ID A0A1E4JLS3_9PROT Unreviewed; 763 AA.
AC A0A1E4JLS3;
DT 18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT 18-JAN-2017, sequence version 1.
DT 13-SEP-2023, entry version 15.
DE SubName: Full=DNA internalization-related competence protein ComEC/Rec2 {ECO:0000313|EMBL:ODU26819.1};
GN ORFNames=ABS93_03690 {ECO:0000313|EMBL:ODU26819.1};
OS Thiobacillus sp. SCN 62-729.
OC Bacteria; Pseudomonadota; Betaproteobacteria; Nitrosomonadales;
OC Thiobacillaceae; Thiobacillus.
OX NCBI_TaxID=1660148 {ECO:0000313|EMBL:ODU26819.1, ECO:0000313|Proteomes:UP000094151};
RN [1] {ECO:0000313|EMBL:ODU26819.1, ECO:0000313|Proteomes:UP000094151}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=26031303; DOI=10.1111/1462-2920.12936;
RA Kantor R.S., van Zyl A.W., van Hille R.P., Thomas B.C., Harrison S.T.,
RA Banfield J.F.;
RT "Bioreactor microbial ecosystems for thiocyanate and cyanide degradation
RT unravelled with genome-resolved metagenomics.";
RL Environ. Microbiol. 17:4929-4941(2015).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ODU26819.1}.
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DR EMBL; MEFL01000062; ODU26819.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1E4JLS3; -.
DR Proteomes; UP000094151; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0030420; P:establishment of competence for transformation; IEA:InterPro.
DR CDD; cd07731; ComA-like_MBL-fold; 1.
DR Gene3D; 3.60.15.10; Ribonuclease Z/Hydroxyacylglutathione hydrolase-like; 1.
DR InterPro; IPR035681; ComA-like_MBL.
DR InterPro; IPR004477; ComEC_N.
DR InterPro; IPR004797; Competence_ComEC/Rec2.
DR InterPro; IPR025405; DUF4131.
DR InterPro; IPR001279; Metallo-B-lactamas.
DR InterPro; IPR036866; RibonucZ/Hydroxyglut_hydro.
DR NCBIfam; TIGR00360; ComEC_N-term; 1.
DR NCBIfam; TIGR00361; ComEC_Rec2; 1.
DR PANTHER; PTHR30619; DNA INTERNALIZATION/COMPETENCE PROTEIN COMEC/REC2; 1.
DR PANTHER; PTHR30619:SF1; RECOMBINATION PROTEIN 2; 1.
DR Pfam; PF03772; Competence; 1.
DR Pfam; PF13567; DUF4131; 1.
DR Pfam; PF00753; Lactamase_B; 1.
DR SMART; SM00849; Lactamase_B; 1.
DR SUPFAM; SSF56281; Metallo-hydrolase/oxidoreductase; 1.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 50..69
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 213..232
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 252..276
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 288..306
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 341..371
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 383..405
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 417..437
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 443..466
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 510..703
FT /note="Metallo-beta-lactamase"
FT /evidence="ECO:0000259|SMART:SM00849"
SQ SEQUENCE 763 AA; 83779 MW; 8369FA26D63989BE CRC64;
MRITLIAFCF GVWLLQQQAA LPSARWLWLL PLLSAALWLP RFSREVPETL RRLAVVLLGV
ALGFAWAAWR ADLRLADRLP EHWQGVDLAV VGVVNDLPQA DTRGERFVLD VERTLTPHGP
VLHRIQLARY WPREGARNPT VKAGERWQFT VRLKRPYGTH NPHGFDLEAW MLERDIAASG
YVRENPSPRR LDAQAATPAA WIAATRAAIR ERIAATLGDA PYAGVIAALV VGDQRSIPYD
QWRAFTRTGV NHLLSISGLH VTMIAALAGW AVAFGWRRWP RAAERLPARQ AGLLAAVLAA
YAYALLAGFQ VPAQRTLFML GVLALAFWGR REPRPFSALT WALFAVLVID PWAVLSAGFW
LSFGAMAAIL WATFGRVGQA DKLRAWVTVQ GAVTLALAPA LLLLFQQVSL ISPLANVIAI
PVVSWLVTPL ALLGVVVPPL WHVAVWLMAW LGQGLIWASE LPWAVVSRPV PEGGALLLAV
TGTLWLPLIF PLRTSIAPDT FQADVIDVGQ GTAILIRTAE HALLYDTGPA FAGSDAGERI
VVPYLRTLGI GKLSGVIVSH DDNDHSGGLQ SVLRDIPTGW LLHGLPTASP LLTAAPSPRH
CHRGQHWLWD GVRFDILNPP VAAYTESGRR DNDYSCVLKV SWGGQSLLIT GDAERRGELE
LLESSTDMAA TVLVAGHHGS RTSSLAEFVE QVHPRYGVFT VGYRNRFGHP HPQVVARFRA
LDSTILRSDS GGRISLTFGE AGVVASEYRP SHRRYWHTAL FDE
//
