ID A0A1E3QGW0_LIPST Unreviewed; 664 AA.
AC A0A1E3QGW0;
DT 18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT 18-JAN-2017, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE RecName: Full=Peroxisomal targeting signal receptor {ECO:0000256|ARBA:ARBA00014710};
DE AltName: Full=Peroxin-5 {ECO:0000256|ARBA:ARBA00032505};
GN ORFNames=LIPSTDRAFT_592 {ECO:0000313|EMBL:ODQ76684.1};
OS Lipomyces starkeyi NRRL Y-11557.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Lipomycetaceae; Lipomyces.
OX NCBI_TaxID=675824 {ECO:0000313|EMBL:ODQ76684.1, ECO:0000313|Proteomes:UP000094385};
RN [1] {ECO:0000313|EMBL:ODQ76684.1, ECO:0000313|Proteomes:UP000094385}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NRRL Y-11557 {ECO:0000313|EMBL:ODQ76684.1,
RC ECO:0000313|Proteomes:UP000094385};
RX PubMed=27535936; DOI=10.1073/pnas.1603941113;
RA Riley R., Haridas S., Wolfe K.H., Lopes M.R., Hittinger C.T., Goeker M.,
RA Salamov A.A., Wisecaver J.H., Long T.M., Calvey C.H., Aerts A.L.,
RA Barry K.W., Choi C., Clum A., Coughlan A.Y., Deshpande S., Douglass A.P.,
RA Hanson S.J., Klenk H.-P., LaButti K.M., Lapidus A., Lindquist E.A.,
RA Lipzen A.M., Meier-Kolthoff J.P., Ohm R.A., Otillar R.P., Pangilinan J.L.,
RA Peng Y., Rokas A., Rosa C.A., Scheuner C., Sibirny A.A., Slot J.C.,
RA Stielow J.B., Sun H., Kurtzman C.P., Blackwell M., Grigoriev I.V.,
RA Jeffries T.W.;
RT "Comparative genomics of biotechnologically important yeasts.";
RL Proc. Natl. Acad. Sci. U.S.A. 113:9882-9887(2016).
CC -!- SUBUNIT: Interacts (via WxxxF/Y and LVxEF motifs) with PEX14; promoting
CC translocation through the PEX13-PEX14 docking complex.
CC {ECO:0000256|ARBA:ARBA00038659}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol
CC {ECO:0000256|ARBA:ARBA00004514}. Peroxisome matrix
CC {ECO:0000256|ARBA:ARBA00004253}.
CC -!- SIMILARITY: Belongs to the peroxisomal targeting signal receptor
CC family. {ECO:0000256|ARBA:ARBA00005348}.
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DR EMBL; KV454289; ODQ76684.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1E3QGW0; -.
DR STRING; 675824.A0A1E3QGW0; -.
DR OrthoDB; 2020042at2759; -.
DR Proteomes; UP000094385; Unassembled WGS sequence.
DR GO; GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
DR GO; GO:0005782; C:peroxisomal matrix; IEA:UniProtKB-SubCell.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 1.
DR InterPro; IPR024111; PEX5/PEX5L.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR001440; TPR_1.
DR InterPro; IPR019734; TPR_repeat.
DR PANTHER; PTHR10130:SF0; GH08708P; 1.
DR PANTHER; PTHR10130; PEROXISOMAL TARGETING SIGNAL 1 RECEPTOR PEX5; 1.
DR Pfam; PF00515; TPR_1; 1.
DR Pfam; PF13432; TPR_16; 1.
DR Pfam; PF13181; TPR_8; 1.
DR SMART; SM00028; TPR; 4.
DR SUPFAM; SSF48452; TPR-like; 1.
DR PROSITE; PS50005; TPR; 3.
DR PROSITE; PS50293; TPR_REGION; 1.
PE 3: Inferred from homology;
KW Peroxisome {ECO:0000256|ARBA:ARBA00023140};
KW Protein transport {ECO:0000256|ARBA:ARBA00022927};
KW Reference proteome {ECO:0000313|Proteomes:UP000094385};
KW Thioester bond {ECO:0000256|ARBA:ARBA00022966};
KW TPR repeat {ECO:0000256|ARBA:ARBA00022803, ECO:0000256|PROSITE-
KW ProRule:PRU00339}; Translocation {ECO:0000256|ARBA:ARBA00023010};
KW Transport {ECO:0000256|ARBA:ARBA00022448};
KW Ubl conjugation {ECO:0000256|ARBA:ARBA00022843}.
FT REPEAT 401..434
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 511..544
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 545..578
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REGION 19..58
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 97..120
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 33..58
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 98..120
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 664 AA; 73923 MW; 0F8C5035B1710AF7 CRC64;
MSFMGSSAAD CAVGRNPLSH LTKHMGQDQS LQRDRFAGPS DSESSSAPGA SMRLSHGQPI
SANDREMMER FMSSQSSSPA PHDAFAFDAM RREVINISSP PPLSQQPQSH GSPAPSFQQR
PISDDRWAQD FRAPQFAGPQ TSRVSEWMAE YAIPSSASSS GMPTYAQPRM AYGIGSMPMT
GLYNSDMMYG RTHMPGVAGF GPGATVSHGK GKGRLVELDS ADWEEQFKSI EAEHERDDTI
EDAVQREVNY IDRDLHESYT GETLDETYHG DFENIWRGIQ EQHMHDGTAQ EIGNQNNIDL
TYNNLFGGDR FLDTSDFDQT NPFAVEGVDG ELQMPWDRDF EEYATLRSEA GNYQYELDNR
YMDPDMSDPF AEGVRIMETG GNLSEAALAF EAAVQKNPEH IEAWALLGAV QAQNEKEDPA
IRALERAVQL DPNNQSALMN LAVSYINEGY ENAAYATLER WIATKYPDIV AQARGQPPQL
SDVDRFRLHD RVTELFLRAA QLSPEGMTMD ADVQVGLGVL FYGNEEYDKA VDCFNTALSV
RPDDPLLWNR LGATLANSHR SEEAIEAYYK ALELRPSFVR ARYNLGVSCI NIGCYKEAAQ
HLLGALDMHR VPNGQTELGE DDVLANQSTN LYDTLRRVFL AMDRRDLADK VVNGVDPAVF
KDSF
//
