ID A0A1E3R3V8_9MYCO Unreviewed; 785 AA.
AC A0A1E3R3V8;
DT 18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT 18-JAN-2017, sequence version 1.
DT 27-MAR-2024, entry version 36.
DE SubName: Full=Glycosyl hydrolase {ECO:0000313|EMBL:ODQ84620.1};
GN ORFNames=BHQ17_26620 {ECO:0000313|EMBL:ODQ84620.1};
OS Mycolicibacterium holsaticum.
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC Mycolicibacterium.
OX NCBI_TaxID=152142 {ECO:0000313|EMBL:ODQ84620.1, ECO:0000313|Proteomes:UP000094243};
RN [1] {ECO:0000313|Proteomes:UP000094243}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=M7 {ECO:0000313|Proteomes:UP000094243};
RA Greninger A.L., Jerome K.R., Mcnair B., Wallis C., Fang F.;
RL Submitted (SEP-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the glycosyl hydrolase 65 family.
CC {ECO:0000256|ARBA:ARBA00006768}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ODQ84620.1}.
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DR EMBL; MIGZ01000259; ODQ84620.1; -; Genomic_DNA.
DR RefSeq; WP_069408006.1; NZ_MIGZ01000259.1.
DR AlphaFoldDB; A0A1E3R3V8; -.
DR OrthoDB; 9816160at2; -.
DR Proteomes; UP000094243; Unassembled WGS sequence.
DR GO; GO:0030246; F:carbohydrate binding; IEA:InterPro.
DR GO; GO:0016798; F:hydrolase activity, acting on glycosyl bonds; IEA:UniProtKB-KW.
DR GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR Gene3D; 1.50.10.10; -; 1.
DR Gene3D; 2.70.98.40; Glycoside hydrolase, family 65, N-terminal domain; 1.
DR Gene3D; 2.60.420.10; Maltose phosphorylase, domain 3; 1.
DR InterPro; IPR008928; 6-hairpin_glycosidase_sf.
DR InterPro; IPR012341; 6hp_glycosidase-like_sf.
DR InterPro; IPR011013; Gal_mutarotase_sf_dom.
DR InterPro; IPR005194; Glyco_hydro_65_C.
DR InterPro; IPR005195; Glyco_hydro_65_M.
DR InterPro; IPR005196; Glyco_hydro_65_N.
DR InterPro; IPR037018; Glyco_hydro_65_N_sf.
DR InterPro; IPR017045; Malt_Pase/Glycosyl_Hdrlase.
DR PANTHER; PTHR11051; GLYCOSYL HYDROLASE-RELATED; 1.
DR PANTHER; PTHR11051:SF13; GLYCOSYL TRANSFERASE-RELATED; 1.
DR Pfam; PF03633; Glyco_hydro_65C; 1.
DR Pfam; PF03632; Glyco_hydro_65m; 1.
DR Pfam; PF03636; Glyco_hydro_65N; 1.
DR PIRSF; PIRSF036289; Glycosyl_hydrolase_malt_phosph; 1.
DR SUPFAM; SSF74650; Galactose mutarotase-like; 1.
DR SUPFAM; SSF48208; Six-hairpin glycosidases; 1.
PE 3: Inferred from homology;
KW Glycosidase {ECO:0000256|ARBA:ARBA00023295};
KW Hydrolase {ECO:0000313|EMBL:ODQ84620.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000094243}.
FT DOMAIN 16..270
FT /note="Glycoside hydrolase family 65 N-terminal"
FT /evidence="ECO:0000259|Pfam:PF03636"
FT DOMAIN 327..677
FT /note="Glycoside hydrolase family 65 central catalytic"
FT /evidence="ECO:0000259|Pfam:PF03632"
FT DOMAIN 687..750
FT /note="Glycoside hydrolase family 65 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03633"
FT REGION 752..785
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 762..776
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 488
FT /note="Proton donor"
FT /evidence="ECO:0000256|PIRSR:PIRSR036289-50"
FT BINDING 361..362
FT /ligand="substrate"
FT /evidence="ECO:0000256|PIRSR:PIRSR036289-51"
FT BINDING 590..591
FT /ligand="substrate"
FT /evidence="ECO:0000256|PIRSR:PIRSR036289-51"
SQ SEQUENCE 785 AA; 87508 MW; 6C0400B3165F3175 CRC64;
MITDELYPVE PWHIRETSLD LAILDESESI FALSNGHIGL RANLDEGEPH SLPGTYLNSF
YEVRPLPYAE AGYGYPEAGQ TVVNVTNGKL LRLLVDDEPF DVRYGELLEH ERVLDMRAGT
LTRTVQWRSP VGKQVKLVSA RLVSLNQRGV AAIEYTVEAV DEFARITVQS ELVANEDQPP
TSADPRVSAV LNHPLEAVHQ ESIGDGAILI HRTRASGLMM AAAMDHEIDV PGRVEVTTDT
SDDWARTTVI CGLRPGQRLR IRKYLAYAWS SLRSRPALRD QVAAALSGAE YTGWQGLLDA
QRAYLDDFWD SADVEVEGDP HIQQAVRFAL FHVLQASARA ERRAIPSKGL TGTGYDGHAF
WDTEGFVLPL LTYTAPYAAA DALRWRASTL DLAKERAELL DLEGATFPWR TIRGEECSAY
WPAGTAAFHV NADIAMAFER YRVVTGDDSL DTECGLKVLV ETARMWLSLG QHDRHGVWHI
DGVTGPDEYT AVVRDNVFTN LMAARNLRAA ADACVRHPDE ANAIDVTAEE IDAWRHAAAT
VHIPFDEDLG VHPQCEGFTT LREWDFAANT AYPLLLHEPY VRLYPQQVVK QADLVLAMHW
ESHAFTPEQM ARNVDYYEQR TTRDSSLSAC TQAVMCAAVG HLELAHDYAY EAAMIDLRNL
HHNTRDGLHM ASLAGAWSAL VAGFGGLRDD EDLLALDPHL PETLSRLKFR LRWKNFRLTV
DVNHEDVTYT LRDGPDTSLT IRHAGEDLEL KTQSPTTVAV KPVRPLLPPP KQPPGRAPMR
HNQII
//
