ID A0A1E3QW23_9ASCO Unreviewed; 1032 AA.
AC A0A1E3QW23;
DT 18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT 18-JAN-2017, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE RecName: Full=non-specific serine/threonine protein kinase {ECO:0000256|ARBA:ARBA00012513};
DE EC=2.7.11.1 {ECO:0000256|ARBA:ARBA00012513};
GN ORFNames=BABINDRAFT_170486 {ECO:0000313|EMBL:ODQ81858.1};
OS Babjeviella inositovora NRRL Y-12698.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; CUG-Ser1 clade incertae sedis; Babjeviella.
OX NCBI_TaxID=984486 {ECO:0000313|EMBL:ODQ81858.1, ECO:0000313|Proteomes:UP000094336};
RN [1] {ECO:0000313|Proteomes:UP000094336}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NRRL Y-12698 {ECO:0000313|Proteomes:UP000094336};
RG DOE Joint Genome Institute;
RA Riley R., Haridas S., Wolfe K.H., Lopes M.R., Hittinger C.T., Goker M.,
RA Salamov A., Wisecaver J., Long T.M., Aerts A.L., Barry K., Choi C.,
RA Clum A., Coughlan A.Y., Deshpande S., Douglass A.P., Hanson S.J.,
RA Klenk H.-P., Labutti K., Lapidus A., Lindquist E., Lipzen A.,
RA Meier-Kolthoff J.P., Ohm R.A., Otillar R.P., Pangilinan J., Peng Y.,
RA Rokas A., Rosa C.A., Scheuner C., Sibirny A.A., Slot J.C., Stielow J.B.,
RA Sun H., Kurtzman C.P., Blackwell M., Grigoriev I.V., Jeffries T.W.;
RT "Comparative genomics of biotechnologically important yeasts.";
RL Submitted (MAY-2016) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; KV454427; ODQ81858.1; -; Genomic_DNA.
DR RefSeq; XP_018987186.1; XM_019130746.1.
DR AlphaFoldDB; A0A1E3QW23; -.
DR STRING; 984486.A0A1E3QW23; -.
DR GeneID; 30148599; -.
DR OrthoDB; 1630at2759; -.
DR Proteomes; UP000094336; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0004521; F:RNA endonuclease activity; IEA:InterPro.
DR GO; GO:0030968; P:endoplasmic reticulum unfolded protein response; IEA:InterPro.
DR GO; GO:0006397; P:mRNA processing; IEA:InterPro.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd10422; RNase_Ire1; 1.
DR Gene3D; 1.20.1440.180; KEN domain; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR045133; IRE1/2-like.
DR InterPro; IPR010513; KEN_dom.
DR InterPro; IPR038357; KEN_sf.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR011047; Quinoprotein_ADH-like_supfam.
DR InterPro; IPR008271; Ser/Thr_kinase_AS.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR PANTHER; PTHR13954; IRE1-RELATED; 1.
DR PANTHER; PTHR13954:SF6; NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE; 1.
DR Pfam; PF00069; Pkinase; 1.
DR Pfam; PF06479; Ribonuc_2-5A; 1.
DR SMART; SM00580; PUG; 1.
DR SMART; SM00220; S_TKc; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR SUPFAM; SSF50998; Quinoprotein alcohol dehydrogenase-like; 1.
DR PROSITE; PS51392; KEN; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Kinase {ECO:0000256|ARBA:ARBA00022527};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000094336};
KW Serine/threonine-protein kinase {ECO:0000256|ARBA:ARBA00022527};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 593..900
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT DOMAIN 903..1032
FT /note="KEN"
FT /evidence="ECO:0000259|PROSITE:PS51392"
FT REGION 490..546
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 562..588
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 490..511
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1032 AA; 116255 MW; 601D0487677840AF CRC64;
MYVYRFALIP ILRELPYTFE CDCIIRIYAT LKLQTTHSLL KVASELYARP LEAWDVTDTL
LASDIEGALH GLNRTTGEVL WTLPGTPLVQ IVNQTHTSPE DQRSEVIWAV EPLDDGRLYY
FSKEMGLQEF PVSIKHLVLE SPFVLSGDDK IYTGAMRSLL YDIRVSDGEV LGTYGPGSPS
MQCPVDPRGP EEPHVYVSQT IYELTIQGSN QGKDQATWKV TYASWGPNNM DKDLVQQSRY
PRDMFLAPNY DASVLAMDLE LPTPKWVSRL PAIAVNVFDI FLSHSAELAV LPHPLKPDSE
AFNPKADYGT FLDQTSTGSW YAMSGFNYPL LVASAPRSQY WTSSRWHSRD VPSSPDFENL
TLNGVHKSLV LETTHTRERL PSPAATILKN LPATTTTTTP WGHQRIPKPI QPVTLDITED
YLTMSLGKIV LRIVENAVTT LVVVMVMVGL GKMGVIPPFT KILVKLGFFR RTQNAIEIVE
KMLSEEEVDL ARELSTPEPD DKRKKSVTIL DHGEISKTTD AVSSPEDAGP KRRKRGSRGG
KKNKKESEIA LESLSLEVDS SISSEVGSST KSEGSLLSEV GSANSRSSTG NLVISDTVLG
YGSHGTVVYK GTFESRPVAV KRMLLDFFDV AQHEVALLQE SDDHPNVVRY FCSQESEKFL
YIALELCSAS LEDVVEKAQR YPELSSMRPN TILYQIACGL NYLHSLKIVH RDLKPQNILV
APPKHRHRGE AVPPRTLISD FGLCKKLEAD QSSFRATTAN AAGTAGWRAP ELLVDEHDSV
YNNIITNGTM TSDLNHSIPG MNATGASEPL VYDSLSKRKL TRAIDVFSMG CVFYYVLTSG
QHPFGDRYLR EGNIIKGEYC LDLLDVLPDA FEARHLIAHM IARNPRLRLD SLQIMKHPYF
WLYEKRFDFL LKVSDRFEVE RRDPPSPLLL KLEEIAPQVV GKDWRAKFGR LFLDNLGKYR
KYHGLKLMDL LRALRNKYHH FNDMPEALME EMGPLPDGFY AYFNSRFPNM LMEIYFVVQE
NLADEQTLRA FY
//
