
FT /evidence="ECO:0000259|Pfam:PF21138"
FT DOMAIN 199..408
FT /note="DNA2/NAM7 helicase helicase"
FT /evidence="ECO:0000259|Pfam:PF13086"
FT DOMAIN 417..631
FT /note="DNA2/NAM7 helicase-like C-terminal"
FT /evidence="ECO:0000259|Pfam:PF13087"
SQ SEQUENCE 670 AA; 74674 MW; 115D96591D204EE5 CRC64;
MEDADIAAKL TERFKSALKK EREEDISQTQ AQLLSLPPKA LARRGLAILN LCVSNIRTAI
GGSMVLELEP DTAISTEIDK GVGIRTGDIV AVERIPSATE KRLKPTMSPR MEGVTLRVSP
KQIQVAVDDK FANAAVALDG RLWMTKLVNS VTYNRMNETM EHLTKLSAPT KLQRIVLGSI
KPSKPKAPEH PVKYFDNTLN DSQKDAVQFA LSASETGKTY TIIEVIRQLV EKGGRVLVCG
PSNISVDTIL ERLDGLIPPT KLLRVGHPAR ILASTQRHSL DIILRTSDAG QIVRDIRAEI
DDSFAKIKKT RSGREKSEIY QNIKHLRKEY RMREKKALTQ VLNQGLVVVC TLHGAGSSFL
SAIEFNAIII DEVSQSFEPQ CWIPLLMHPE AEKLIIAGDN KQLPPTIKAA MNEKVLGTTL
FDRLVAAHGE KIKKLLNVQY RMNDIIMQYP STSMYYGQLT AHDSVKGRTL ADLEYVMRSE
ETETKVLWVD TQGGEFPESI PDESIKTDVD VSSKYNDLEA WLVIEQVLEL LNKGVKMSDI
GIISPYNAQV TIISKRLEAC EEKGVIKNKT NEEEILEIST VDGFQGREKN AIIISLVRSN
ANGEIGFLTD DRRLNVAMTR PMRYLCVIGD TETLSKGSTF LTGWVDWATN YADIRYPDVG
EVLELAMRLS
//
