ID A0A1E3S0S0_9MYCO Unreviewed; 967 AA.
AC A0A1E3S0S0;
DT 18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT 18-JAN-2017, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE RecName: Full=Membrane transport protein MMPL domain-containing protein {ECO:0000259|Pfam:PF03176};
GN ORFNames=BHQ17_04065 {ECO:0000313|EMBL:ODQ95684.1};
OS Mycolicibacterium holsaticum.
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC Mycolicibacterium.
OX NCBI_TaxID=152142 {ECO:0000313|EMBL:ODQ95684.1, ECO:0000313|Proteomes:UP000094243};
RN [1] {ECO:0000313|Proteomes:UP000094243}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=M7 {ECO:0000313|Proteomes:UP000094243};
RA Greninger A.L., Jerome K.R., Mcnair B., Wallis C., Fang F.;
RL Submitted (SEP-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the resistance-nodulation-cell division (RND)
CC (TC 2.A.6) family. MmpL subfamily. {ECO:0000256|ARBA:ARBA00010157}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ODQ95684.1}.
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DR EMBL; MIGZ01000014; ODQ95684.1; -; Genomic_DNA.
DR RefSeq; WP_069403954.1; NZ_MIGZ01000014.1.
DR AlphaFoldDB; A0A1E3S0S0; -.
DR OrthoDB; 4758927at2; -.
DR Proteomes; UP000094243; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR Gene3D; 1.20.1640.10; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR InterPro; IPR004869; MMPL_dom.
DR InterPro; IPR004707; MmpL_fam.
DR NCBIfam; TIGR00833; actII; 1.
DR PANTHER; PTHR33406; MEMBRANE PROTEIN MJ1562-RELATED; 1.
DR PANTHER; PTHR33406:SF6; MEMBRANE PROTEIN SCO0839-RELATED; 1.
DR Pfam; PF03176; MMPL; 2.
DR SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 2.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000094243};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 24..47
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 227..247
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 253..277
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 306..324
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 336..361
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 382..404
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 773..791
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 798..824
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 830..852
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 873..894
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 900..922
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 61..389
FT /note="Membrane transport protein MMPL"
FT /evidence="ECO:0000259|Pfam:PF03176"
FT DOMAIN 611..945
FT /note="Membrane transport protein MMPL"
FT /evidence="ECO:0000259|Pfam:PF03176"
SQ SEQUENCE 967 AA; 105072 MW; EB422817648F3F08 CRC64;
MTHPSDPKTE PLRTAKRPPF VAKLVHRFSV PIILGWLAVA VLLTMGVPSL EMVEKQHPVE
MSPTAAPSFQ AMQRMGAVFD EANSGAVAMI VFEGQQPLGD DTHAYYDELV KALRDDTTHV
QHVQDFWGDP ITQGAAQSAD GKAAYVQVNL AANRDGVTVN ESLRAIRDIV DRTPPPNGVE
AFVTGPAAFA ADLGPAGNRT VLLVTSLSFA VIFTMLLLVY RSVITVVLLL LIVVVELIIA
RGTVAFLGDL EVIGITTFVV NLLVPLAIAA GTDYGIFFTG RYQEARQAGE DRETAFYTTY
HSVAKVVLAS GFTIAGAVLC LRFTRLPVYQ TLGVPTAVGM VIAVLVAVTL VPAVIAAGSR
IGLFEPKRKL ATRRWRRVGT AVVRWPAPIL AATLAVSLIG LLALPGYQAS YNDQAYLPKD
IPASVGYAAA ERHFPQSLMM APDILLIEAD HDMRNSADFL VLNKLAKAVQ GVEGVSRVQA
VTRPGGEPLN NTTIPFMLSM SSASQSQLLP FQKARMDDLL VQADDMLETI AIMKRMQALT
EEMVSTTHDM VAKTHELEDI TNQLRDNVAN FDDFFRPIRN YLYWEPHCYN IPLCFAVRSV
FDTLDGVDQI TAKLRGLVDN LDRLDKILPQ MAEQFPVMIE TMRSTREMML TMHSTMSGIL
AQMEETNDNA TAMGKAFNAA KNDDSFYLPP EVFDNEDFKR VMNVFLSPDG KAARMLISQR
GDPATTEGMS RVDPILTAAQ EALKGTPLQS ADIYLTGTAA SVKDIVEGST YDLLIAATAA
LCLIFCIMLI ITRSFIAALV IVGTVALSLG AAFGLSVLIW QHILGIPLNW VVLAMSVIIL
LAVGSDYNLL LVSRMKEEIG AGLNTGIIRA MGGSGKVVTA AGLVFAFTML SMVVSDLQTI
GQLGSTIGVG LLFDTLVVRA FMTPSIAALL GRWFWWPLQV HPRPASAARR TRGPRPLVRS
LLQKDER
//
