ID A0A1E3T265_9MYCO Unreviewed; 267 AA.
AC A0A1E3T265;
DT 18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT 18-JAN-2017, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE RecName: Full=NADP-dependent 3-hydroxy acid dehydrogenase YdfG {ECO:0000256|ARBA:ARBA00044065};
DE EC=1.1.1.298 {ECO:0000256|ARBA:ARBA00044050};
DE EC=1.1.1.381 {ECO:0000256|ARBA:ARBA00044059};
DE AltName: Full=L-allo-threonine dehydrogenase {ECO:0000256|ARBA:ARBA00044349};
DE AltName: Full=Malonic semialdehyde reductase {ECO:0000256|ARBA:ARBA00044271};
GN ORFNames=AWC25_14315 {ECO:0000313|EMBL:ORW75361.1}, BHQ21_06665
GN {ECO:0000313|EMBL:ODR08474.1};
OS Mycobacterium sherrisii.
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC Mycobacterium; Mycobacterium simiae complex.
OX NCBI_TaxID=243061 {ECO:0000313|EMBL:ODR08474.1, ECO:0000313|Proteomes:UP000094224};
RN [1] {ECO:0000313|EMBL:ORW75361.1, ECO:0000313|Proteomes:UP000193024}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC BAA-832 {ECO:0000313|EMBL:ORW75361.1,
RC ECO:0000313|Proteomes:UP000193024};
RA Tarcisio F., Conor M., Antonella G., Elisabetta G., Giulia F.S., Sara T.,
RA Anna F., Clotilde B., Roberto B., Veronica D.S., Fabio R., Monica P.,
RA Olivier J., Enrico T., Nicola S.;
RT "The new phylogeny of the genus Mycobacterium.";
RL Submitted (JAN-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ODR08474.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BC1_M4 {ECO:0000313|EMBL:ODR08474.1};
RA Capua I., De Benedictis P., Joannis T., Lombin L.H., Cattoli G.;
RL Submitted (SEP-2016) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Proteomes:UP000094224}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BC1_M4 {ECO:0000313|Proteomes:UP000094224};
RA Greninger A.L., Jerome K.R., Mcnair B., Wallis C., Fang F.;
RL Submitted (SEP-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=3-hydroxypropanoate + NADP(+) = 3-oxopropanoate + H(+) +
CC NADPH; Xref=Rhea:RHEA:26438, ChEBI:CHEBI:15378, ChEBI:CHEBI:16510,
CC ChEBI:CHEBI:33190, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349;
CC EC=1.1.1.298; Evidence={ECO:0000256|ARBA:ARBA00043756};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=L-allo-threonine + NADP(+) = aminoacetone + CO2 + NADPH;
CC Xref=Rhea:RHEA:43524, ChEBI:CHEBI:16526, ChEBI:CHEBI:57783,
CC ChEBI:CHEBI:58320, ChEBI:CHEBI:58349, ChEBI:CHEBI:58585;
CC EC=1.1.1.381; Evidence={ECO:0000256|ARBA:ARBA00043812};
CC -!- SIMILARITY: Belongs to the short-chain dehydrogenases/reductases (SDR)
CC family. {ECO:0000256|ARBA:ARBA00006484, ECO:0000256|RuleBase:RU000363}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ODR08474.1}.
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DR EMBL; MIHC01000008; ODR08474.1; -; Genomic_DNA.
DR EMBL; LQPT01000099; ORW75361.1; -; Genomic_DNA.
DR RefSeq; WP_069399516.1; NZ_MIHC01000008.1.
DR STRING; 243061.AWC25_14315; -.
DR OrthoDB; 9810734at2; -.
DR Proteomes; UP000094224; Unassembled WGS sequence.
DR Proteomes; UP000193024; Unassembled WGS sequence.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR020904; Sc_DH/Rdtase_CS.
DR InterPro; IPR002347; SDR_fam.
DR PANTHER; PTHR43086:SF3; NADP-DEPENDENT 3-HYDROXY ACID DEHYDROGENASE YDFG; 1.
DR PANTHER; PTHR43086; VERY-LONG-CHAIN 3-OXOOACYL-COA REDUCTASE; 1.
DR Pfam; PF00106; adh_short; 1.
DR PIRSF; PIRSF000126; 11-beta-HSD1; 1.
DR PRINTS; PR00081; GDHRDH.
DR PRINTS; PR00080; SDRFAMILY.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR PROSITE; PS00061; ADH_SHORT; 1.
PE 3: Inferred from homology;
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000094224}.
SQ SEQUENCE 267 AA; 28001 MW; 6882F89CD8FA8358 CRC64;
MSLPKPANQS TVVITGASSG IGAELARGLA RRGFPLLLVA RRRERLDELA GQLGEEFSVA
VEVLPLDLSD AKARAKLADR LRTESIAGLC NSAGFGTSGV FRELPLERES EEVTLNALAL
MELTHAALGG MVERGAGAVL NIASIAAFQP LPYMAVYSAT KAFVQTFSEA VHEELHGTGV
SVTALCPGPV PTEWAEIANA KRFSVPLAQV SPADVAEAAI DGMLTGKRTV VPGVVPKVVS
NGGRYTPRSL LLPAIRIGNR FRGGPSH
//
