ID A0A1E3R5R5_9MYCO Unreviewed; 319 AA.
AC A0A1E3R5R5;
DT 18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT 18-JAN-2017, sequence version 1.
DT 24-JAN-2024, entry version 32.
DE SubName: Full=5'-3' exonuclease {ECO:0000313|EMBL:ODQ85250.1};
GN ORFNames=BHQ17_23980 {ECO:0000313|EMBL:ODQ85250.1};
OS Mycolicibacterium holsaticum.
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC Mycolicibacterium.
OX NCBI_TaxID=152142 {ECO:0000313|EMBL:ODQ85250.1, ECO:0000313|Proteomes:UP000094243};
RN [1] {ECO:0000313|Proteomes:UP000094243}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=M7 {ECO:0000313|Proteomes:UP000094243};
RA Greninger A.L., Jerome K.R., Mcnair B., Wallis C., Fang F.;
RL Submitted (SEP-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ODQ85250.1}.
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DR EMBL; MIGZ01000194; ODQ85250.1; -; Genomic_DNA.
DR RefSeq; WP_069407567.1; NZ_MIGZ01000194.1.
DR AlphaFoldDB; A0A1E3R5R5; -.
DR OrthoDB; 9806424at2; -.
DR Proteomes; UP000094243; Unassembled WGS sequence.
DR GO; GO:0017108; F:5'-flap endonuclease activity; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0004527; F:exonuclease activity; IEA:UniProtKB-KW.
DR GO; GO:0033567; P:DNA replication, Okazaki fragment processing; IEA:InterPro.
DR CDD; cd09898; H3TH_53EXO; 1.
DR CDD; cd09859; PIN_53EXO; 1.
DR Gene3D; 1.10.150.20; 5' to 3' exonuclease, C-terminal subdomain; 1.
DR Gene3D; 3.40.50.1010; 5'-nuclease; 1.
DR InterPro; IPR020046; 5-3_exonucl_a-hlix_arch_N.
DR InterPro; IPR002421; 5-3_exonuclease.
DR InterPro; IPR036279; 5-3_exonuclease_C_sf.
DR InterPro; IPR020045; DNA_polI_H3TH.
DR InterPro; IPR038969; FEN.
DR InterPro; IPR008918; HhH2.
DR InterPro; IPR029060; PIN-like_dom_sf.
DR PANTHER; PTHR42646:SF2; DNA-DIRECTED DNA POLYMERASE; 1.
DR PANTHER; PTHR42646; FLAP ENDONUCLEASE XNI; 1.
DR Pfam; PF01367; 5_3_exonuc; 1.
DR Pfam; PF02739; 5_3_exonuc_N; 1.
DR SMART; SM00475; 53EXOc; 1.
DR SMART; SM00279; HhH2; 1.
DR SUPFAM; SSF47807; 5' to 3' exonuclease, C-terminal subdomain; 1.
DR SUPFAM; SSF88723; PIN domain-like; 1.
PE 4: Predicted;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Exonuclease {ECO:0000313|EMBL:ODQ85250.1};
KW Hydrolase {ECO:0000313|EMBL:ODQ85250.1};
KW Nuclease {ECO:0000313|EMBL:ODQ85250.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000094243}.
FT DOMAIN 3..284
FT /note="5'-3' exonuclease"
FT /evidence="ECO:0000259|SMART:SM00475"
SQ SEQUENCE 319 AA; 34066 MW; 8B63418F07299551 CRC64;
MPAPLLLLDG ASMWFRSYFG VPSSITAPDG RPVNAVRGFL DAVATVITRE RPERLVVCRD
DDWRPQWRVD LIPSYKAHRV EEPQPDGTPD IEEVPDDLTP QVDMILEILD AFGIATAGAA
EHEADDVLGT LATRERRSPV VVVSGDRDLL QLVGDDPVPV RVLYIGRGLA KATLFGPKEV
AETYGVPVHR AGPAYAELAL LRGDPSDGLP GVPGVGEKTA ATLLAQHGSL ENIMAAAHDP
KSKMSKAFRT KLLAATDYIE AAGPVVRVAT GCDVDFSTPD DTLPLAAGQP RKVAELAQTY
GVTSSIGRLQ KALDGLPAR
//
