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Database: UniProt
Entry: A0A1E3WBF6_9RHIZ
LinkDB: A0A1E3WBF6_9RHIZ
Original site: A0A1E3WBF6_9RHIZ 
ID   A0A1E3WBF6_9RHIZ        Unreviewed;       308 AA.
AC   A0A1E3WBF6;
DT   18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT   18-JAN-2017, sequence version 1.
DT   16-JAN-2019, entry version 9.
DE   RecName: Full=Homoserine dehydrogenase {ECO:0000256|RuleBase:RU000579};
DE            EC=1.1.1.3 {ECO:0000256|RuleBase:RU000579};
DE   Flags: Fragment;
GN   ORFNames=AUC71_11755 {ECO:0000313|EMBL:ODS03060.1};
OS   Methyloceanibacter marginalis.
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rhizobiales;
OC   Methyloceanibacter.
OX   NCBI_TaxID=1774971 {ECO:0000313|EMBL:ODS03060.1};
RN   [1] {ECO:0000313|EMBL:ODS03060.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=R-67177 {ECO:0000313|EMBL:ODS03060.1};
RX   PubMed=27501305;
RA   Vekeman B., Kerckhof F.M., Cremers G., de Vos P., Vandamme P.,
RA   Boon N., Op den Camp H.J., Heylen K.;
RT   "New Methyloceanibacter diversity from North Sea sediments includes
RT   methanotroph containing solely the soluble methane monooxygenase.";
RL   Environ. Microbiol. 0:0-0(2016).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=L-homoserine + NADP(+) = H(+) + L-aspartate 4-
CC         semialdehyde + NADPH; Xref=Rhea:RHEA:15761, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:57476, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349,
CC         ChEBI:CHEBI:537519; EC=1.1.1.3;
CC         Evidence={ECO:0000256|RuleBase:RU000579};
CC   -!- PATHWAY: Amino-acid biosynthesis; L-methionine biosynthesis via de
CC       novo pathway; L-homoserine from L-aspartate: step 3/3.
CC       {ECO:0000256|RuleBase:RU000579}.
CC   -!- PATHWAY: Amino-acid biosynthesis; L-threonine biosynthesis; L-
CC       threonine from L-aspartate: step 3/5.
CC       {ECO:0000256|RuleBase:RU000579}.
CC   -!- SIMILARITY: Belongs to the homoserine dehydrogenase family.
CC       {ECO:0000256|RuleBase:RU004171}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:ODS03060.1}.
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DR   EMBL; LPWD01000177; ODS03060.1; -; Genomic_DNA.
DR   EnsemblBacteria; ODS03060; ODS03060; AUC71_11755.
DR   UniPathway; UPA00050; UER00063.
DR   UniPathway; UPA00051; UER00465.
DR   GO; GO:0004412; F:homoserine dehydrogenase activity; IEA:UniProtKB-EC.
DR   GO; GO:0050661; F:NADP binding; IEA:InterPro.
DR   GO; GO:0009097; P:isoleucine biosynthetic process; IEA:UniProtKB-KW.
DR   GO; GO:0009086; P:methionine biosynthetic process; IEA:UniProtKB-KW.
DR   GO; GO:0009088; P:threonine biosynthetic process; IEA:UniProtKB-UniPathway.
DR   InterPro; IPR005106; Asp/hSer_DH_NAD-bd.
DR   InterPro; IPR001342; HDH_cat.
DR   InterPro; IPR019811; HDH_CS.
DR   InterPro; IPR022697; HDH_short.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   Pfam; PF00742; Homoserine_dh; 1.
DR   Pfam; PF03447; NAD_binding_3; 1.
DR   PIRSF; PIRSF036497; HDH_short; 1.
DR   SUPFAM; SSF51735; SSF51735; 1.
DR   PROSITE; PS01042; HOMOSER_DHGENASE; 1.
PE   3: Inferred from homology;
KW   Amino-acid biosynthesis {ECO:0000256|RuleBase:RU000579};
KW   Branched-chain amino acid biosynthesis
KW   {ECO:0000256|RuleBase:RU000579};
KW   Isoleucine biosynthesis {ECO:0000256|RuleBase:RU000579};
KW   Methionine biosynthesis {ECO:0000256|RuleBase:RU000579};
KW   NADP {ECO:0000256|PIRSR:PIRSR036497-2, ECO:0000256|RuleBase:RU000579};
KW   Oxidoreductase {ECO:0000256|RuleBase:RU000579};
KW   Threonine biosynthesis {ECO:0000256|RuleBase:RU000579}.
FT   DOMAIN       11    131       NAD_binding_3. {ECO:0000259|Pfam:
FT                                PF03447}.
FT   DOMAIN      139    307       Homoserine_dh. {ECO:0000259|Pfam:
FT                                PF00742}.
FT   NP_BIND      11     16       NADP. {ECO:0000256|PIRSR:PIRSR036497-2}.
FT   ACT_SITE    207    207       Proton donor. {ECO:0000256|PIRSR:
FT                                PIRSR036497-1}.
FT   BINDING     107    107       NADP. {ECO:0000256|PIRSR:PIRSR036497-2}.
FT   BINDING     192    192       Substrate. {ECO:0000256|PIRSR:
FT                                PIRSR036497-2}.
FT   NON_TER     308    308       {ECO:0000313|EMBL:ODS03060.1}.
SQ   SEQUENCE   308 AA;  32233 MW;  1D205684B59F70E2 CRC64;
     MADGLKLGLA GIGTVGGGLL RLIEAHAGAL AERAGRPIEV IAVSARNKRK KRDVDLSGVR
     FVQDPIKLAT DPEIDVFVEL IGGEEGIAKE AVETALRAGK HVVTANKALL AHHGPNLAAL
     AEKHGVALNF EGAVAGGIPV VKVIREGLQG NDITRVYGIL NGTCNYILTL MEREGRSFAD
     VLKEAQEQGY AEADPTFDVG GFDTAHKLAL LTSLAFGTRT KFDAVYVEGI ETITPADIEA
     ADDLGYRIKL LGVALRTDSG IEQRVHPTMV PKDTAIANVD GVSNCVAIDG DFVGDVMLIG
     PGAGGGPR
//
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