ID   A0A1E3S2S8_9MYCO        Unreviewed;       460 AA.
AC   A0A1E3S2S8;
DT   18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT   18-JAN-2017, sequence version 1.
DT   24-JAN-2024, entry version 32.
DE   SubName: Full=Sodium:alanine symporter {ECO:0000313|EMBL:ODQ96473.1};
GN   ORFNames=BHQ17_00910 {ECO:0000313|EMBL:ODQ96473.1};
OS   Mycolicibacterium holsaticum.
OC   Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC   Mycolicibacterium.
OX   NCBI_TaxID=152142 {ECO:0000313|EMBL:ODQ96473.1, ECO:0000313|Proteomes:UP000094243};
RN   [1] {ECO:0000313|Proteomes:UP000094243}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=M7 {ECO:0000313|Proteomes:UP000094243};
RA   Greninger A.L., Jerome K.R., Mcnair B., Wallis C., Fang F.;
RL   Submitted (SEP-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|RuleBase:RU363064};
CC       Multi-pass membrane protein {ECO:0000256|RuleBase:RU363064}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the alanine or glycine:cation symporter (AGCS)
CC       (TC 2.A.25) family. {ECO:0000256|ARBA:ARBA00009261,
CC       ECO:0000256|RuleBase:RU363064}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:ODQ96473.1}.
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DR   EMBL; MIGZ01000003; ODQ96473.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1E3S2S8; -.
DR   Proteomes; UP000094243; Unassembled WGS sequence.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005283; F:amino acid:sodium symporter activity; IEA:InterPro.
DR   Gene3D; 1.20.1740.10; Amino acid/polyamine transporter I; 1.
DR   InterPro; IPR001463; Na/Ala_symport.
DR   NCBIfam; TIGR00835; agcS; 1.
DR   PANTHER; PTHR30330; AGSS FAMILY TRANSPORTER, SODIUM-ALANINE; 1.
DR   PANTHER; PTHR30330:SF3; TRANSCRIPTIONAL REGULATOR, LRP FAMILY-RELATED; 1.
DR   Pfam; PF01235; Na_Ala_symp; 1.
DR   PRINTS; PR00175; NAALASMPORT.
PE   3: Inferred from homology;
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475,
KW   ECO:0000256|RuleBase:RU363064};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU363064};
KW   Reference proteome {ECO:0000313|Proteomes:UP000094243};
KW   Symport {ECO:0000256|RuleBase:RU363064};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU363064};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|RuleBase:RU363064};
KW   Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU363064}.
FT   TRANSMEM        12..33
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU363064"
FT   TRANSMEM        144..164
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU363064"
FT   TRANSMEM        184..203
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU363064"
FT   TRANSMEM        212..233
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU363064"
FT   TRANSMEM        239..266
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU363064"
FT   TRANSMEM        308..328
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU363064"
FT   TRANSMEM        352..374
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU363064"
FT   TRANSMEM        394..414
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU363064"
FT   TRANSMEM        420..438
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU363064"
SQ   SEQUENCE   460 AA;  48520 MW;  F863B6044F29FAA2 CRC64;
     MDNLLGDVSS FIWGPWLLIP LLLLTGLYLT VLLRGIQVRR FRLAFWLAFV KRKDLGAEGD
     ISHYQALSTA LAATVGVGNI AGVATAIALG GPGAVFWMWF TGMVGMATKY SEAFLGVRFR
     RTDAAGEQSG GPMHYLRRGI KGPLGVFLGG FFAIAGALAA FGIGNMTQAN TVAANVEEEW
     GVSAPITGAV IVVLAAAVIL GGIKSIGRVT SLFVPVMIVF YIVGAAAVLA FNIGEVPAAL
     GLIFTDAFTG TSATGGFAGA AVAAAIRYGV ARGIFSNESG LGTGGIAAAA AKTTHPVRQA
     LVSMTQTFID TLVVVSFTAL TIVVTGVWKE AGPDEAASFT ARAFAEGLPG GWASIIVTLS
     VIFFAFSTLL GWSYYGERCV EYLFGRKAVV PYRILFIIVI YIGSTTALQT VWTFSDVMNG
     LMALPNLIGL VILSPLVYRE TRAYFRGEHH AEDMRIRSGV
//